Degenerative Disorders of the Brain  book cover
1st Edition

Degenerative Disorders of the Brain

ISBN 9780815382263
Published April 16, 2019 by Routledge
276 Pages

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Book Description

Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects.

Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer’s disease and other dementias, Parkinson’s disease and related disorders, and Huntington’s disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation.

Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.

Table of Contents



Chapter 1 – Brain circuitry and ageing in neurodegenerative disease


Chapter 2 – Alzheimer’s Disease: Prodromal Stages and Dementia


Chapter 3 Parkinson’s disease


Chapter 4 Huntington’s disease


Chapter 5 Experience-dependent modulation of neurodegenerative disorders: Huntington’s disease as an exemplar

Chapter 6 – Fragile X-associated tremor ataxia syndrome

Chapter 7Multiple sclerosis


Chapter 8 Dementia with Lewy Bodies


Chapter 9 Motor Neuron Disease

Chapter 10 New clinical neuroscience technologies for treating neurodegenerative disorders


Chapter 11Conclusions and last thoughts


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Darren R. Hocking is a Senior Research Fellow and ARC DECRA Fellow at La Trobe University, Australia.

John L. Bradshaw is Emeritus Professor of Neuropsychology at Monash University, Australia.

Joanne Fielding is Associate Professor in the Central Clinical School at Monash University, Australia.