1st Edition
Control of Breathing during Sleep From Bench to Bedside
This book describes control of ventilation during sleep in both health and disease states. The topics are presented in a fashion that can be easily comprehended with many figures to illustrate complex concepts. Thus, a wide range of topics, starting from the site of normal respiratory rhythm generation to chemoreceptor control of sleep apnea, description of the apneic threshold, pathophysiology of upper airway closure, novel techniques to measure control of breathing, effect of cerebral blood flow on breathing, effect of opioids on ventilation, effect of heart failure on ventilation, genetic aspects of breathing disorders, age and gender differences, and various therapies are discussed.
Key Features
• Helps to bridge the gap between straight forward physiology and clinical practice through a range of topics and use of case vignettes
• Explores various aspects of clinical management and control which is beneficial to sleep clinicians, respiratory physiologists, intensivists, trainees, and researchers.
• Distills complex concepts into understandable language and figures, providing helping resource to the clinicians, that transforms a dry topic vis a viz control of ventilation into an exciting understandable ‘clinician’ language.
Foreword
Preface
About the Editors
List of Contributors
SECTION I. ANATOMY, DEVELOPMENT, AGING, AND MECHANISMS OF CONTROL OF VENTILATION
1. Anatomy of the Respiratory Neural Network
Christopher A. Del Negro and Christopher G. Wilson
2. Chemoreception: Pathways, Plasticity, and Pathophysiology
Barbara J. Morgan and Jerome A. Dempsey
3. Developmental Changes in the Respiratory System of the Neonate-Child
Ahuva Brown, Liran Tamir Hostovsky, and Estelle B. Gauda
4. Control of Breathing in Older Adults
Susmita Chowdhuri
5. Breathing Control in Exercise
Philippe Haouzi
6. Control of the Upper Airway during Sleep
Leszek Kubin
SECTION II. PATHOPHYSIOLOGY OF SLEEP-DISORDERED BREATHING
7. Pathophysiology of Sleep-Disordered Breathing in Children and Neonates
Sofia Konstantinopoulou and Ignacio E. Tapia
8. Pathogenesis of Sleep-Disordered Breathing in Adults: Overview
Thomas M Tolbert, Indu Ayappa, and David M Rapoport
9. Risk and Causality by Genetics, Gender, and Age
Moshe Prero, Nardine Zakhary, Sally Ibrahim, and Kingman P. Strohl
10. The Influence of Cerebral Blood Flow and Cerebrovascular Responsiveness on Ventilatory Control
Jay M. J. R. Carr, Gustavo Vizcardo-Galindo, and Philip N. Ainslie
11. Central Apnea: Propensity and Plasticity
M.S. Badr
SECTION III. SLEEP-DISORDERED BREATHING IN DIFFERENT CONDITIONS AND DISEASE STATES
12. Sleep-Disordered Breathing due to Heart Failure
S. Javaheri and R. Germany
13. Breathing at Altitude
David Patz
14. Sleep-Disordered Breathing Associated with Chronic Lung Diseases
Bernie Y Sunwoo, Ana Sanchez-Azofra, and Atul Malhotra
15. Obesity Hypoventilation Syndrome
Amanda Piper
SECTION IV. PATHOPHYSIOLOGY-DIRECTED THERAPIES FOR SLEEP-DISORDERED BREATHING
16. Effect of Positive Airway Pressure on Ventilatory Control and Sleep-Disordered Breathing
James A Rowley
17. Mild Intermittent Hypoxia and Supplemental Oxygen: Potential Therapeutic Interventions to Treat Breathing Instability
Sreenavya Gandikota and Jason H. Mateika
18. Pharmacological Management of Sleep-Disordered Breathing
Thomas J. Altree, Peter G. Catcheside, Sutapa Mukherjee, and Danny J. Eckert
19. Neural Mechanisms Regulating Opioid-Induced Respiratory Depression and Therapeutic Strategies to Alleviate the Respiratory Side-Effects of Opioid Drugs
Jean-Philippe Rousseau and Gaspard Montandon
20. Pharmacologic Intervention Studies to Mitigate Breathing Instability – Animal Studies
Carla Freire, Lenise J. Kim, and Vsevolod Y. Polotsky
Index
Biography
Dr. Susmita Chowdhuri, M.D., M.S. is a Professor of Internal Medicine at Wayne State University School of Medicine and a Staff Physician and the Section Chief of Sleep Medicine at the John D. Dingell VA Medical Center in Detroit, Michigan.
Dr. M. Safwan Badr, M.D., M.B.A. is a Professor and Chair of Internal Medicine at Wayne State University School of Medicine and a Staff Physician at the John D. Dingell VA Medical Center.
Dr. James A Rowley is a Professor of Medicine and Division Chief of Pulmonary/Critical Care and Sleep mMdicine at Wayne State University School of Medicine in Detroit, Michigan.
This book provides an excellent overview of pathophysiology and treatment options associated with management of one of the core problems of pulmonary medicine. Reference lists allow effective secondary literature review. Illustrations clearly support presentations made. This is a worthy tool for intensivists and pulmonary providers at all levels of sophistication.
- David James Dries, MSE, MD, Regions Hospital
