Design and Analysis of Clinical Trials with Time-to-Event Endpoints

Overview of Time-to-Event Endpoint Methodology Karl E. Peace

Design (and Monitoring) of Clinical Trials with Time-to-Event Endpoints Michael W. Sill and Larry Rubinstein

Overview of Time-to-Event Parametric Methods Karl E. Peace and Kao-Tai Tsai

Overview of Semiparametric Inferential Methods for Time-to-Event Endpoints Jianwen Cai and Donglin Zeng

Overview of Inferential Methods for Categorical Time-to-Event Data Eric V. Slud

Overview of Bayesian Inferential Methods Including Time-to-Event Endpoints Laura H. Gunn

An Efficient Alternative to the Cox Model for Small Time-to-Event Trials Devan V. Mehrotra and Arthur J. Roth

Estimation and Testing for Change in Hazard for Time-to-Event Endpoints Rafia Bhore and Mohammad Huque

Overview of Descriptive and Graphical Methods for Time-to-Event Data Michael O’Connell and Bob Treder

Design and Analysis of Analgesic Trials Akiko Okamoto, Julia Wang, and Surya Mohanty

Design and Analysis of Analgesic Trials with Paired Time-to-Event Endpoints Zhu Wang and Hon Keung Tony Ng

Time-to-Event Endpoint Methods in Antibiotic Trials Karl E. Peace

Design and Analysis of Cardiovascular Prevention Trials Michelle McNabb and Andreas Sashegyi

Design and Analysis of Antiviral Trials Anthony C. Segreti and Lynn P. Dix

Cure Rate Models with Applications to Melanoma and Prostate Cancer Data Ming-Hui Chen and Sungduk Kim

Parametric Likelihoods for Multiple Nonfatal Competing Risks and Death, with Application to Cancer Data Peter F. Thall and Xuemei Wang

Design, Summarization, Analysis, and Interpretation of Cancer Prevention Trials Matthew C. Somerville, Jennifer B. Shannon, and Timothy H. Wilson

LASSO Method in Variable Selection for Right-Censored Time-to-Event Data with Application to Astrocytoma Brain Tumor and Chronic Myelogenous Leukemia Lili Yu and Dennis Pearl

Selecting Optimal Treatments Based on Predictive Factors Eric C. Polley and Mark J. van der Laan

Application of Time-to-Event Methods in the Assessment of Safety in Clinical Trials Kelly L. Moore and Mark J. van der Laan

Design and Analysis of Chronic Carcinogenicity Studies of Pharmaceuticals in Rodents Mohammad Atiar Rahman and Karl K. Lin

Design and Analysis of Time-to-Tumor Response in Animal Studies: A Bayesian Perspective Steve Thomson and Karl K. Lin

Index

Biography

Karl E. Peace is Georgia Cancer Coalition Distinguished Cancer Scholar (GCCDCS), Senior Research Scientist, and Professor of Biostatistics in the Jiann-Ping Hsu College of Public Health (JPHCOPH) at Georgia Southern University. In addition to his many endowments and awards, Dr. Peace has made critical contributions to the development and approval of drugs to treat Alzheimer’s disease, prevent gastrointestinal ulcers, reduce the risk of myocardial infarction, and treat anxiety/depression.

… One of the strengths of the book is the collection, discussion and illustration of the many diverse time-to-event problems that may occur in practice. … this publication provides a comprehensive overview of classical and emerging ideas in the analysis of time-to-event problems. Written by experts in their area, the book has a wealth of references in each topic should the reader wish to learn about or extend their understanding of individual concepts or analysis methods. It is a worthwhile book to have in the library for anyone working in designing, conducting, analysing or interpreting studies with time-to-event outcomes.
—Australian & New Zealand Journal of Statistics, 2011