1st Edition

Drug Targeting Technology
Physical Chemical Biological Methods




ISBN 9780824705800
Published August 9, 2001 by CRC Press
320 Pages

USD $200.00

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Book Description

Demonstrates how substitution of a variety of ligands can render albumin a versatile targeting tool for selective drug accumulation in various cell populations of the liver!

This book discusses physical, chemical, and biological approaches to drug targeting technology, focusing on oral, dispersed system, topical, dermal, transdermal, and inhalation delivery, and the development of original formulations that are matched by innovative device design.

Considers the efforts in biotechnology and molecular biology to produce intelligent drug delivery devices by exploiting biological pathways!

Containing over 1100 references to facilitate further study, Drug Targeting Technology

  • updates recent progress in oral and colonic targeting technology using pH- and enzyme-sensitive coating materials and novel polymer systems
  • shows how the systemic distribution of drugs can be modulated by lipid-based carriers taking alternative routes of transport, particularly lymph flow
  • details soft drugs that are rapidly metabolized to inactive and nontoxic metabolites and removed efficiently from the body
  • includes successful designs of virus-like liposomal delivery systems that offer the advantages of viral carriers
  • supplies examples of how viral delivery systems can be directed to cancer sites
  • and more!
    Suggesting harnessing biological processes as the ultimate approach to the delivery or expression of pharmacologically active agents, Drug Targeting Technology is a top-shelf reference for pharmacists, pharmacologists, and pharmaceutical scientists; analytical, surface, physical, and colloid chemists and biochemists; and upper-level undergraduate and graduate students in these disciplines.
  • Table of Contents

    Physical Targeting Approaches

    Enteric Targeting Through Enteric Coating
    Bianca Brögmann and Thomas E. Beckert
    New Experimental Coating Material for Colon-Specific Drug Delivery
    Kurt H. Bauer
    Pharmacokinetic Considerations in the Design of Pulmonary Drug Delivery Systems for Glucocorticoids
    Cary Mobley and Günther Hochhaus
    Lipid-Based Formulations for Oral Administration: Opportunities for Bioavailability Enhancement and Lipoprotein Targeting of Lipophilic Drugs
    Christopher J. H. Porter and William N. Charman
    Topical Application of Drugs: Mechanisms Involved in Chemical Enhancement
    Joke A. Bouwstra, B. A. I. van den Bergh, and M. Suhonen

    Chemical Targeting Approaches

    Drug Targeting by Retrometabolic Design: Soft Drugs and Chemical Delivery Systems
    Nicholas Bodor and Peter Buchwald
    Neoglyco- and Neopeptide Albumins for Cell-Specific Delivery of Drugs to Chronically Diseased Livers
    Leonie Beljaars, Barbro N. Melgert, Dirk K. F. Meijer, Grietje Molema, and Klaas Poelstra

    Biological Targeting Approaches

    Gene Delivery with Artificial Viral Envelopes
    Frank L. Sorgi, Lucie Gagné, and Hans Schreier
    Evolution of Viral Liposomes: Improvements and Applications
    Yasufumi Kaneda, Yoshinaga Saeki, and Ryuichi Morishita
    Targeting of Viral Vectors for Cancer Gene Therapy
    Dirk M. Nettelbeck and Rolf Müller

    ...
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    Reviews

    "
    …gives the reader the possibility of being much informed.
    "-IASI Polytechnic Magazine