Cytokine Gene Polymorphisms in Multifactorial Conditions: 1st Edition (Hardback) book cover

Cytokine Gene Polymorphisms in Multifactorial Conditions

1st Edition

Edited by Koen Vandenbroeck

CRC Press

488 pages | 45 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9780849336195
pub: 2006-06-21
SAVE ~$51.00
eBook (VitalSource) : 9780429122453
pub: 2006-06-21
from $127.50

FREE Standard Shipping!


The literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes. It discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. The book documents polymorphisms in the most important cytokine genes, or gene clusters, and their biological and genetic effects in a multitude of distinct multifactorial conditions.

Unique to this book are the "disease-centered" chapters examining the role of cytokine gene polymorphisms in a multitude of multifactorial conditions. The conditions include autoimmune or chronic inflammatory diseases, cardiovascular disease, infectious diseases, and longevity. "This section is a real tour de force" (Grant Gallagher and Michael F. Seldin, March 2006).

Broadening the understanding of the effect of genetic variations on human immune responses, the organization, scope, and content of this book make it a valuable and easily accessible resource. The book integrates genetic, immunological, and clinical information and will serve as a reference for novice and expert geneticists, immunologists, cell biologists and clinicians. It is a must for everyone involved in, or planning, cytokine genetics or immunogenetics studies.


"As this volume so capably demonstrates, genetic variation in cytokines, the messengers of the immune system, and their receptors is now recognized as playing an important role in disease susceptibility and outcome…This book is a timely anthology of knowledge, techniques as well as informed speculation…The chapters in this book represent an excellent and timely means of addressing questions related to the study of cytokine gene polymorphisms and will serve as an important reference work.."

- From the foreword by Grant Gallagher and Michael F. Seldin, Editors, "Genes and Immunity", March 2006

Table of Contents


The Biology of Cytokines:General Principles, Properties and Lessons from Animal Models, D. Agnello and M. Gadina

Genetics of Multifactorial Disorders, J.R. Oksenberg and J.D. Rioux

Statistical Approaches to Analysis of Polymorphisms in Multifactorial Conditions, A. Goris and M. de Andrade

Introduction to Integrated Bioinformatic Resources for Cytokine Genetics Research, R. Lazarus

Cytokine Gene Nucleotide Sequence Alignments, J. Bidwell

SNP Genotyping Techniques, P.-Y. Kwok


The IL1 Cluster, T. Pessi, C. Eklund, A. Raitala, and M. Hurme

IL-2 Biology and Polymorphisms in Multifactorial Conditions, F. Matesanz, M. Fedetz, and A. Alcina

The Chromosome 5q23.1 -q31.1 Cluster of Cytokines, T. Laitinen

IL10, R. Lazarus

The IL19 Subfamily of Cytokines, S. Kõks, K. Kingo, E. Vasar, and H. Silm

The IFNG -IL26 -IL22 Cytokine Gene Cluster, K. Vandenbroeck and A. Goris

TNF-a Polymorphisms and Disease, R.M. Gorczynski and I. Boudakov

Macrophage Migration Inhibitory Factor (MIF), Z. Alourfi, D.W. Ray, and R. Donn

Polymorphisms of Chemokines and Their Receptors, B. Puissant, C. Combadière, and E. Lavergne


Asthma and Atopy, J. Karjalainen, M. Virta, K. Ädjers, and M. Hurme

Common Rheumatic Diseases, R. Kilding and A.G. Wilson

Systemic Lupus Erythematosus, S. D 'Alfonso

Sjögren 's Syndrome, M. Pertovaara

Multiple Sclerosis, O.H. Kantarci and B.G. Weinshenker

Type 1 and 2 Diabetes, R. Bergholdt and F. Pociot

Psoriasis, S. Kõks, K. Kingo, E. Vasar, and H. Silm

Diseases of the Gastrointestinal Tract, T. Höhler

Pulmonary Fibrosis, B. Yucesoy and M.I. Luster

Atherosclerosis, G. Candore, S. Vasto, G. Colonna-Romano, D. Lio, M. Carusob, I.M. Rea, and C. Caruso

Longevity, I.M. Rea, G. Candore, L. Cavallone, F. Olivieri, M. Cardelli, C. Franceschi, G. Colonna-Romano, D. Lio, O.A. Ross, and C. Caruso

AIDS, A. Vasilescu, H. Do, and J.-F. Zagury

Tropical Infectious Diseases, T. Quirico-Santos, A.M. Da-Cruz, C. Fernandez Kubelka, J. Lannes-Vieira, and M. Ozório Moraes

Suseptibility to Infection and Severe Disease in Schistosomiasis, V. Arnaud and C. Chevillard


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Immunology
MEDICAL / Pharmacology
SCIENCE / Life Sciences / Genetics & Genomics