This book is a collection of works that canvass many of the recent developments in various areas of connective tissue research. It focuses on the structure of the components, molecular organization and pathology of the extracellular matrix.
Part I: Structure and Biology of the Components of the Extracellular Matrix 1. The Collagen Family of Proteins 2. Elastin: Structure and Biology 3. The Microfibrillar Component of the Elastic Fibers: Morphology and Biochemistry 4. Advances in the Biochemistry of Proteoglycans Part II: Molecular Organization of the Extracellular Matrix 5. Diseases of the Extracellular Matrix: Structural Alterations of Collagen Fibrils in Skin 6. The Molecular Organization of Basement Membrane 7. Vascular Connective Tissue: Normal Biology and Derangement in Human Diseases 8. Cell-Matrix Interactions: Biochemistry of Close and Tight-Focal Adhesive Contacts of Fibroblasts to Extracellular Matrices 9. Matrix Interactions of Cell Surface Proteoglycans 10. Intracellular Degradation as a Modulator of Collagen Production Part III: Pathology of the Extracellular Matrix 11. Disorders Associated with Collagen Biosynthesis: Dermatological Diseases as Prototypes for Collagen Abnormalities 12. Posttranslational Modifications of Collagen and Their Alterations in Heritable Diseases 13. Genetic Diseases of Collagen in Animals 14. The Molecular Pathology of Pulmonary Fibrosis 15. Fibrotic Skin Diseases: Keloids as a Model to Study the Mechanisms of Collagen Deposition in Tissues 16. Pharmacological and Environmental Modulation of Wound Healing 17. Molecular Mechanisms of Glucocorticoid Action on Connective Tissue Metabolism 18. Pathology of the Elastic Fibers 19. Pulmonary Emphysema: From Animal Models to Human Diseases 20. Fibronectin and Disease Processes 21. Vascular and Cutaneous Complications of Diabetes Mellitus: The Role of Nonenzymatic Glucosylation of Collagens 22. Diseases of Glycosaminoglycan and Proteoglycan Metabolism 23. The Role of Connective Tissue Degrading Enzymes in Human Pathology