This volume details the principles and instrumentation of gas chromatography-mass spectrometry (CG-MS), and outlines industrial, environmental, pharmaceutical, clinical, toxicological, forensic and food-related applications, revealing findings from the laboratories of 40 contributing scientists around the world using GC-MS in practice. It describes upstream and downstream applications of GC-MS in the petroleum industry and identifies chlorinated compounds in the environment with quadrupole ion-trap technology and high-resolution sector instruments.
Part 1 Principles and instrumentation of GC-MS: principles and instrumentation of GC-MS; principles and applications of surface ionization in GC-MS. Part 2 Industrial and environmental applications: GC-MS in the petroleum industry; analysis of dioxins and PCBs by quadrupole ion-trap GC-MS; GC-MS analysis of chlorinated organic compounds; principles, instrumentation and application of SPE-GC-MS and LC-GC-MS; GC-MS in occupational and environmental health risk assesment with some applications related to environmental and biological monitoring of 1-nitopyrene; application of SPME-GC-MS in quantitative bioanalysis. Part 3 Pharmaceutical and clinical applications: GC-MS of drugs in biological fluids after automated sample pre-treatment; GC-MS analysis of anaesthetics and metabolites using multidimensional detection strategies; GC-MS in clinical stable isotope studies - possibilities and limitations; clinical steroid analysis by GC-MS; GC-MS for selective screening for inborn errors of metabolism. Part 4 Toxicological and forensic applications: applications of GC-MS in clinical and forensic toxicology and doping control; detection of drugs of abuse by GC-MS; GC-MS analysis of explosives. Part 5 Food-related applications: GC-MS analysis of flavours and fragrances; GC-MS analysis for residue analysis - some basic concepts; applications of GC-MS in residue analysis of veterinary hormonal substances and endocrine disruptors; identification of terpenes by GC-MS.