Drug Delivery: An Integrated Clinical and Engineering Approach, 1st Edition (Hardback) book cover

Drug Delivery

An Integrated Clinical and Engineering Approach, 1st Edition

Edited by Yitzhak Rosen, Pablo Gurman, Noel Elman

CRC Press

602 pages

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pub: 2017-07-07
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Description

Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.

Reviews

"This book is an excellent approach to the state of art in drug delivery, with the advantage of the clinical view. It is a good starting point to connect very distant spheres of knowledge in a hot spot of advanced molecular controlled release."

—Guillermo R. Castro, Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

"…unique compilation of information in the area of drug delivery, and readers will find useful information not only for their present use but also for furthering science in this area."

—Ambikanandan Misra, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India

Table of Contents

Chapter 1: An Introduction of Key Concepts in Drug Delivery

Steven Kuperberg, M.D., Mahyar Pourriahi, M.D., Jonathan Daich, M.D., Aaron Richler, M.D, Pablo Gurman, M.D., Noel M. Elman, PhD, and Yitzhak Rosen, M.D.

Chapter 2: An Introduction to Pharmacokinetics: From Conventional to Advanced Systemic Drug Delivery Systems

Alan Talevi, Luis Bruno Blanch, and Guillermo R. Castro

Chapter 3: Transporters and Enzymes Targeted Prodrugs for Improved Oral Drug Delivery

Arik Dahan and Shimon Ben-Shabat

Chapter 4: Gastroretentive Delivery: Physicochemical, Biopharmaceutical, Technological and Regulatory Considerations

Vivek K. Pawar, Yuvraj Singh, Mohini Chaurasia, and Manish K. Chourasia

Chapter 5: Invasive vs. Non-Invasive Delivery of Insulin

Sandra Soares, Ana Costa, Pedro Fonte, and Bruno Sarmento

Chapter 6: Artificial Pancreas Drug Delivery

Howard Zisser, MD, Jennifer Lane, Joseph Shivers

Chapter 7: Micro/Nano Devices for Drug Delivery

R. Sheybani and E. Meng

Chapter 8: Microneedle-Mediated Vaccines

Ryan F. Donnelly, Maelíosa T.C. McCrudden, Sharifa Al-Zahrani, and Steven J. Fallows

Chapter 9: Application of Nanoparticle Tracking Analysis in Drug Delivery

Mathew Wright

Chapter 10: Microsponges for Drug Delivery

Rishabh Srivastava

Chapter 11: Chitosan for Advancing Drug Delivery

Sanjay K. Jain and Satish Shilpi

Chapter 12: Gene Delivery by Electroporation

Julie Gehl

Chapter 13: Drug Delivery Systems for Infectious Diseases

Maximiliano L. Cacicedo, Germán A. Islan, Pablo Gurman, and Guillermo R. Castro

Chapter 14: Nanotechnology in Drug Delivery to Chronic Inflammatory Diseases

Mazen El-Hammadi and José L. Arias

Chapter 15: Intrathecal Drug Delivery

Krish Chan

Chapter 16: Cancer Stem Cell Drug Delivery

Masturah Bte Mohd Abdul Rashid, Lissa Nurrul Abdullah, Tan Boon Toh, and Edward Kai-Hua Chow

Chapter 17: Cardiac Drug Delivery

Paula Díaz-Herráez, Simón Pascual-Gil de Gómez, Elisa Garbayo, Teresa Simón-Yarza, Felipe Prósper, and María J. Blanco-Prieto

Chapter 18: Current Developments in Nano-Therapeutics for Airway Diseases

Indrajit Roy, Ridhima Juneja, Komal Sethi, and Neeraj Vij

Chapter 19: Intravitreal Drug Delivery

Omar Saleh M.D., Mark Ihnen, M.D., and Shlomit Schaal M.D., Ph.D

Chapter 20: Drug Delivery in Obstetrics and Gynecology

David Shveiky, M.D., Yael Hants, M.D., and Sarit Helman, M.D.

Chapter 21: Drug Delivery Systems: A Regulatory Perspective

Pablo Gurman, MD, Noel M. Elman, PhD, and Yitzhak Rosen, MD

About the Editors

Dr. Yitzhak Rosen, MD, is a graduate of the Tel Aviv University of Medicine. He is currently working in the Cardiology Department at SUNY Downstate Medical Center. He was previously a visiting research scientist at the Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology. He is also the president and CEO of Superior NanoBioSystems LLC, a biomedical company. He has served in the Israel Defense Forces (IDF) as a medical officer and physician in militarily active areas. He completed a medical internship at the Rabin Medical Center and has worked at the Oncology Institutes of both the Rabin and the Sheba Medical Centers in Israel. He has invented a microfluidic chip platform, funded by the Defense Advanced Research Projects Agency (DARPA), for effecting extremely rapid blood typing and cross-matching for mass casualties in collaboration with the MEMS and Nanotechnology Exchange. In addition, he is the inventor of several medical ultrasound technologies.

Dr. Pablo Gurman received his MD from Buenos Aires University School of Medicine in 2002, where he worked at the Pharmacology Department for 10 years. Dr. Gurman is currently the Chief Medical Officer of GearJump Technologies, a biotechnology company dedicated to develop innovative solutions to public health problems. Prior to this appointment, Dr. Gurman was a research scientist at the Materials Science and Engineering Department at the University of Texas-Dallas, as well as research collaborator at Dr. Elman’s group at the Institute for Soldiers Nanotechnologies at the Massachusetts Institute of Technology (MIT). Dr. Gurman was a visiting scientist at Argonne National Laboratory, where he worked under the artificial retina program. Dr. Gurman’s primary research interests involves micro and nanotechnology for medical diagnostics and therapeutics, controlled release technologies and biomaterials.

Dr. Noel Elman is the CEO and Founder of GearJump Technologies, LLC, a company dedicated to development of biotechnological solutions for public health applications. GearJump has received support from DoD, US Army, US Navy, USDA, as well as Global Grand Challenges via the Bill and Melinda Gates Foundation. Dr. Elman is also an adjunct professor in Technology and Innovation at Buenos Aires Institute of Technology. Dr. Elman worked at Draper Labs, an MIT-affiliated DoD-supported R&D, where he was appointed as Distinguished Member of the Technical Staff. Prior to that appointment, he was a research scientist and principal investigator at the Institute for Soldier Nanotechnologies at MIT, leading a translational research group focused on developing technologies for biotech, biomed and public health applications. In addition, Dr. Elman was appointed an Innovation Fellow at Massachusetts General Hospital. Dr. Elman’s research focus is on rapid translation from idea conceptualization to experimental realization. Dr. Elman received his Bachelor’s and Master’s degrees in Electrical Engineering applied to microsystems from Cornell University, PhD in Physical Electronics applied to lab-on-chip microsystems from the Electrical Engineering Department at Tel-Aviv University and performed postdoctoral studies at MIT, investigating several micro- and nanodevices for therapeutics and diagnostics.

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
MED072000
MEDICAL / Pharmacy