Drug Repositioning: Approaches and Applications for Neurotherapeutics, 1st Edition (Hardback) book cover

Drug Repositioning

Approaches and Applications for Neurotherapeutics, 1st Edition

Edited by Joel Dudley, Laura Berliocchi

CRC Press

313 pages | 30 B/W Illus.

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Hardback: 9781482220834
pub: 2017-06-30
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Description

Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet.

In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development.

For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders.

This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.

Table of Contents

The Rationale and Economics of Drug Repositioning

Repositioning approaches and technologies: from serendipity to systematic and rational strategies

Successful cases of repositioned neurotherapeutics

Current opportunities for drug repositioning in neuronal diseases

Regulatory and Legal Issues

About the Editors

Dr. Joel Dudley is associate professor of genetics and genomic sciences and director of biomedical informatics at Mount Sinai School of Medicine, New York (NY, USA).

Dr. Laura Berliocchi is associate professor of pharmacology at the Department of Health Sciences, Magna Graecia University (Catanzaro, Italy).

About the Series

Frontiers in Neurotherapeutics Series

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI013000
SCIENCE / Chemistry / General
SCI089000
SCIENCE / Life Sciences / Neuroscience