1st Edition

Copper Amine Oxidases Structures, Catalytic Mechanisms and Role in Pathophysiology

Edited By Giovanni Floris, Bruno Mondovi Copyright 2009
    374 Pages 13 Color & 50 B/W Illustrations
    by CRC Press

    374 Pages 13 Color & 50 B/W Illustrations
    by CRC Press

    Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences of between AOs from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.

    History, F. Buffoni

    Nomenclature and Potential Functions of Copper Amine Oxidases, S. Boyce, K. F. Tipton, M. I. O’Sullivan, G. P. Davey, M. Motherway Gildea, A. G. McDonald, A. Olivieri, and J. O’Sullivan

    Cofactors of Amine Oxidases: Copper Ion and Its Substitution and the 2, 4, 5-Trihydroxylphenylalanine Quinone, S. Suzuki, T. Okajima, K. Tanizawa, and M. Mure

    Copper Amine Oxidases from Plants, R. Medda, A. Bellelli, P. Pec, R. Federico, A.Cona, and G. Floris

    Soluble Copper Amine Oxidases from Mammals, P. Pietrangeli, L. Morpurgo, B. Mondovi, M. L. Di Paolo, and A. Rigo

    Membrane-Bound Copper Amine Oxidases, A. Holt

    Copper Amine Oxidase Genes, I. Frebort and H. G. Schwelberger

    Mechanism of TPQ Biogenesis in Prokaryotic Copper Amine Oxidase, T. Okajima and K.Tanizawa

    Copper Amine Oxidase Crystal Structures, J. Mitchell Guss, G. Zanotti, and T. A. Salminen

    Plasma Amine Oxidases in Various Clinical Conditions and in Apoptosis, F. Boomsma, A. H. van den Meiracker, and A. Toninello

    Copper Amine Oxidases in Intestine Diseases, W. Agnieszka Fogel, E. Toporowska-Kowalska, and A. Stasiak

    Copper Amine Oxidases in Adipose Tissue-Related Disorders, C. Carpene

    Copper Amine Oxidases in Adhesion Molecules in Renal Pathology and in Alzheimer’s Disease and VAP-1 in Leukocyte Migration, P. Boor, M. Unzeta, M. Salmi, and S. Jalkanen

    Inhibitors of Copper Amine Oxidases: Past, Present, and Future, M. Šebela and L. M. Sayre

    Pharmacological Applications of Copper Amine Oxidases, E. Masini and L. Raimondi

    Copper Amine Oxidases as Antioxidant and Cardioprotective Agents, M. Alexandru Mateescu and R. Nadeau

    Biotechnological Aspects of Copper Amine Oxidases, R. Stevanato

    Concluding Remarks, D. M. Dooley



    Giovanni Floris, Bruno Mondovi