1st Edition
Design of Caspase Inhibitors as Potential Clinical Agents
312 Pages
by
CRC Press
312 Pages
by
CRC Press
312 Pages
by
CRC Press
Also available as eBook on:
Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells – the body’s self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors... Read more
Mammalian Caspase Activation Pathways in Apoptosis and Inflammation. Role of Caspases in Inflammation-Driven Diseases. Role of Caspases in Apoptotic-Driven Indications. Kinetics and Catalytic Activity of Caspases. Nonpeptide Small Molecule Inhibitors of Caspases. Identification of Inflammatory Caspase Inhibitors. Identification of Apoptotic Caspase Inhibitors. Discovery of a First-in-Class Apoptotic Caspase Inhibitor. Emricasan (PF-03491390/IDN-6556). Novel Approaches to Caspase Inhibitor Discovery. Therapeutic Potential for Caspase Inhibitors: Present and Future. Index.
Biography
Tom O’Brien, Steven D. Linton
