1st Edition

DHEA in Human Health and Aging

Edited By Ronald Ross Watson Copyright 2012
    472 Pages 64 B/W Illustrations
    by CRC Press

    472 Pages 64 B/W Illustrations
    by CRC Press

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    Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, and the mechanisms of action and potential involvement in illnesses remain unclear. DHEA in Human Health and Aging reviews the past ten years of research into this hormone and explores its potential for future study.

    With contributions from a cadre of international experts, this volume examines:

    • The biology of DHEA relevant to health in humans
    • Areas of potential clinical importance concerning low levels of DHEA related to age or physiological change
    • Prevention as well as treatment of various human disease states by changing DHEA levels
    • The use of DHEA levels in predicting the risk of disease
    • The role of DHEA in diabetes, fitness, infectious disease, cancer, AIDS, bone health, cardiovascular diseases, autism, and mental health
    • Animal models and their relation to studies done on humans
    • The effects of loss of adrenal gland function, the subsequent reduction in DHEA production, and its replacement as therapy
    • Adverse effects in DHEA-supplemented women
    • Mechanisms of action of DHEA in prostate and ovarian health, vascular modification, stress, memory, aggression, and Alzheimer’s disease

    Covering a wide range of topics, the book is compiled from contributions of experts who have each studied some aspect of DHEA and human or animal health or disease. Every chapter is self-contained, allowing for focused study on individual topics. Edited by one of the leading experts in the field of nutrition, the book presents a compelling view of the state of the science in DHEA.

    Overviews of Key DHEA Modified Conditions

    DHEA versus Androstenediol in Middle-Aged Women; B. L. Lasley

    DHEA as a Putative Replacement Therapy in the Elderly; A. D. Genazzani and C. Lanzoni

    Prevention of Disease by DHEA

    Dehydroepiandrosterone: Its Metabolites and Resistance to Infections; R. M. Loria and D. Ben-Nathan

    DHEA and Glucose Metabolism in Skeletal Muscle; K. Sato and R. Ajisaka

    DHEA and Dyskinesias; M. Hamann and A. Richter

    Dehydroepiandrosterone: Its Effects on Cell Proliferation and Cancer; R. López-Marure

    Dehydroepiandrosterone and Energy Metabolism; S. S. Katyare and H. R. Modi

    Dehydroepiandrosterone in Human Immunodeficiency Virus Infection Monitoring and Therapy; R. Kannangai and G. Sridharan

    Dehydroepiandrosterone Replacement and Bone Mineral Density; DHEA and Vascular Health and Functions; R. Paulin, E. Dumas De La Roque, and S. Bonnet

    DHEA and Ischemia/Reperfusion Injury Prevention; H. Aksoy

    DHEA and Cancer Risk or Prevention? F. Labrie

    Dehydroepiandrosterone in Intracellular Infectious Diseases and Related Pathogens; N. Galindo-Sevilla and J. Mancilla-Ramírez

    Treatment of Diseases and Physiological Disorders by Dehydroepiandrosterone

    Dehydroepiandrosterone Sulfate and Vascular Remodeling; M. Ii

    DHEA in Human Immunodeficiency Virus Infection: Prognostic and Therapeutic Aspects; C. M. Romero, E. P. Liao, B. Zumoff, and L. Poretsky

    DHEA and Its Metabolites and Analogs: A Role in Immune Modulation and Arthritis Treatment? D. L. Auci, C. N. Ahlem, C. L. Reading, and J. M. Frincke

    Asthma and DHEA; I. S. Choi

    DHEA in Allergy, Asthma, and Urticaria/Angioedema; A. Kasperska-Zajac

    The Role of DHEA in Mental Disorders; I. Pérez-Neri and C. Ríos
    DHEA, Androgen Receptors, and Their Potential Role in Breast Cancer; Z. Nahleh and N.Tageja

    DHEAS and Periodontal Status in Older Japanese; A. Yoshida and T. Ansai

    DHEA Levels and Increased Risk of Atherosclerosis and Cardiovascular Disease; I. Kanazawa and T. Yamaguchi

    DHEAS and Related Factors in Autism; J. Croonenberghs, K. Van Praet, D. Deboutte, and M. Maes

    Animal and In Vitro Model Studies: Future Uses of DHEA

    DHEA Antiviral Properties in Cell Cultures and Animal Models; V. Castilla and M. B. Wachsman

    Adipose Tissue as a Target for Dehydroepiandrosterone and its Sulphate; F. Pérez-de Heredia, J. J. Hernández-Morante, and M. Garaulet

    Dehydroepiandrosterone and Cell Differentiation; A. W. Krug

    DHEA, Oxidative Stress, and Akt; M. H. V. M. Jacob, A. S. R. Araújo, M. F. M. Ribeiro, and A. Belló-Klein

    Evidence for a Cellular DHEA Receptor; B. O’Leary and J. S. Dillon

    DHEA and Mechanisms of Action in Humans

    Dehydroepiandrosterone and Testosterone: Effects on Erectile Function; A. I. El-Sakka

    DHEA Metabolism, Supplementation, and Decline with Age: Role on Prostate Health; J. T. Arnold

    DHEA and Vascular Function; S. Rice and A. Rees

    DHEAS and Coping Capability; C.-H. Kuo

    DHEA and Memory; E. Sujkovic, R. Mileusnic, and J. Fry

    DHEA and Aggression; G. E. Demas, K. K. Soma, and H. E. Albers

    DHEA and Alzheimer’s Disease; L. El Kihel



    Ronald R. Watson, PhD, is a member of several national and international nutrition, immunology, cancer, and alcoholism research societies. For 30 years he was funded by Wallace Research Foundation to study dietary supplements in health promotion. Dr. Watson has edited more than 35 books on nutrition, dietary supplements, and over-the-counter agents, and 53 other scientific books. He has published more than 500 research and review articles. He has done DHEA research in mice for 20 years and has just completed an NIH grant studying DHEA in cardiac function in mice.