Jenny Stanford Publishing
486 pages | 47 Color Illus. | 6 B/W Illus.
Deep brain stimulation (DBS) is a widely used therapy for movement disorders such as Parkinson's disease, essential tremor, and dystonia. Its therapeutic success has led to the application of DBS for an increasing spectrum of conditions. However, the fundamental relationships between neural activation, neurochemical transmission, and clinical outcomes during DBS are not well understood.
Drawing on the clinical and research expertise of the Mayo Clinic Neural Engineering Laboratories, this book addresses the history of therapeutic electrical stimulation of the brain, its current application and outcomes, and theories about its underlying mechanisms. It reviews research on measures of local stimulation–evoked neurochemical release, imaging research on stimulation-induced neural circuitry activation, and the state of the art on closed-loop feedback devices for stimulation delivery.
"Kendall Lee and colleagues have curated an approachable and comprehensive overview of deep brain stimulation (DBS), with topics ranging from the biophysics of neural stimulation to applications of DBS for both established and emerging clinical indications, including memory dysfunction. Also notable are discussions of active research, such as closed loop stimulation and in vivo neurochemical monitoring. This text provides an invaluable companion for clinicians, neuroscientists, engineers, and others with an interest in the current practice and frontiers of DBS."
—Dr. Emad Eskandar, Massachusetts General Hospital, Harvard Medical School, USA
"The field of therapeutic deep brain stimulation is undergoing explosive growth, fueled by its early success in movement disorders and promise for many other common and debilitating brain disorders. Yet the mechanisms underlying its effects remain mysterious. This book covers diverse topics of relevance for current practitioners as well as newcomers to the field, including theoretical and mechanistic aspects, results of important clinical trials, and potential new brain targets and new indications."
—Dr. Philip A. Starr, University of California, San Francisco, USA
"This book is an important reference to the field of stereotactic and functional neurosurgery and covers the most important aspects of clinical practice and research in deep brain stimulation. It will be of great interest to those who are new to this field as well as experienced clinicians and investigators. Among many important topics, the book covers biophysical fundamentals of electrical stimulation, anatomy and physiology of neural networks relevant to movement disorders, chronic pain and behavioral disorders, ethical considerations, current indications of deep brain stimulation, and many areas of active clinical investigation."
—Dr. André Machado, Cleveland Clinic, USA
"This book provides a comprehensive, up-to-date description of deep brain stimulation, including its history, scientific basis, and clinical application across a vast array of neurological disorders. Although the authors are primarily from a single institution, they have done a terrific job of summarizing the state of the art, including the victories, the disappointments, and the opportunities where breakthroughs are likely next to occur. This book has tremendous value for the novice and experienced practitioner alike."
—Dr. Jonathan Miller, University Hospitals, USA
INTRODUCTION TO DEEP BRAIN STIMULATION
Overview of the History and Application of Deep Brain Stimulation
Kendall H. Lee, Penelope S. Duffy, and Charles D. Blaha
Biophysical Fundamentals of Neural Excitation
Susanne Loffler and J. Luis Luján
Motor Circuit Activity in Parkinson’s Disease
Allan J. Bieber
Neuroimaging in Deep Brain Stimulation
Hoon-Ki Min, Erika Ross, and Megan Settell
Ethical Considerations in the Use of Deep Brain Stimulation
Alexander Fiksdal, Osama A. Abulseoud, and Richard R. Sharp
Deep Brain Stimulation for Parkinson’s Disease
Bryan T. Klassen
Deep Brain Stimulation for Tremor
Andrea C. Adams
Deep Brain Stimulation for Dystonia
Nicholas D. Child and Bryan T. Klassen
Deep Brain Stimulation for Obsessive-Compulsive Disorder
Prakriti Gaba and Charles D. Blaha
Deep Brain Stimulation for Touret te’s Syndrome
Hoon-Ki Min, Megan Settell, and Paola Testini
Deep Brain Stimulation for Treatment-Resistant Depression
Yesul Kim, Katheryn M. Wininger, and Susannah J. Tye
Deep Brain Stimulation for Chronic Pain
Grant W. Mallory and Prakriti Gaba
Deep Brain Stimulation for Medically Refractory Epilepsy
William S. J. Gibson and Penelope S. Duffy
Deep Brain Stimulation for Memory Dysfunction
Erika K. Ross, Kevin F. Bieniek, and Hoon-Ki Min
Deep Brain Stimulation for Cluster Headache
Cong Zhi Zhao
Functional Electrical Stimulation for the Treatment of Spinal Cord Injury
Peter J. Grahn, Aldo A. Mendez Ruiz, Jan T. Hachmann, and J. Luis Luján
RESEARCH ON MECHANISMS OF DBS AND NEUROMODULATION
Theories of Deep Brain Stimulation Mechanisms
Charles D. Blaha
The Role of Astrocytes in Deep Brain Stimulation
Su-Youne Chang and Kendall H. Lee
Electrochemical Measurement of Neurochemical Concentrations
Kevin E. Bennet, Charles D. Blaha, and Kendall H. Lee
Electrodes for Neural Stimulation and Monitoring
Jonathan R. Tomshine and Kevin E. Bennet
Closed-Loop Control Systems for Deep Brain Stimulation Therapy
James K. Trevathan and J. Luis Lujan
Molecular and Cellular Neuromodulation for Central Nervous System Injury and Regeneration
Lucas P. Carlstrom