Developmental Immunotoxicology: 1st Edition (Hardback) book cover

Developmental Immunotoxicology

1st Edition

Edited by Steven D. Holladay

CRC Press

384 pages | 50 B/W Illus.

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Hardback: 9780415284578
pub: 2004-11-15
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Description

Despite rapidly increasing interest in developmental immunotoxicology, there is not yet a textbook focused on this hot area of research. Developmental Immunotoxicology fills the void with overviews of immune system development in experimental animal and human models, and discusses the complex issues related to the evolution of developmental immunology and risk assessment.

This text describes different models used to study developmental immunotoxicology and examples of specific developmental immunotoxic agents, including therapeutics. The text concludes with several chapters that describe the role of neuroimmune interactions as they relate to developmental immunotoxicology.

Using a didactic approach, Developmental Immunotoxicology provides an explanatory overview of this cutting-edge field for toxicologists, immunologists, and developmental biologists. It provides a lucid account of this area of research-proposing answers to some questions and stimulating debate on those questions yet to be addressed by the research community.

Reviews

"This book is the first to consider developmental immunotoxicology … an extremely important contribution to the toxicology literature. … [It] is also timely and provides a treatment of a major current scientific and regulatory issue … a text of high educational and reference value to toxicologists at all levels and across numerous disciplines. … [It] will undoubtedly be influential, as both science and regulatory risk assessment uncover the scale of a potential major human health problem."

- Journal of Applied Toxicology

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Table of Contents

DEVELOPMENT OF THE IMMUNE SYSTEM

Development of the Rodent Immune System; K.S. Landreth and S.V.M. Dodson

Development of the Human Immune System; R. Leibnitz

DEVELOPMENTAL IMMUNOTOXICOLOGY: MODELS

Risk Assessment Perspectives for Developmental Immunotoxicology; C.A. Kimmel, M.D. King, and S.L. Makris

The Mouse as a Model for Developmental Immunotoxicology; M.R. Prater, B.L. Blaylock, and S.D. Holladay

The Rat as a Model for Developmental Immunotoxicology; R.J. Smialowicz

The Pig as a Model for Developmental Immunotoxicology; H.J. Röthkotter, E. Sowa, and R. Pabst

The Non-Human Primate as a Model for Developmental Immunotoxicology; A.G. Hendrickx, P. Peterson, and N. Makori

DEVELOPMENTAL IMMUNOTOXICANT EXPOSURE AND POSTNATAL IMMUNOSUPRESSION

Developmental Immunotoxicology of Halogenated Aromatic Hydrocarbons and Polycyclic Aromatic Hydrocarbons; T.C. Hrubee, B.L. Blaylock, and S.D. Holladay

Developmental Immunotoxicity of Chlordane; J.B. Barnett, L.F. Gibson, and K.S. Landreth

Toxicity of Lead to the Developing Immune System; R.R. Dietert and J.-E. Lee

Developmental Immunotoxicity of Therapeutic Immunosuppressive Drugs; R.M. Gogal, Jr. and S.D. Holladay

Mycotoxins and Other Miscellaneous Developmental Immunotoxicants; T.C. Hrubec and S.D. Holladay

DEVELOPMENTAL IMMUNOTOXICANT EXPOSURE AND EXACERBATED POSTNATAL IMMUNE RESPONSES

Prenatal Immunotoxicant Exposure and Autoimmune Disease; B.L. Blaylock, S.A. Ahmed, and S.D. Holladay

Developmental Immunotoxicant Exposure and Exacerbated Postnatal Immune Responses: Asthma; J.M. Armstrong, R.R. Leibnitz, and D. Loer-Martin

NEUROIMMUNE INTERACTIONS

Developmental Neurotoxicity and Postnatal Immune Deficits; P.V. Basta

Neuroendocrine-Immune Interactions: Impact of Gender, Negative Energetic Balance Condition, and Developmental Stage on the Mechanisms of the Acute Phase Response of the Inflammatory Process in Mammals, E. Spinedi, N.B. Pérez, and R.C. Gaillard

Subject Categories

BISAC Subject Codes/Headings:
MED044000
MEDICAL / Immunology
MED096000
MEDICAL / Toxicology
SCI072000
SCIENCE / Life Sciences / Biology / Developmental Biology