1st Edition

Cryopreservation
Applications in Pharmaceuticals and Biotechnology




ISBN 9780367399399
Published September 25, 2019 by CRC Press
504 Pages

USD $74.95

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Book Description

This book covers the principles of cryopreservation as they relate the preservation of viable cells and cell materials being developed for biopharmaceutical applications. Topics include: the principles of freezing and thawing cells, physiochemical phenomena, process and system design options, method selection considerations, preservation procedures, cryoprotectant additives, freeze-drying human live virus vaccines, and transport system selection criteria. Contributions from well-known experts such as Steven S. Lee, Thomas C. Pringle, William H. Siegel, Richard Wisniewski, and Fangdong Yin make this the single most important study available.

Table of Contents

Contents include: Principles & Scale-up: Cryopreservation for Cells, Microorganisms, Protein Solutions, Biopharmaceutical Formulations, & Biological Products. Large-Scale Cryopreservation: Process Development for Freezing & Thawing of Large Volumes of Cell Suspensions, Protein Solutions & Biological Products. Methods: Long-Term Preservation of Mammalian Cells & Microorganisms. Cryopreservation of Mammalian Cell Culture Materials. Freeze-Drying of Human Live Virus Vaccines. The Design & Use of Thermal Transport Containers.

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Editor(s)

Biography

Kenneth E. Avis , Carmen M. Wagner