Controlled Drug Delivery Systems
This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs.
In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.
Foreword - David Williams; Preface – Emmanuel C Opara; Chapter 1: Introduction – Approaches to controlled drug delivery - Antonios Mikos; Chapter 2: Chemical modifications of alginate for controlled drug delivery and regenerative medicine - Mark E. Welker; Chapter 3: Hydrogel systems for delivery and release of cell-secreted and synthetic therapeutic products – Aleks Skardal; Chapter 4: The effect of glutathione incorporated as chain transfer agent in thermo-sensitive hydrogels for controlled release of therapeutic proteins – V Perez-Luna; Chapter 5: Controlled vaccine delivery – Kevin McHugh; Chapter 6: Controlled release of hormone by pellet implants – Sivanandane Sittadjody; Chapter 7: Delivery of ovarian hormones for bone health - Justin Saul; Chapter 8: Controlled delivery models of bioactive factors for the maturation of engineered tissues -Ashkan Shafiee & Atala; Chapter 9: Controlled delivery of angiogenic proteins – Eric M Brey; Chapter 10: Controlled therapeutic delivery in wound healing – Sean Murphy; Chapter 11: Leveraging plasma insulin estimates and wearable technologies to develop an automated insulin delivery system in Type 1 diabetes – A Cinar; Chapter 12: New developments in oral insulin delivery – Emmanuel C Opara; Chapter 13: Insulin delivery by a bioartficial pancreas– Will Kendall; Chapter 14: Transdermal drug delivery - Brahmeshwar Mishra; Chapter 15: Mucoadhesive chitosan-based nanoparticles for oral drug delivery - Shirui Mao; Chapter 16: Liposome-based delivery of therapeutic agents –Eneida de Paula; Chapter 17: Targeted intestinal delivery of probiotics – Emmanuel C. Opara