Cytokines of the Lung  book cover
1st Edition

Cytokines of the Lung

ISBN 9780824787035
Published September 25, 1992 by CRC Press
664 Pages

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Book Description

Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.

Table of Contents

Introduction -- Preface -- Contributors -- Part I MITOGENIC CYTOKINES -- 1. Platelet-Derived Growth Factor /James P. Fabisiak and Jason Kelley -- I. Introduction -- II. Protein Structure -- III. Gene Structure, Organization, and Processing -- IV. PDGF Receptors -- V. Biological Properties of PDGFs -- VI. Cellular Sources of PDGF -- VII. Regulation of PDGF -- VIII. PDGF in Lung Disease -- IX. Conclusions -- References -- 2. Fibroblast Growth Factors /David Moscatelli -- I. Introduction -- IL History of FGFs -- III. Structural Properties -- IV. FGF Receptors -- V. Interaction with Extracellular Matrix -- VI. Biological Properties -- VIL The Role of FGFs in Tumor Formation -- VIII. FGFs in Lung Biology -- References -- 3. Insulin-Like Growth Factors /Alan D. Stiles, Billie M. Moats-Staats, and George Z. Retsch-Bogart -- I. Introduction -- II. IGF Peptides -- III. IGF Genes and Transcripts -- IV. IGF Receptors -- V. IGF-Binding Proteins -- VI. Actions of IGFs -- VIL Role of IGFs in Fetal Growth -- VIII. Role of IGFs in Postnatal Growth -- IX. IGFs and Lung -- X. Summary -- References -- 4. Transforming Growth Factor-,8 /Jason Kelley -- I. Introduction -- II. The TGF-β Family of Proteins -- III. Biosynthesis of TGF-β -- IV. Gene Structure of TGF-,Bs -- V. Control of TGF-β Gene Expression -- VI. Autoinduction of TGF-β Gene Expression -- VII. Activation of TGF-β Protein -- VIII. Receptors for TGF-β -- IX. Signaling Pathways for TGF-β -- X. TGF-β as a Mitogen -- XL Antiproliferative Effects of TGF-β -- XII. TGF-β and Extracellular Matrix -- XIII. Interactions Between TGF-β and Other Cytokines -- XIV. TGF-β and the Immune System -- xv. TGF-β in Monocyte-Macrophages, Granulocytes, and Mast Cells -- XVI. TGF-β in Fibroblasts -- XVII. Assays for TGF-β -- XVIII. TGF-β in Lung -- XIX. TGF-β in Remodeling and Fibrosis -- xx. Future Directions -- References -- 5. Transforming Growth Factor-a and Epidermal Growth Factor /David K. Madtes -- I. Introduction -- II. The Growth Factor Precursor Molecules -- III. The Growth Factor Genes -- IV. Structure-Function Relationships of the Growth Factors -- V. The EGF Receptor -- VI. Biological Responses to TGF-a and EGF -- VII. The Role of TGF-a and EGF in Lung Development -- VIII. The Role of TGF-a and EGF in Pulmonary Neoplasia -- IX. The Role of TGF-a and EGF in Lung Repair -- X. Conclusion -- References -- Part II PROINFLAMMATORY CYTOKINES -- 6. Interleukin-I /Timothy R. Aksamit and Gary W. Hunninghake -- I. Introduction -- II. Historical Perspective -- III. Structure -- IV. Synthesis -- V. IL-1 Receptor -- VI. Signal Transduction -- VIL IL-1 Inhibitors -- VIII. IL-1 Effects -- IX. Interactions with Other Cytokines -- X. IL-1 and the Lung -- XI. Summary -- References -- 7. lnterleukin-6 and the Lung /Ralph J. Zitnick and Jack A. Elias -- I. Introduction -- II. The IL-6 Protein -- III. The IL-6 Gene: Structure and Regulation -- IV. The IL-6 Receptor -- V. Biological Effects of IL-6 -- VI. IL-6 in Human Homeostasis -- VII. IL-6 in the Lung -- VIII. Summary -- References -- 8. Interleukin-8 /Robert M. Strieter, Theodore J. Standiford, Mark W. Rolfe, and Steven L. Kunkel -- I. Introduction -- II. Chemotactic Factors -- III. Isolation of IL-8 -- IV. Structure of IL-8 -- V. IL-8 Supergene Family -- VI. Physicochemical and Biological Effects of IL-8 -- VII. IL-8 Receptor and Signal Transduction -- VIII. Cytokine Networks and the Expression of IL-8 -- IX. Regulation of IL-8 -- X. The Potential Role of IL-8 in Pulmonary Disease -- References -- 9. Tumor Necrosis Factor /Thomas R. Ulich -- I. The Tumor Necrosis Factors: Historical Review -- II. TNF as a Mediator of Local Inflammation and Septic Shock -- III. Pulmonary Sources of TNF Production -- IV. Target Cells for TNF within the Lung -- V. The Proinflammatory Role of TNF in the Lung In Vivo -- VI. Down-Regulation of TNF -- VIL Summary and Future Directions -- References -- 10. Enzyme-Releasing Peptide /Allen B. Cohen, Edmund J. Miller, and Cassandra MacArthur -- I. Introduction -- II. Neutrophil Granule Enzymes and Their Release -- III. The Enzyme-Releasing Peptide -- IV. Other Similar Agents -- V. Conclusion -- References -- 11. Macrophage Inflammatory Protein-I /Barbara Sherry and Anthony Cerami -- I. Introduction -- II. Isolation, Cloning, and Preliminary Characterization of MIP-1 Peptides -- III. Cloning and Characterization of MIP-la and MIP-1,8 cDNAs -- IV. Proinflammatory Nature of MIP-1 -- V. Modulatory Effects of MIP-1 on Hematopoietic Cell Development -- VI. Preliminary Receptor Characterization of the MIP-1 a and MIP-1,8 Receptors -- VII. Conclusions -- References -- Part III CYTOKINES IN THE LUNG -- 12. Myeloid Growth Factors in the Lung /Jack Gauldie, Mane / Jordana, and Gerard Cox -- I. Colony-Stimulating Factors -- IL Respiratory Cell-Derived CSFs -- III. Effects of CSFs on Immature Inflammatory Cells -- IV. Effects of CSFs on Mature Inflammatory Cells -- V. Implications and Future Directions -- References -- Contents -- 13. Fibroblast-Pneumonocyte Factor /Barry T. Smith and Martin Post -- I. Introduction -- II. Epithelial-Mesenchymal Interactions -- III. Fibroblast-Pneumonocyte Factor -- IV. Conclusion -- References -- 14. Cytokines and Alveolar Type II Cells /Ralph J. Panos -- I. Introduction -- II. Surfactant Synthesis -- III. Surfactant Secretion -- IV. Surfactant Proteins -- V. Type II Cell Proliferation -- VI. Production of Cytokines by Alveolar Type II Cells -- VII. Other Interactions of Cytokines and Type II Cells -- VIII. Conclusions -- References -- Part IV CYTOKINES WITH SPECIAL EFFECTS -- 15. Cytokine-Binding Proteins /James C. Bonner and Arnold R. Brody -- I. Introduction -- II. Cytokine-a-Macroglobulin Interactions -- ill. The Insulin-Like Growth Factor-Binding Proteins -- IV. Other Cytokine-Binding Proteins -- V. Cytokine-Binding Proteins in Lung Disease -- VI. Conclusions -- References -- 16. Cytokine Effects on Extracellular Matrix /Ganesh Raghu and Michael Kinsella -- I. Introduction -- II. Extracellular Matrix in the Normal Lung -- III. Extracellular Matrix in the Abnormal Lung -- IV. Direct Effects of Cytokines on Extracellular Matrix Synthesis -- V. Indirect Effects of Cytokines on Extracellular Matrix Production -- VI. Summary -- VII. Perspectives and Future Directions -- References -- Author Index -- Subject Index.

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Jason Kelley is Professor of Medicine at the University of Vermont College of Medicine, Burlington, and Director of the Medical Intensive Care Unit, Medical Center Hospital of \fermont, Burlington. He is the author or coauthor of more than 60 professional papers, reports, and abstracts that reflect his research interests in cytokines and pulmonary disease. Dr. Kelley is a member of the American Society for Cell Biology, the Biochemical Society, the American Thoracic Society, and the American Association for the Advancement of Science, among other organizations. He received the A.B. degree (1966) in physics from Harvard University, Cambridge, Massachusetts, and the M.D. degree (1972) from the University of Texas Southwestern Medical School at Dallas.