Cyclic Nucleotide Phosphodiesterases in Health and Disease: 1st Edition (Hardback) book cover

Cyclic Nucleotide Phosphodiesterases in Health and Disease

1st Edition

Edited by Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay

CRC Press

728 pages | 250 B/W Illus.

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Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.

Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE families including the molecular characteristics, structure, function, and traits unique to each. Characteristics of PDEs from lower organisms are also the subject of other chapters since they provide key insights into PDE functions and are also pharmacological targets for treatment of a variety of diseases in humans and domestic animals. Chapters on the current biomedical and therapeutic research on PDEs include studies on gene-targeted knockout strategies and compartmentation in cyclic nucleotide signaling. By unraveling the unique cellular roles for different PDEs, scientists are beginning to open the door to the therapeutic use of PDE inhibitors for the treatment of a number of pathological conditions including asthma and inflammation, pulmonary hypertension, erectile dysfunction, and stroke.

By collating current information into a coherent and coordinated perspective, Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an invaluable reference for industry and clinical scientists and points toward future directions of research and therapeutic advancements in developing selective inhibitors for these various enzymes.

Table of Contents

Cyclic Nucleotide Phosphodiesterase Superfamily, J. A. Beavo, M. D. Houslay, and S. H. Francis

Phosphodiesterase Isoforms—An Annotated List, G. B. Bolger

Section A

Specific Phosphodiesterase Families—Regulation, Molecular and Biochemical Characteristics

Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases, A. T. Bender

PDE2 Structure and Functions, S. E. Martinez

Phosphodiesterase 3B: An Important Regulator of Energy Homeostasis, E. Degerman and V. Manganiello

Cellular Functions of PDE4 Enzymes, G. B. Bolger, M. Conti, and M. D. Houslay

Phosphodiesterase 5: Molecular Characteristics Relating to Structure, Function, and Regulation, S. H. Francis, R. Zoraghi, J. Kotera, H. Ke, E. P. Bessay, M. A. Blount, and J. D. Corbin

Photoreceptor Phosphodiesterase (PDE6): A G-Protein-Activated PDE Regulating Visual Excitation in Rod and Cone Photoreceptor Cells, R. H. Cote

PDE7, T. Michaeli


PDE 8 , V. Vasta

PDE9, J. Kotera and K. Omori

PDE10A: A Striatum Enriched, Dual-Substrate Phosphodiesterase, C. A. Strick, C. J. Schmidt, and F. S. Menniti

PDE11, K. Omori and J. Kotera

Section B

Nonmammalian Phosphodiesterases

Protozoal Phosphodiesterases, L.Wentzinger and T. Seebeck

Studies of Phosphodiesterase Function Using Fruit Fly Genomics and Transgenics, S. A. Davies and J. P. Day

Section C

Phosphodiesterases Functional Significance: Gene-Targeted Knockout Strategies

Insights into the Physiological Functions of PDE4 from Knockout Mice, S. L. C. Jin, W. Richter, and M. Conti

Regulation of cAMP Level by PDE3B—Physiological Implications in Energy Balance and Insulin Secretion, A. Z. Zhao and L. Stenson Holst

Section D

Compartmentation in Cyclic Nucleotide Signaling

Heart Failure, Fibrosis, and Cyclic Nucleotide Metabolism in Cardiac Fibroblasts, S. A. Epperson and L. L. Brunton

Role of A-Kinase Anchoring Proteins in the Compartmentation in Cyclic Nucleotide Signaling, O. Witczak, E. M. Aandahl, and K. Taskén

Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation in Cardiac Myocytes, A. Abi-Gerges, L. R.V. Castro, F. Rochais, G. Vandecasteele, and R. Fischmeister

Section E

Phosphodiesterases as Pharmacological Targets in Disease Processes

Role of PDEs in Vascular Health and Disease: Endothelial PDEs and Angiogenesis, T. Keravis, A. P. Silva, L. Favot, and C. Lugnier

Regulation of PDE Expression in Arteries: Role in Controlling Vascular Cyclic Nucleotide Signaling, D. H. Maurice and D. G. Tilley

Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases, C. Yan, D. J. Nagel, and K. Jeon

Role of Cyclic Nucleotide Phosphodiesterases in Heart Failure and Hypertension, M. A. Movsesian and C. J. Smith

Molecular Determinants in Pulmonary Hypertension: The Role of PDE5, N.J. Pyne, F. Murray, R. Tate, and M.R. MacLean

Role of PDE5 in Migraine, C. Kruuse

Phosphodiesterase-4 as a Pharmacological Target Mediating Antidepressant and Cognitive Effects on Behavior, H. T. Zhang and J. M. O’Donnell

Role of Phosphodiesterases in Apoptosis, A. Lerner, E. Y.Moon, and S. Tiwari

Section F

Development of Specific Phosphodiesterase Inhibitors as Therapeutic Agents

Crystal Structure of Phosphodiesterase Families and the Potential for Rational Drug Design, K. Y. J. Zhang

Structure, Catalytic Mechanism, and Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases, H. Ke and H. Wang

Bench to Bedside: Multiple Actions of the PDE3 Inhibitor Cilostazol, J. Kambayashi, Y. Shakur, and Y. Liu

Reinventing the Wheel: Nonselective Phosphodiesterase Inhibitors for Chronic Inflammatory Diseases, M. A. Giembycz

Medicinal Chemistry of PDE4 Inhibitors, J. M. McKenna and G. W. Muller Index

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Pharmacy
SCIENCE / Life Sciences / Biology / Molecular Biology