Dermatotoxicology  book cover
8th Edition


ISBN 9781841848556
Published September 27, 2012 by CRC Press
518 Pages

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Book Description

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances.

This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.

Table of Contents

I: Concepts  1. Pharmacogenetics and dermatology  2. Hormesis and dermatology  3.Toward an evidence-based dermatotoxicology  4. How to improve skin notation  5. Skin ion channels in health and disease  II: Systemic Toxicity  6. Systemic toxicity  7. Chemical respiratory allergy: opportunities for hazard identification and characterization  8. Nephrotoxicity of organic solvents from skin exposure  9. Mechanisms in cutaneous drug hypersensitivity reactions  10. Systemic allergic (contact) dermatitis  III: Local  Toxicity  11. Immunological mechanisms in irritant and allergic contact dermatitis  12. Allergic contact dermatitis: elicitation thresholds of potent allergens in humans  13. Photoirritation  14. Contact urticaria syndrome  IV:  Compounds  15. Percutaneous penetration enhancers: overview  16. Chemical warfare agents  17. Allergic contact dermatitis from ophthalmics  18. Textiles and human skin, microclimate, and cutaneous reactions: overview  19. Identifying the source of textile-dye allergic contact dermatitis: a guideline   20. Trichloroethylene dermatotoxicology: an update  21. Chemical agents that cause depigmentation  22. Hydroxychloroquine-induced retinopathy  23. Factors influencing applied amount of topical preparations  24. Immune reactions to copper  25. Sodium lauryl sulfate  26. Water: is it an irritant? 27. In vivo human transfer of topical bioactive drugs among individuals: estradiol and testosterone 28. Depigmentation changes as a result of arsenic exposure  V: Susceptibility of Different Populations  29. Gender and pharmacokinetics  30. Dermatological drug usage in the elderly  31. Sensitive skin: A valid syndrome of multiple origins  32. Dermatotoxicology of the vulva  33. Human scalp irritation related to arm and back  34. Functional map and age-related differences in human faces: nonimmunologic contact urticaria induced by hexyl nicotinate  35. Adhesive tape stripping reveals differences in stratum corneum cohesion between Caucasians, Blacks and Hispanics as a function of age  VI: Methods  36. Animal, human, and in vitro test methods for predicting skin irritation  37. Physiologically based pharmacokinetic modelling of dermal absorption  38. In vitro approaches to assessment of skin irritation and phototoxicity of topically applied materials  39. The local lymph node assay  40. Utilization of irritation data in local lymph node assay  41. Failure of standard test batteries for detection of genotoxic activity of some chemicals used in dermatological and cosmetic products  42. Determination of chromium and nickel allergy, sensitization, and toxicity by cellular in vitro methods  43. Methods for in vitro skin metabolism  44. In vitro model for decontamination of human skin: formaldehyde  45. Percutaneous absorption of hazardous substances from soil and water  46. Stratum corneum tape stripping method: an update   47. The diagnostic value of patch testing  48. Diagnostic tests in dermatology: patch and photopatch testing and contact urticaria  49. Photoirritation (phototoxicity or phototoxic dermatitis)  50. Significance of methyl mercury hair analysis: mercury biomonitoring in human scalp/nude mouse model  51. Use of modified forearm controlled application text to evaluate skin irritation of lotion formulations  52. Evaluating mechanical and chemical irritation using the behind-the-knee test: a review  53. Tests for sensitive skin  54. Dermatotoxicity of specialized epithelia: adapting cutaneous test methods to assess topical effects on the vulva  55. Biomarkers associated with severe cutaneous adverse reactions  VII: Treatment  56. Decreasing allergic contact dermatitis frequency through dermatotoxicologic and epidermic-based intervention 57. The importance of the skin decontamination wash-in effect  58. Water decontamination of chemical skin and eye splashes: a critical review  59. Irritant and allergic contact dermatitis treatment  60. Anti-irritants: myth or reality? An overview  VIII: Regulatory Aspects and Guidelines  61. Validation and regulatory acceptance of dermatotoxicology methods: recent progress and the role of NICEATM and ICCVAM  62. Safety and efficacy information in drug inserts for topical prescription medications  63. Lack of drug interaction conformity in commonly used drug compendia for selected at-risk dermatologic drugs  64. OECD guidelines for testing of chemicals  65. Dermatologic drugs withdrawn by the FDA for safety reasons

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Klaus-Peter Wilhelm, M.D., is extraordinary professor of dermatology at the University of Lübeck, Germany, and president and medical director of proDERM Institute for Applied Dermatological Research Schenefeld/Hamburg, Germany. He is president of the International Society for Biophysics and Imaging of the Skin, and a member of several scientific associations and societies. He has published over 100 manuscripts and reviews and coauthored three books in the bioengineering of the skin series. Dr. Wilhelm received an M.D. from the Medical University of Lübeck, Germany.

Hongbo Zhai, M.D., is a senior research fellow at the Department of Dermatology in the University of California at San Francisco. He has over two decades of experience in the prevention of contact dermatitis and the development of skin-disease-related products. He has contributed to the development of innovative skin-related products in collaboration with many global pharmaceutical and cosmetic companies. He has published more than 100 scientific articles in his research areas. Dr. Zhai is also the 2003 winner of the international “Niels Hjorth Prize.”

Howard I. Maibach, M.D., is professor of dermatology in the School of Medicine at the University of California, San Francisco. He has several decades of research experience in skin diseases and the development of skin-related products. He has published more than 2,000 papers and over 80 textbooks. He is a consultant to government agencies, universities, and industry.


"All chapters provide comprehensive and up-to-date coverage of the topic of interest, in an easily readable and consistent style and are very well referenced … Overall, the authors have achieved their goal of providing a comprehensive and systematic resource …"
—Anna Trakoli in Occupational Medicine