Deep Brain Stimulation Indications and Applications

Section 1: Introduction and Humanities

1. Overview of the History and Application of Deep Brain Stimulation

Kristen M. Scheitler, MD, Charles D. Blaha, PhD, and Kendall H. Lee, MD, PhD

2. Ethical Considerations in the Use of Deep Brain Stimulation

Ellery R. Tripp, Osama A. Abulseoud, MD, and Richard R. Sharp, PhD

Section 2: Neural Engineering

3. The Mathematics of Stereotactic Neurosurgery

Jee Won Jennifer Shin, Hojin Shin, PhD, and Kendall H. Lee, MD, PhD

4. Biophysical Fundamentals of Neural Excitation

Jongseo Lee and Kendall H. Lee, MD, PhD

5. Electrochemical Measurements of Neurochemical Concentrations: Dopamine

Jennifer Tang Cabrera, Charles D. Blaha, PhD, Kendall H. Lee, MD, PhD, and Yoonbae Oh, PhD

6. Electrochemical Measurements of Neurochemical Concentrations: Serotonin

Juan Rojas Cabrera, Barbara Hanna, Jennifer Tang-Cabrera, Charles D. Blaha, PhD, Kendall H. Lee, MD, PhD, and Hojin Shin, PhD

7. Closed-Loop Control Systems for Deep Brain Stimulation Therapy

Juan Rojas Cabrera, Hojin Shin, PhD, and Yoonbae Oh, PhD

Section 3: Clinical Applications in Neurology

8. Deep Brain Stimulation for Parkinson’s Disease

Fiona Permezel, MBBS, and Bryan Klassen, MD

9. Deep Brain Stimulation for Tremor

Sara M. Hussein, MD, and Kendall H. Lee, MD, PhD

10. MRI-Guided Focused Ultrasound Therapy for Tremor

Timothy J. Kaufmann, MD, Vance T. Lehman, MD, and Kai J. Miller, MD, PhD

11. Deep Brain Stimulation for Dystonia

Fiona Permezel, MBBS, and Bryan Klassen, MD

12. Current Outcomes of Deep Brain Stimulation for Treatment of Motor Disability in Patients with Cerebral Palsy

Barbara Hanna and Kendall H. Lee, MD, PhD

13. Deep Brain Stimulation for Chronic Pain

Rushna Ali, MD, and Inamullah Khan

14. Motor Cortex Stimulation and Its Applications for Intractable Chronic Pain

Guillermo K. Pons and Kendall H. Lee, MD, PhD

15. Deep Brain Stimulation for Medically Refractory Epilepsy

William S. J. Gibson, MD, PhD, and Damiano G. Barone, MD, PhD

16. Deep Brain Stimulation for Trigeminal Autonomic Cephalalgias

Lucy Simmonds, Manjit Matharu, PhD, FRCP, and Harith Akram, PhD, FRCS

17. Deep Brain Stimulation for Memory Dysfunction

Ugur Sener, MD, Erika K. Ross, PhD, Kevin Bieniek, PhD, and Paul Hoon-Ki Min, PhD

18. Aesthetic Considerations in Deep Brain Stimulation Surgery

Sara M. Hussein, MD, Kendall H. Lee, MD, PhD, Kai J. Miller, MD, PhD, and Basel A. Sharaf, MD, DDS, FACS

Section 4: Clinical Applications in Psychiatry

19. Deep Brain Stimulation for Obsessive-Compulsive Disorder

Charles D. Blaha, PhD, Kristen M. Scheitler, MD, Kendall H. Lee, MD, PhD, and Tyler S. Oesterle, MD, MPH

20. Deep Brain Stimulation for Tourette’s Syndrome

Lydia Hong, Sheng-Ta Tsai, MD, and Kendall H. Lee, MD, PhD

21. Deep Brain Stimulation for Treatment-Resistant Depression

William D. Chow, Kristen M. Scheitler, MD, Kendall H. Lee, MD, PhD, and Tyler S. Oesterle, MD, MPH

22. Anorexia Nervosa and Deep Brain Stimulation: Current Evidence and Future Directions

Sara M. Hussein and Kendall H. Lee, MD, PhD

23. Deep Brain Stimulation for Substance Use Disorder

Kristen M. Scheitler, MD, Kendall H. Lee, MD, PhD, and Tyler S. Oesterle, MD, MPH

24. Deep Brain Stimulation: A Potential Long-Term Therapeutic Modality in Treating Schizophrenia

Sara Vettleson-Trutza, Charles D. Blaha, PhD, Tyler S. Oesterle, MD, MPH, and Kendall H. Lee, MD, PhD

25. Deep Brain Stimulation for Disorders of Consciousness

Juan Rojas Cabrera and Kristen M. Scheitler, MD

26. Deep Brain Stimulation and Its Applications for Post-Traumatic Stress Disorder

Guillermo K. Pons, Kendall H. Lee, MD, PhD, and Maximiliano A. Hawkes, MD

Section 5: Neuroscience of Neuromodulation

27. Motor Circuit Activity in Parkinson’s Disease

Anupama Gupta, Charles D. Blaha, PhD, and Allan Bieber, PhD

28. The Role of Astrocytes in Deep Brain Stimulation

Su-Youne Chang, PhD, and Kendall H. Lee, MD, PhD

29. Anatomy of the Globus Pallidus Internus

Juan P. Navarro-Garcia de Llano, MD, J. Emiliano Sanchez-Garavito, MD, Erik H. Middlebrooks, MD, and Sanjeet S. Grewal, MD

30. STN Anatomic Subregions and Targeting Implications

Vanessa Milanese, MD, Umut Tan Sevgi, MD, and Abuzer Güngör, MD

31. Voltammetric Measurements of Neurochemical Signals in Humans Associated with Behavior, Cognition, and Related Pathologies

Arian Kolahi Sohrabi, BS, P. Read Montague, PhD, and Kenneth T. Kishida, PhD

Biography

Kendall H. Lee is a consultant in the Department of Neurologic Surgery with joint appointments in the Department of Physiology and Biomedical Engineering and the Department of Physical Medicine and Rehabilitation at Mayo Clinic and founder of NaviNetics, Inc, a medical device company.  He joined the staff of Mayo Clinic in 2006. He is the Charles B. and Ann L. Johnson Professor of Neurosurgery and holds the academic rank of professor of biomedical engineering. He also founded Neural Engineering and Precision Surgery Laboratories and is currently a director emeritus at Mayo Clinic. Dr Lee is an expert on neurological disorders and sees patients with Parkinson’s disease, essential tremor, Tourette syndrome, dystonia and other neurodegenerative diseases. His research focuses on developing deep brain stimulation for the treatment of Parkinson's disease, tremor, depression, obsessive-compulsive disorder, and epilepsy. Beyond these movement disorders, his recent research has expanded into the field of psychiatric disorders, and he is actively developing new surgical frames to enhance both surgical precision and patient comfort.

Jin Woo Chang is a professor at Korea University Anam Hospital and the first president of Asian Pacific Society for Transcranial Focused Ultrasound Surgery. He specializes in stereotactic and functional neurosurgery, and his main interest is the neuromodulation of the central nervous system with new innovative techniques, such as electrical stimulation and focused ultrasound. Dr Chang has published more than 270 academic papers in SCI(E) journals around the world. He is a co-author of more than eight prominent neurosurgery textbooks and has authored countless domestic papers and textbooks. Currently Dr Chang serves as a section editor of the journal World Neurosurgery and an editorial board member of the journals Stereotactic and Functional Neurosurgery and Neuromodulation.

“This book covers diverse topics of relevance for current practitioners as well as newcomers to the field, including theoretical and mechanistic aspects, results of important clinical trials, and potential new brain targets and new indications.”

Dr Philip A. Starr

University of California, San Francisco, USA