This book provides an insight into the rapidly growing field of cortical plasticity. It brings together diverse experimental approaches to the study of activity-dependent changes in neuronal connections, as exemplified by long-term potentiation (LTP) and long-term depression (LTD).
1. Introduction and overview 2. The role of amino acid receptors in synaptic plasticity 3. Second messengers in LTP and LTD 4. The locus of expression of NMDA receptor-dependent LTP in the hippocampus 5. Post-translational mechanisms which could underlie the postsynaptic expression of LTP and LTD 6. Postsynaptic gene expression and long-term potentiation in the hippocampus 7. Neuromodulators of synaptic strength 8. Epileptogenesis 9. Bidirectional plasticity of cortical synapses 10. Synaptic plasticity in the cerebellum 11. Roles of LTP and LTD in neuronal network operations in the brain