Dermatokinetics of Therapeutic Agents  book cover
SAVE
$17.99
1st Edition

Dermatokinetics of Therapeutic Agents





ISBN 9781138114586
Published September 12, 2017 by CRC Press
228 Pages 15 Color & 71 B/W Illustrations

 
SAVE ~ $17.99
was $89.95
USD $71.96

Prices & shipping based on shipping country


Preview

Book Description

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders.

Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents.

Topics include:

  • Theoretical Models for Dermatokinetics of Therapeutic Agents
  • Drug Delivery Approaches to Modulate Dermatokinetics of Drugs
  • Conventional Methods of Cutaneous Drug Sampling
  • Cutaneous Microdialysis
  • Sampling Substrates by Skin Permeabilization
  • Spectroscopic Techniques in Dermatokinetics Studies
  • Regulatory Perspective of Dermatokinetic Studies

Table of Contents

Introduction to Dermatokinetics
Skin Tissue and the Extracellular Fluid
Fate of Therapeutic Agents in Skin
Distribution of Drugs in the Skin
Biochemistry of Cutaneous Tissue and Biotransformation of Drugs
Dermatokinetics of Drugs and Dermatopharmacology
Dermatokinetics of Drugs and Dermatotoxicology

Theoretical Models for Dermatokinetics of Therapeutic Agents

Introduction to Fundamentals of Pharmacokinetics
Theoretical Models of Dermatokinetics of Drugs
Two Compartment Model
Physiologically Based Pharmacokinetic Model

Drug Delivery Approaches to Modulate Dermatokinetics of Drugs

Drug Delivery Systems and Dermatokinetics
Salts, Prodrugs, and Complexes
Physiological Approaches to Dermatokinetics of Drugs
Cutaneous Sustained Release Drug Delivery Systems
Carrier Mediated Drug Delivery Systems
Physically Mediated Drug Delivery
Target Deliver to Skin

Conventional Methods of Cutaneous Drug Sampling

Introduction to Drug Sampling Techniques and their use in Dermatokinetics Studies of Drugs
Tape Stripping Method of Drug Sampling
Skin Biopsy Sampling
Skin Blister Fluid Sampling

Cutaneous Microdialysis

Basics of Cutaneous Tissue Microdialysis and Methods of Probe Calibration
Probes Used in Cutaneous Microdialysis
Common Procedural Issues, Troubleshooting, and Optimization Approaches

Sampling Substrates by Skin Permeablization

Introduction to Transcutaneous Sampling of Drugs
Reverse Iontophoresis
Electroporation Mediated Drug Sampling
Sonoporesis Mediated Sampling
Cutaneous Sampling by Microneedles

Spectroscopic Techniques in Dermatokinetics Studies

Introduction to Fundamentals of Spectroscopic Techniques Used in Dermatokinetics Studies
Fluorescence Detection Skin Drug Levels
ATR FTIR Detection of Drug in Skin
Raman Spectroscopy

Dermatokinetics of Gene Therapeutics

Gene Therapeutics and Cutaneous Gene Therapy
Pharmacogenetics of Gene Therapeutics in Skin

Regulatory Perspective of Dermatokinetic Studies

Skin Bioavailability and Bioequivalence Studies
FDA Guidelines for Dermatokinetic Studies

...
View More

Editor(s)

Biography

S. Narasimha Murthy is an Assistant Professor of Pharmaceutics at the University of Mississippi.