1st Edition

Dimethyl Sulfoxide (DMSO) in Trauma and Disease

    272 Pages
    by CRC Press

    270 Pages 10 Color & 30 B/W Illustrations
    by CRC Press

    First isolated as a chemical compound by a Russian chemist in 1866, dimethyl sulfoxide (DMSO) proved to be a near-perfect solvent for decades before its remarkable biological and medical activities were discovered. DMSO is one of the most prodigious agents ever to come out of the world of drug development. Its wide range of biological actions involving plants, animals, and humans has led to the publication of tens of thousands of articles in the scientific literature.

    Dimethyl Sulfoxide (DMSO) in Trauma and Disease examines the major clinical uses of DMSO in humans as supported by basic evidence derived from experiments in animals, including its effects in disorders such as osteoarthritis, interstitial cystitis, gastrointestinal inflammatory changes, scleroderma, respiratory distress, myasthenia gravis, cardiac disease, traumatic brain injury, and Alzheimer’s disease.

    The effects of DMSO on pain, cancer, stroke, and spinal cord injury are also discussed. The book explores how its chemical structure is able to react and deactivate toxic molecules generated by DNA damage, free radical formation, inflammation, oxidation, and infection. For the first time, the collective data on the biological, chemical, and medical actions of DMSO are presented and analyzed from the published scientific literature.

    Clearly written, the book incorporates easy-to-understand scientific descriptions that appeal both to health care professionals and the millions of people worldwide who have used DMSO for an assortment of ailments as a prescriptive or off-label medication.

    Chemistry of DMSO
    Chemical Structure and Properties of DMSO
    DMSO Solvation and Chemical Activity
    Protein Folding
    Permeability Enhancement
    DMSO as a Chemical Chaperone
    DMSO as an Electrolyte
    DMSO in the Sea and the Atmosphere

    DMSO in Basic Pharmacology

    Absorption, Fate, and Excretion of DMSO
    Chemical Chaperones
    DMSO as a Pain Medication
    Cardiac Disease
    Ulcerative Colitis
    Skin Penetrant
    Wound Healing
    Burns and Scar Tissue
    Respiratory Stimulation
    Acute Respiratory Distress Syndrome
    Experimental Blunt Chest Trauma
    Cholinesterase Inhibition
    Solvent Action
    Veterinary Uses
    Teratology and LD
    Ocular Effects
    Intrawound Administration of DMSO

    DMSO Clinical Pharmacology

    DMSO in Disease
    Interstitial Cystitis
    Gastrointestinal Disorders
    Autoimmune Disorders
    Amyloidosis and Scleroderma
    Thromboembolic Events
    Platelet Deaggregation and Free Radical Scavenging
    Tissue Factor and Inflammation
    Clinical Toxicology

    DMSO in Genetics

    Protection from Ionizing Radiation
    DMSO Protection of Single- and Double-Stranded DNA Breaks
    DMSO in Cellular Differentiation
    Cancer Stem Cells and Differentiation

    DMSO in Basic Microbiology

    DMSO in Bacterial Infections
    DMSO and Pathogens
    DMSO in Viral and Fungal Pathology

    DMSO in Clinical Microbiology

    How Bacteria Achieve Antibiotic Resistance
    DMSO in Multidrug-Resistant Tuberculosis

    DMSO in Malignancy

    DMSO and Neoplasia
    Friend Leukemia Cells
    HL-60 Human Cell Line
    Metastatic Liver Disease
    DMSO Combined with Anticancer Agents
    DMSO in Extravasation
    Cancer and Radiation
    Onyx Embolization

    DMSO in Basic Neuroprotection

    Brain Trauma Overview
    Secondary Injury and Ischemic Penumbral Neurons
    DMSO in Experimental Brain Trauma
    Free Radicals in Brain Injury
    Cerebral Hemodynamic Function in Brain Injury
    Tissue Factor
    Cerebral Blood Flow
    DMSO in Brain Concussion
    DMSO Combined with a Glycolytic Intermediate
    DMSO in Experimental Brain Ischemia
    Ethical Considerations for Using Nonhuman Primates in CNS Injuries
    Role of DMSO in Experimental Stroke
    DMSO in Missile Injury to the Brain
    DMSO Compared to Mannitol in Missile Injury
    DMSO in Aging Research
    DMSO in Experimental Dementia
    DMSO in Experimental Spinal Cord Injury
    DMSO as a Solvent

    DMSO in Clinical Neuroprotection

    Overview of Clinical Traumatic Brain Injury
    Head Injury in Children
    Cost and Consequences of Traumatic Brain Injury
    Chronic Traumatic Encephalopathy
    Treating Traumatic Brain Injury
    DMSO in Traumatic Brain Injury
    Optimal DMSO Dose for Traumatic Brain Injury
    Comparing DMSO Doses, Duration of Treatment, and Use as a First- or Second-Line Treatment for Traumatic Brain Injury
    DMSO in Intracranial Aneurysm Hemorrhage
    DMSO Compared to Progesterone for Traumatic Brain Injury
    DMSO + Fructose-1,6-Disphosphate (FDP) for Ischemic Stroke


    Stanley W. Jacob was a professor emeritus of surgery at the Oregon Health Sciences University in Portland. He received his MD from Ohio State University and completed his surgical training at Beth Israel Hospital in Boston. He was a chief resident in surgery at Harvard Surgical Services and an instructor in surgery at Harvard School of Medicine before he was appointed to the faculty at Oregon Health Sciences University. Dr. Jacob discovered the medicinal properties of dimethyl sulfoxide (DMSO). This discovery led to more than 20,000 publications in such areas as pain, inflammation, scleroderma, interstitial cystitis, arthritis, resistant tuberculosis, cancer, cryobiology, free radicals, stroke, and neuroprotection. Dr. Jacob received many honors during his career and also authored a dozen medical textbooks and more than 170 peer-reviewed articles.

    Jack C. de la Torre is an adjunct professor of psychology at the University of Texas in Austin. He began his work on dimethyl sulfoxide (DMSO) in the early 1970s shortly after his appointment as assistant professor in neurosurgery at the University of Chicago. Dr. de la Torre’s research revealed DMSO’s ability to quickly reduce intracranial pressure, restore cerebral blood flow, and stabilize respiration in nonhuman primates sustaining lethal traumatic brain injuries. For the next eight years, he extended his brain trauma findings and showed that intravenous administration of DMSO was effective in treating primary and secondary damage following experimental ischemic stroke and spinal cord trauma. Dr. de la Torre has published more than 180 peer-reviewed research articles and written or edited a dozen medical texts on pathology, neurotransmitters, and Alzheimer’s disease.