Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects.
Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer’s disease and other dementias, Parkinson’s disease and related disorders, and Huntington’s disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation.
Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.
Chapter 1 – Brain circuitry and ageing in neurodegenerative disease
Chapter 2 – Alzheimer’s Disease: Prodromal Stages and Dementia
Chapter 3 – Parkinson’s disease
Chapter 4 – Huntington’s disease
Chapter 5 – Experience-dependent modulation of neurodegenerative disorders: Huntington’s disease as an exemplar
Chapter 6 – Fragile X-associated tremor ataxia syndrome
Chapter 7 – Multiple sclerosis
Chapter 8 – Dementia with Lewy Bodies
Chapter9 – Motor Neuron Disease
Chapter10 – New clinical neuroscience technologies for treating neurodegenerative disorders
Chapter 11 – Conclusions and last thoughts