1st Edition

Concise Clinical Immunology for Healthcare Professionals





ISBN 9780415298308
Published March 9, 2006 by Routledge
454 Pages

USD $68.95

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Book Description

This up-to-date immunology textbook provides a clear and simple introduction to clinical and laboratory immunology for health professionals in training or in practice. It covers:

  • essential basic immunology
  • clinical immunology
  • laboratory investigations of immunological disorders
  • treatments used in immunological disorders.

Focusing on clinical problems seen in practice and including self-assessment questions and case histories to aid learning and understanding, this is an invaluable resource for all medical students, nurses, nutritionists, pharmacists and physiotherapists.

Table of Contents

Part 1: Basic Immunology  1. Introduction  2. Overview of Defence Mechanisms  3. Cells and Organs of the Immune System  4. Innate Immune Responses I  5. Innate Immune responses II – The Complement System  6. Innate Immune Responses III - Other Soluble Factors  7. Inflammation  8. What the Immune System Recognises  9. Human Leucocyte Antigen Modules  10. Antigen Presentation  11. How Does the Immune System See Antigen?  12. Lymphocyte Maturation  13. Immunoglobin structure  14. B Cell Activation  15. Immunoglobin Function  16. T Cell Receptor and Immune Repertoire  17. Helper T Cell Activation  18. Cytotoxic T Cells  19. The Mucosal Immune System  20. Initiation of the Immune Response  21. Maintenance of the Immune Response  22. Control of the Immune Response  23. Ontogeny of the Immune Response  24. Immune Responses to Infection  25. How Organisms Evade the Immune System  26. Consequences of Immune Response  27. Host Defence Against Tumours  28. Autoimmunity  29. Hypersensitivity  30. Atopy and Allergic Inflammation Self Assessment  Part 2: Clinical Immunology  1. Clinical Manifestations of Atopy  2. Asthma  3. Urticaria and Angioedema  4. Food Allergy  5. Anaphylaxis  6. Other Types of Hypersensitivity Reactions  7. Immunodeficiency  8. Defects in Antibody - Mediated Immunity  9. Defects in T Cell-mediated Immunity  10. Neutrophil Disorders  11. Complement Deficiency  12. Defective Splenic Function  13. HIV  14. Autoimmunity  15. Autoimmune Endocrinopathies  16. Immune-mediated Haematological Conditions  17. Autoimmune Liver Disease  18. Immune-mediated Gastrointestinal Disorders  19. Immune-mediated Neurological Disease  20. Immune-mediated Skin Disease  21. Immune-mediated Renal Disease  22. Rheumatiod Disease and Spondylarthopathies  23. Connective Tissue Diseases  24. Vasculitides  25. Hypersensitivity Induced by Pathogens  26. Transplantation  27. Haemopoietic Stem Cell Transplantation  28. Solid Organ Transplantation  29. Lymphoid Malignances  30. Leukaemia and Lymphoma  31. Plasma Cell Diseases Self-Assessment  Part 3: Immunotechniques and Diagnostic Tests Used in Clinical Immunology  1. Laboratory Tests in Clinical Immunology  2. Antibodies are Essential Tools in the Clinical Immunology Laboratory  3. Detection of Antibodies and Antigen  4. Autoantibody Profiles in Connective Tissue Diseases and Rheumatoid Diseases  5. Autoantibodies Associated with Vasculitic Syndromes and Renal Diseases  6. Autoantibodies Associated with Liver and Gastrointestinal Diseases  7. Autoantibodies Associated with Endocrine Diseases and Pernicious Anaemia  8. Other Organ-specific Autoimmunity  9. Measurement of the Acute Phase Response  10. Complement  11. Immunodeficiency  12. Abnormal Immunoglobulins  13. Angioedema: C1-Inhibitor Disorders  14. Allergy and Hypersensitivity  15. Transplantation  16. Immunophenotyping Leukaemias and Lymphomas  17. Direct Immunofluorescence Self Assessment  Part 4: Treatment of Immunological Disorders  1. Principles of Immunosuppression  2. Corticosteroids  3. Immunosuppression (I)  4. Immunosuppression (II)  5. Therapeutic Antibody Production  6. Targeted Cell Depletion  7. Other Antibody Therapies  8. Immunoglobulin Replacement Therapy  9. High Dose Immunoglobin Therapy  10. Cytokines  11. Vaccination and Passive Immunisation  12. Plasmapheresis and Plasma Exchange  13. Management of Acute Allergic Reactions Self Assessment Clinical Immunology: Future Prospects

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Author(s)

Biography

Mary Keogan is Consultant Clinical Immunologist at Beaumont and Mater Misericordiae Hospitals, Dublin and Senior Lecturer in Pathology, Royal College of Surgeons in Ireland. Eleanor Wallace is Medical Scientist in the Department of Immunology, Beaumont Hospital, Dublin. Paula O’Leary is Senior Tutor in the Department of Medicine, Cork University Hospital, Ireland.