Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient.
With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
1. Repair after Spinal Cord Injury: A Clinical Perspective 2. Recovery from Injury in the Immature Mammalian Spinal Cord 3. Intrinsic Determinants of Differential Axonal Regeneration by Adult Mammalian Central Nervous System Neurons 4. Inflammation and the Glial Scar: Factors at the Site of Injury that Influence Regeneration in the Cental Nervous System 5. Intrinsic Neuronal and Extrinsic Glial Determinants of Axonal Regeneration in the Injured Spinal Cord 6. Evolutionary Hierarchy of Optic Nerve Regeneration: Implications for Cell Survival, Axon Outgrowth and Map Formation 7. Regeneration in the Central Nervous System: Mechanisms and Strategies for Enhancement 8. What Types of Bridges will Best Promote Anoxal Regeneration Across an Area of Injury in the Adult Mammalian Spinal Cord? 9. Use of Cell/Polymer Hybrid Structures as Conduits for Regenerative Growth in the Central Nervous System 10. Neural Stem Cell: Regulation and Potential Use in Neuronal Regeneration 11. The Low Affinity Neurotrophin, p75: A Multifunction Molecule with a Role in Nerve Regeneration? 12. Regeneration in the Peripheral Nervous System 13. The Role of Macrophages in Degeneration and Regeneration in the Peripheral Nervous System 14. The Response of the Somatosensory System to Peripheral Nerve Injury