1st Edition

Computational Protein-Protein Interactions

Edited By Ruth Nussinov, Gideon Schreiber Copyright 2009
344 Pages 74 B/W Illustrations
by CRC Press

336 Pages 74 B/W Illustrations
by CRC Press

344 Pages
by CRC Press

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current research directions, Computational Protein-Protein... Read more

Basic Principles of Protein–Protein Interaction, J. Janin
Low-Resolution Recognition Factors Determine Major Characteristics of the Energy Landscape in Protein–Protein Interaction, I.A. Vakser
The Molecular Architecture of Protein–Protein Binding Sites, E.J. Sundberg
Mapping Protein Function by Combinatorial Mutagenesis, G. Pál and S.S. Sidhu
The Association of Protein–Protein Complexes, G. Schreiber
Computational Simulations of Protein–Protein and Protein–Nucleic Acid Association, G.V. Pachov, R.R. Gabdoulline, and R.C. Wade
Computational Design of Protein–Protein Interactions, J.M. Shifman
Protein–Protein Docking, H. Hwang, B. Pierce, and Z. Weng
Prediction of Protein Interaction Sites, Y. Ofran
Predicting Molecular Interactions in Structural Proteomics, I. Kufareva and R. Abagyan
Rearrangements and Expansion of the Domain Content in Proteins Frequently Increase the Protein Connectivity in the Protein–Protein Interaction Network, I. Cohen-Gihon, R. Sharan, and R. Nussinov
Intrinsically Disordered Proteins and Their Recognition Functions, V.N. Uversky, M. Fuxreiter, C.J. Oldfield, A.K. Dunker, and P. Tompa
Identification of Druggable Hot Spots on Proteins and in Protein–Protein Interfaces, D. Beglov, R. Brenke, G.-Y. Chuang, D. Hall, M. Landon, C.H. Ngan, Y. Shen, S. Thiel, B. Zerbe, D. Kozakov, and S. Vajda
Designing Protein–Protein Interaction Inhibitors, M. Montes
Index

Biography

Ruth Nussinov, Gideon Schreiber