Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology, 1st Edition (e-Book) book cover

Connexin Cell Communication Channels

Roles in the Immune System and Immunopathology, 1st Edition

Edited by Ernesto Oviedo-Orta, Brenda R. Kwak, William Howard Evans

CRC Press

380 pages

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pub: 2017-11-15
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Description

Plasma membrane-associated channels known as gap junctions, along with their protein building blocks-connexins-have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communicati

Table of Contents

Immunology and Cell Biology. Communication in the Immune System by Connexin Channels. Gap Junctions and Connexins in the Hematopoietic-Immune System: Structural Considerations. Approaches for Studying the Role(s) of Gap Junctions in the Immune System. Gap Junctions in Antigen-Presenting Cells. Connect the Immune System: Roles of Gap Junctions in Antigen Presentation and T Cell Activation. Gap Junctions and Connexins in the Immune Defense against Tumors. Inflammation and Inflammatory Diseases. Connexins in Atherosclerosis. Connexins in Lung Function and Inflammation. Effect of Oxidative Stress on Connexins in the Vasculature. Regulation of Gap Junctions and Cellular Coupling within the Microvasculature in Response to Acute Inflammation. Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation. A Role for Connexins in Inflammatory Disorders of the Epidermis. Connexin-Based Therapeutical Approaches in Inflammatory Diseases. Translating Basic Research on Cx43 Gap Junctions into Therapies for Reducing Scarring and Cardiac Arrhythmia. Connexin-Based Therapeutic Approaches to Inflammation in the Central Nervous System. Enhancing Epithelial Tissue Repair and Reducing Inflammation by Targeting Connexins. Index.

About the Editors

Ernesto Oviedo-Orta received his MD from the Havana Medical School in Cuba where he also specialized in clinical immunology. During his postgraduate specialist training, he engaged in vaccine research related to diverse infectious agents and diseases, including measles and hepatitis C. Dr. Oviedo-Orta's Ph.D. research work in Cardiff, UK, focused on the role of gap junction intercellular communication in the immune system. His work continued in this area both in Bristol and Guildford, UK, but with special attention to immune regulation. Dr. Oviedo-Orta is currently a Clinical Sciences Expert at Novartis Vaccines & Diagnostics, Siena, Italy, where he is a medical and scientific advisor supporting new and ongoing projects in vaccine research and clinical development.

Brenda R. Kwak studied at the University of Amsterdam, the Netherlands, where she also obtained her PhD. Dr. Kwak carried out her PhD research work focusing on the regulation of cardiac gap junction channels using a dual patch-clamp approach. She then continued her work for several years as a postdoctoral fellow at the University of Utrecht, the Netherlands. After moving to the University of Geneva, she focused on the vascular system, first in the endothelium at the Department of Morphology, and later on the regulation of major histocompatibility complex class II (MHC-II) in the context of atherosclerosis at the Department of Internal Medicine-Cardiology. On receiving a professorship from the Swiss National Science Foundation in 2003, she established an independent research group in the same department to dissect the role of Cxs in atherosclerosis. She is now associate professor to both the Department of Pathology and Immunology and to the Department of Internal Medicine-Cardiology at the University of Geneva and focuses more broadly on the role of Cxs in cardiovascular physiology and pathology, work that still includes atherosclerotic disease but

Subject Categories

BISAC Subject Codes/Headings:
MED014000
MEDICAL / Clinical Medicine
MED044000
MEDICAL / Immunology
SCI017000
SCIENCE / Life Sciences / Cytology