Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology, 1st Edition (Paperback) book cover

Copper Amine Oxidases

Structures, Catalytic Mechanisms and Role in Pathophysiology, 1st Edition

Edited by Giovanni Floris, Bruno Mondovi

CRC Press

374 pages | 13 Color Illus. | 50 B/W Illus.

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Description

Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences of between AOs from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.

Table of Contents

History, F. Buffoni

Nomenclature and Potential Functions of Copper Amine Oxidases, S. Boyce, K. F. Tipton, M. I. O’Sullivan, G. P. Davey, M. Motherway Gildea, A. G. McDonald, A. Olivieri, and J. O’Sullivan

Cofactors of Amine Oxidases: Copper Ion and Its Substitution and the 2, 4, 5-Trihydroxylphenylalanine Quinone, S. Suzuki, T. Okajima, K. Tanizawa, and M. Mure

Copper Amine Oxidases from Plants, R. Medda, A. Bellelli, P. Pec, R. Federico, A.Cona, and G. Floris

Soluble Copper Amine Oxidases from Mammals, P. Pietrangeli, L. Morpurgo, B. Mondovi, M. L. Di Paolo, and A. Rigo

Membrane-Bound Copper Amine Oxidases, A. Holt

Copper Amine Oxidase Genes, I. Frebort and H. G. Schwelberger

Mechanism of TPQ Biogenesis in Prokaryotic Copper Amine Oxidase, T. Okajima and K.Tanizawa

Copper Amine Oxidase Crystal Structures, J. Mitchell Guss, G. Zanotti, and T. A. Salminen

Plasma Amine Oxidases in Various Clinical Conditions and in Apoptosis, F. Boomsma, A. H. van den Meiracker, and A. Toninello

Copper Amine Oxidases in Intestine Diseases, W. Agnieszka Fogel, E. Toporowska-Kowalska, and A. Stasiak

Copper Amine Oxidases in Adipose Tissue-Related Disorders, C. Carpene

Copper Amine Oxidases in Adhesion Molecules in Renal Pathology and in Alzheimer’s Disease and VAP-1 in Leukocyte Migration, P. Boor, M. Unzeta, M. Salmi, and S. Jalkanen

Inhibitors of Copper Amine Oxidases: Past, Present, and Future, M. Šebela and L. M. Sayre

Pharmacological Applications of Copper Amine Oxidases, E. Masini and L. Raimondi

Copper Amine Oxidases as Antioxidant and Cardioprotective Agents, M. Alexandru Mateescu and R. Nadeau

Biotechnological Aspects of Copper Amine Oxidases, R. Stevanato

Concluding Remarks, D. M. Dooley

References

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED071000
MEDICAL / Pharmacology
SCI017000
SCIENCE / Life Sciences / Cytology