Drug Development for Cancer and Diabetes : A Path to 2030 book cover
1st Edition

Drug Development for Cancer and Diabetes
A Path to 2030

ISBN 9781774634936
Published February 28, 2022 by Apple Academic Press
392 Pages 13 Color & 32 B/W Illustrations

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Book Description

Key features include:

  • Details the role of plants for the treatment and management of cancer and diabetes

  • Discusses the role of phytocompounds as ligands for cancer and diabetic targets

  • Reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs

  • Explores the green biosynthesis of nanoparticles and their treatment efficiency

Table of Contents


1. Biomarkers for Screening of Premalignant Lesions and Therapeutic Surveillance

Chukwuebuka Egbuna

2. Kinase Targets in Cancer Drug Discovery

S. Usha

3. Essential Drug Properties and Stages in Anti-Cancer Drug Development

Andrew G. Mtewa, Duncan Sesaazi, Amanjotannu, and Serawit Deyno

4. Plant Constituent as Anti-Cancer Drugs

T. Veni, T. Pushpanathan, and G. Vimala

5. Anticancer Properties of Some Effective Phytochemicals

Murat Alan and Behnaz Aslanipour

6. Therapeutic Aspects of Some Extracts and Purified Cardiac Glycosides Obtained From Nerium oleander L

Behnaz Aslanipour and Murat Alan

7. Challenging Compounds of Some Medicinal Plants Against Cancer

N. Shaista Jabeen, L. Jagapriya, B. Senthilkumar, and K. Devi

8. Medicinal Plants as Therapeutic Agents in the Treatment of Cancer

Jaya Vikaskurhekar

9. Cytotoxic, Apoptosis Inducing Effects and Anti-Cancerous Drug Candidature of Jasmonates

Parth Thakor, Ramalingam B. Subramanian, Sampark S. Thakkar, and Vasudev R. Thakkar

10. Apoptosis Activity of 1,2,-Benzene Dicarboxylic Acid Isolated from Andrographis paniculata on KB, SiHa and IMR Cancer Cell Line

P. Krishnamoorthy and D. Kalaiselvan

11. Anticancer Drug Discovery From the Indian Spice Box

M. V. N. L. Chaitanya, Santhivardhan Chinni, P. Ramalingam, and Y. Padmanabha Reddy

12. Phytochemical Investigation and Evaluation of Anti-Breast Cancer Activity of Chloroform Extract of Tagetes erecta

R. Arul Priya, K. Saravanan, and Chukwaebuka Egbuna

13. Isolation, Identification and In Silico Evaluation of Anticancer Activity of Flavone from Pisum sativum

R. Arul Priya, K. Saravanan, and P. Karuppannan

14. Functional Lead Phytochemicals from the Rutaceae and Zingeiberaceae Plants for Development of Anticancer Drugs

K. Saravanan, B. Umarani, V. Balan, P. Premalatha, and Bir Bahadur

15. In Vitro Anticancer Activity of Biophytum sensitivum on Liver Cancer Lines (HEPG2)

M. P. Santhi, K. Saravanan, and P. Karuppannan

16. Saffron and Its Active Ingredients: A Natural Product with Potent Anticancer Property

Ashutosh Gupta and Abhay K. Pandey


17. Effects of Pterocarpus marsupium in the Management of Type 2 Diabetes Mellitus

Priscilla Suresh

18. Antidiabetic and Antihyperlipidemic Activities of Cyathea nilgiriensis (Holttum) on STZ Induced Diabetic Rats

S. Elavarasi, G. Revathi, K. Saravanan, and Horne Iona Averal

19. Antidiabetic Activity of Drug Loaded Chitosan Nanoparticle

G. Revathi, S. Elavarasi, and K. Saravanan

20. Antidiabetic Activity of Silver Nanoparticles Biosynthesized Using Ventilago maderaspatana Leaf Extract

P. Karuppannan, K. Saravanan, and Horne Iona Averal

21. Hypoglycemic Activity of Biophytum sensitivum Whole Plant Extracts on Alloxan Induced Diabetic Rats

C. Renuka, K. Saravanan, and P. Karuppannan

22. Antidiabetic Activity of Ventilago maderaspatana Leaf Extracts on STZ Induced Diabetic Rats

P. Karuppannan, K. Saravanan, and P. Premalatha

23. Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cyatheia nilgiriensis (Holttum)

S. Elavarasi, G. Revathi, and K. Saravanan

24. Antidiabetic Potentials of Major Indian Spices: A Review

Pratibha, Hema Lohani, S. Zafar Haider, and Nirpendra K. Chauhan

25. Aloe Species: Chemical Composition and Therapeutic Uses in Diabetic Treatment

Amit Kumar Singh, Ramesh Kumar, B. Umarani, and Abhay K. Pandey

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K. Saravanan, PhD, is Associate Dean of Academic Affairs and Assistant Professor of Zoology, Nehru Memorial College, an affiliated institution of Bharathidasan University, Tamilnadu, India. He has been engaged in teaching, research, and writing for over 15 years.

Chukwuebuka Egbuna is a chartered chemist, a chemical analyst, and an academic researcher. He has had many roles at New Divine Favor Pharmaceutical Industry Limited, Nigeria, and Chukwuemeka Odumegwu Ojukwu University, Nigeria. He has published research articles on phytochemistry as well as the 3-volume book Phytochemistry with AAP.

Horne Iona Averal, PhD, is Associate Professor at Holy Cross College, Trichy, India. She has received many awards and honors and has been engaged with many academic roles at several colleges and universities. Dr. Averal has published four nucleotide sequences in the NCBI-GENBANK.

S. Kannan, PhD, is a specialist in cancer biology and nanomedicine. He has held many roles at national and international academic and scientific bodies and has published a large number of research articles and books in his field.

S. Elavarasi, PhD, is Assistant Professor at Holy Cross College, an affiliated institution of Bharathidasan University, Tamilnadu, India. She has been engaged in teaching and research for more than eight years. She has published research articles, book chapters, and books.

Bir Bahadur, PhD, was formerly Professor, Chairman, and Head of the Department, as well as Dean of the Faculty of Science at Kakatiya University in Warangal, India. A prolific writer and editor, he received many awards and honors during his long career, including being named as an Eminent Botanist of India.


“This book extrapolates the recent advancements, emerging trends, and novel innovations and speculates about the future perspective in the discovery of drugs for the treatment of cancer and diabetes. As a complete package for the readers, this book provides a valuable window on the revolutionary sector of drug discovery. Part I and Part II of the book together provides comprehensive content to understand the theoretical aspect as well as practical advances and research discoveries. The novel approach of depicting the role of plants and the potential of phytochemi¬cals as antidiabetic and anticancer drugs is a key feature.”
—From the Foreword by Dr. P. Padmanabhan, Deputy Director, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore