Diabetes has garnered worldwide attention and research funding as clinicians and researchers seek to better understand its pathogenesis, prevention, complications management, and impact and relationship to other diseases (heart disease, kidney disease, infections, and inflammation). Clinicians are overwhelmed with rapidly evolving developments regarding the science and clinical management of diabetes and are struggling to understand and apply new diabetes information.
This book will provide a concise interpretation of translational diabetes research for the purpose of preparing clinicians to understand and effectively deploy new strategies and therapeutics into the clinical care of diabetes patients by examining:
the contrast between existing information in the clinical practice versus the basis and need for future clinical trials
breakthroughs within clinical trials and methods to incorporate bench to bedside material for the clinical practice
the synthesis and interpretation of the scientific principles, trial results, and clinical implications of emerging and translational therapies, and the management strategies for diabetic patients
the entire scope of translational diabetes research from biology to screening and prognosis, new therapeutics, insulin, transplantation, and complications management
new therapeutic strategies to knowledgeably and effectively equip the practicing clinician
assembles information that is scattered throughout the diabetic community into one concise single reference
Table of Contents
Problems with the definition of diabetes: closing the gap between type 1 and type 2. How do we screen for and predict autoimmune diabetes? How do we screen for and predict autoimmune diabetes? How do we screen for and predict non-autoimmune diabetes? How do we screen for and predict non-autoimmune diabetes? What are the prospects for preventing autoimmune diabetes? How can we use genetic information in the clinic? Neural and endocrine control of satiety and energy metabolism. Insulin resistance; new approaches to detection and treatment. Adipokines. Incretins. Retinopathy. Cardiovascular disease. Transplantation. Creation and generation of B cells. Technologies for insulin delivery and glucose monitoring. Diabetes Complications: Molecules to Management.
CARLA J. GREENBAUM is director of the Diabetes Program and the Clinical Research Center at Benaroya Research Institute, Seattle, Washington, USA. She received her MD from Brown University, Providence, Rhode Island, USA. Dr. Greenbaum has been a leader in clinical investigations and trials to prevent or intervene with the diabetes autoimmune process, contributing to over 100 book chapters, abstracts, and journals. She currently serves as Vice-Chair of Type 1 Diabetes TrialNet, an NIH sponsored international consortium to conduct multiple clinical trials in Type 1 diabetes, Director of the North American Network of the Type 1 Diabetes Genetics Consortium (NIH), and as a member of the Clinical Trials Advisory Group and Scientific Review Committee of the NIH sponsored Immune Tolerance Network. Dr. Greenbaum is a member of the Board of Directors of the Diabetes Vaccine Development Center (Australia) and the Clinical Affairs Advisory Committee for JDRF, as well as serving on many review committees focused on clinical and translational research.
LEONARD C. HARRISON is Head of the Division of Autoimmunity and Transplantation at The Walter and Eliza Hall Institute of Medical Research, and Professor/Director of The Burnet Clinical Research Unit and Department of Clinical Immunology, The Royal Melbourne Hospital, Parkville, Victoria, Australia. He graduated in medicine from the University of New South Wales, Sydney, and obtained his M.D. and D.Sc from the University of Melbourne, Australia. He has been awarded various honors, including the Wellcome Glaxo Australia Medal and the David Rumbough Award from the Juvenile Diabetes Research Foundation International. Dr. Harrison has been Chairman of the Professional Advisory Panel of the Juvenile Diabetes Foundation Australia, President of the Australian Diabetes Society and President of the Immunology of Diabetes Society. He holds nine patents and has contributed to 450 original refereed papers, reviews, books, b