Drug Targeting Technology: Physical Chemical Biological Methods, 1st Edition (Hardback) book cover

Drug Targeting Technology

Physical Chemical Biological Methods, 1st Edition

Edited by Hans Schreier

CRC Press

320 pages

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Hardback: 9780824705800
pub: 2001-08-09
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Description

Demonstrates how substitution of a variety of ligands can render albumin a versatile targeting tool for selective drug accumulation in various cell populations of the liver!

This book discusses physical, chemical, and biological approaches to drug targeting technology, focusing on oral, dispersed system, topical, dermal, transdermal, and inhalation delivery, and the development of original formulations that are matched by innovative device design.

Considers the efforts in biotechnology and molecular biology to produce intelligent drug delivery devices by exploiting biological pathways!

Containing over 1100 references to facilitate further study, Drug Targeting Technology

  • updates recent progress in oral and colonic targeting technology using pH- and enzyme-sensitive coating materials and novel polymer systems

  • shows how the systemic distribution of drugs can be modulated by lipid-based carriers taking alternative routes of transport, particularly lymph flow

  • details soft drugs that are rapidly metabolized to inactive and nontoxic metabolites and removed efficiently from the body

  • includes successful designs of virus-like liposomal delivery systems that offer the advantages of viral carriers

  • supplies examples of how viral delivery systems can be directed to cancer sites

  • and more!

    Suggesting harnessing biological processes as the ultimate approach to the delivery or expression of pharmacologically active agents, Drug Targeting Technology is a top-shelf reference for pharmacists, pharmacologists, and pharmaceutical scientists; analytical, surface, physical, and colloid chemists and biochemists; and upper-level undergraduate and graduate students in these disciplines.

  • Reviews

    "

    …gives the reader the possibility of being much informed.

    "-IASI Polytechnic Magazine

    Table of Contents

    Physical Targeting Approaches

    Enteric Targeting Through Enteric Coating

    Bianca Brögmann and Thomas E. Beckert

    New Experimental Coating Material for Colon-Specific Drug Delivery

    Kurt H. Bauer

    Pharmacokinetic Considerations in the Design of Pulmonary Drug Delivery Systems for Glucocorticoids

    Cary Mobley and Günther Hochhaus

    Lipid-Based Formulations for Oral Administration: Opportunities for Bioavailability Enhancement and Lipoprotein Targeting of Lipophilic Drugs

    Christopher J. H. Porter and William N. Charman

    Topical Application of Drugs: Mechanisms Involved in Chemical Enhancement

    Joke A. Bouwstra, B. A. I. van den Bergh, and M. Suhonen

    Chemical Targeting Approaches

    Drug Targeting by Retrometabolic Design: Soft Drugs and Chemical Delivery Systems

    Nicholas Bodor and Peter Buchwald

    Neoglyco- and Neopeptide Albumins for Cell-Specific Delivery of Drugs to Chronically Diseased Livers

    Leonie Beljaars, Barbro N. Melgert, Dirk K. F. Meijer, Grietje Molema, and Klaas Poelstra

    Biological Targeting Approaches

    Gene Delivery with Artificial Viral Envelopes

    Frank L. Sorgi, Lucie Gagné, and Hans Schreier

    Evolution of Viral Liposomes: Improvements and Applications

    Yasufumi Kaneda, Yoshinaga Saeki, and Ryuichi Morishita

    Targeting of Viral Vectors for Cancer Gene Therapy

    Dirk M. Nettelbeck and Rolf Müller

    About the Series

    Drugs and the Pharmaceutical Sciences

    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    MED071000
    MEDICAL / Pharmacology
    SCI013000
    SCIENCE / Chemistry / General
    SCI013050
    SCIENCE / Chemistry / Physical & Theoretical