Drug Delivery Systems: 3rd Edition (Hardback) book cover

Drug Delivery Systems

3rd Edition

By Vasant V. Ranade, John B. Cannon

CRC Press

608 pages | 114 B/W Illus.

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pub: 2011-04-25
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Description

Drug delivery technologies represent a vast, vital area of research and development in pharmaceuticals. The demand for innovative drug delivery systems continues to grow, driving a variety of new developments. Drug Delivery Systems, Third Edition provides a comprehensive review of the latest research and development on drug delivery systems.

Coverage includes liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery. Each chapter provides a table of marketed and investigational products with numerous practical examples. The book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives. This third edition contains a chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies.

Written in a straightforward manner, the authors provide a global perspective on current and future advances and market opportunities. Supplying a cogent overview of the field and extensive guidance on where to get more information, it is an essential resource for anyone venturing into this area of drug development.

Table of Contents

Site-Specific Drug Delivery Using Liposomes and Emulsions as Carriers

Introduction

Liposomes in Drug Delivery

The Liposome-Drug Concept

Liposomes as Carriers of Therapeutic Agents

Parenteral Emulsions

Recent Advances and Future Prospects

Concluding Remarks

References

Site-Specific Drug Delivery Utilizing Monoclonal Antibodies

Introduction

Production of Monoclonal Antibodies

Drug–Monoclonal Antibody Conjugates for Drug Targeting

Recent Studies with Monoclonal Antibodies

Conclusion and Basis for Future Trends

References

Role of Polymers in Drug Delivery

Introduction

Currently Available Polymers

Soluble Polymers as Drug Carriers

Biodegradable or Bioerodible Polymers

Mucoadhesive Polymers

Polymers Containing Pendant Bioactive Substituents

Matrix Systems

Heparin-Releasing Polymers

Ionic Polymers

Oligomers

Miscellaneous

Recent Advances

Conclusion

References

Implants in Drug Delivery

Introduction

Insulin Delivery as a Model Implant Pump System

Implants for Contraception

Delivery of Chemotherapeutic Agents Using Implants

Recent Advances in Implants and Related Devices (Excluding Inserts)

Future Prospects

References

Oral Drug Delivery

Controlled-Release Formulations

Introduction

Features of the GI Tract

Targeting of Drugs in the GI Tract

Mathematical Models for Controlled-Release Kinetics

Design and Fabrication of Oral Delivery Systems

Survey of Oral Controlled-Release Products

Recent Advances

Current Development of Oral Drug Delivery Systems

Conclusion

References

Enhancing Oral Bioavailability

Introduction

Increasing Bioavailability of Water-Insoluble Drugs

Increasing Bioavailability of Proteins, Peptides, and Other Drugs with Absorption Problems

Recent Advances and Future Prospects

References

Transdermal Drug Delivery

Introduction

Theoretical Aspects of Transdermal Drug Delivery

Development of the Transdermal Therapeutic System

Examples of Transdermal Applications

Recent Advances and Future Prospects

Conclusion

References

Transmucosal and Ocular Drug Delivery

Introduction: Transmucosal and Ocular Drug Delivery

Pulmonary Drug Delivery

Intranasal Drug Delivery

Buccal and Sublingual Drug Delivery

Rectal, Vaginal, and Other Forms of Transmucosal Drug Delivery

Ocular Drug Delivery

Conclusions and Future Outlook for Transmucosal

and Ocular Drug Delivery

References

Miscellaneous Forms of Drug Delivery

Introduction

Pro-Drugs

Infusion Devices

Insulin Delivery

Recent Advances

Summary

References

Nanoscience and Nanotechnology for Drug Delivery

Introduction

Nanotechnologies

Miscellaneous Applications of Nanomaterials

Nanoparticles and Nanostructures

Nanomedicine and Nanopharmaceuticals

References

Regulatory Considerations for Drug Delivery Systems

Introduction

Current Status of Drug Delivery Technology

Submission of Documents for Manufacture and Quality

References

Drug Delivery Industry and the Global Outlook

Basis for the Recent Trend

References

About the Authors

Vasant V. Ranade is the director of chemical sciences for Academic Pharmaceuticals Inc., in Lake Bluff, Illinois.

John B. Cannon heads his own pharmaceutics and drug delivery consulting company, Targeted Drug Solutions, in Grayslake, Illinois, and serves as a visiting assistant professor at Trinity International University.

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
MED072000
MEDICAL / Pharmacy
SCI013000
SCIENCE / Chemistry / General