Dermatokinetics of Therapeutic Agents: 1st Edition (Paperback) book cover

Dermatokinetics of Therapeutic Agents

1st Edition

Edited by S. Narasimha Murthy

CRC Press

228 pages | 15 Color Illus. | 71 B/W Illus.

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Description

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders.

Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents.

Topics include:

  • Theoretical Models for Dermatokinetics of Therapeutic Agents
  • Drug Delivery Approaches to Modulate Dermatokinetics of Drugs
  • Conventional Methods of Cutaneous Drug Sampling
  • Cutaneous Microdialysis
  • Sampling Substrates by Skin Permeabilization
  • Spectroscopic Techniques in Dermatokinetics Studies
  • Regulatory Perspective of Dermatokinetic Studies

Table of Contents

Introduction to Dermatokinetics

Skin Tissue and the Extracellular Fluid

Fate of Therapeutic Agents in Skin

Distribution of Drugs in the Skin

Biochemistry of Cutaneous Tissue and Biotransformation of Drugs

Dermatokinetics of Drugs and Dermatopharmacology

Dermatokinetics of Drugs and Dermatotoxicology

Theoretical Models for Dermatokinetics of Therapeutic Agents

Introduction to Fundamentals of Pharmacokinetics

Theoretical Models of Dermatokinetics of Drugs

Two Compartment Model

Physiologically Based Pharmacokinetic Model

Drug Delivery Approaches to Modulate Dermatokinetics of Drugs

Drug Delivery Systems and Dermatokinetics

Salts, Prodrugs, and Complexes

Physiological Approaches to Dermatokinetics of Drugs

Cutaneous Sustained Release Drug Delivery Systems

Carrier Mediated Drug Delivery Systems

Physically Mediated Drug Delivery

Target Deliver to Skin

Conventional Methods of Cutaneous Drug Sampling

Introduction to Drug Sampling Techniques and their use in Dermatokinetics Studies of Drugs

Tape Stripping Method of Drug Sampling

Skin Biopsy Sampling

Skin Blister Fluid Sampling

Cutaneous Microdialysis

Basics of Cutaneous Tissue Microdialysis and Methods of Probe Calibration

Probes Used in Cutaneous Microdialysis

Common Procedural Issues, Troubleshooting, and Optimization Approaches

Sampling Substrates by Skin Permeablization

Introduction to Transcutaneous Sampling of Drugs

Reverse Iontophoresis

Electroporation Mediated Drug Sampling

Sonoporesis Mediated Sampling

Cutaneous Sampling by Microneedles

Spectroscopic Techniques in Dermatokinetics Studies

Introduction to Fundamentals of Spectroscopic Techniques Used in Dermatokinetics Studies

Fluorescence Detection Skin Drug Levels

ATR FTIR Detection of Drug in Skin

Raman Spectroscopy

Dermatokinetics of Gene Therapeutics

Gene Therapeutics and Cutaneous Gene Therapy

Pharmacogenetics of Gene Therapeutics in Skin

Regulatory Perspective of Dermatokinetic Studies

Skin Bioavailability and Bioequivalence Studies

FDA Guidelines for Dermatokinetic Studies

About the Editor

S. Narasimha Murthy is an Assistant Professor of Pharmaceutics at the University of Mississippi.

Subject Categories

BISAC Subject Codes/Headings:
MED017000
MEDICAL / Dermatology
MED071000
MEDICAL / Pharmacology
MED072000
MEDICAL / Pharmacy
SCI013000
SCIENCE / Chemistry / General