Stroke is the third leading cause of death in the USA and UK. It is a major cause of disability among adults and is a significant factor in dementia in later life and its incidence is on the rise. This book discusses specific medications that target the blood and vasculature and how these treatments can be used to complement other therapeutic measures, such as carotid endarterectomy. It covers the pharmacological methods used to address the risk factors in stroke, the major drug discoveries of recent years--antiaggregant, antithrombotic, and anticoagulant therapies--and also long established therapies such as aspirin and warfarin. With contributions by internationally recognized experts, this is a unique single source of information on current pharmacological prevention of stroke.
1. Stroke Prevention in 2000 J. Easton 2. Primary vs. Secondary Stroke Prevention P. Gorelick 3. Aspirin P. De Moerloose 4. Ticlopidine and Clopidogrel M. Paciaroni 5. Other Anti-platelet Agents A. Culebras 6. Dipyridamole H. Diener 7. New Antiplatelet Agents B. Weksler 8. Clinical Use of Antiplatelet Agents for Stroke Prevention G. Donnan 9. Antithrombotic Therapy Before and After Carotid Endarterectomy H. Barnett 10. Anticoagulants T. Moulin 11. Early Prevention of Stroke Recurrence M. Brown 12. Lipid Lowering Agents and Stroke Risk P. Amarenco 13. Stroke Prevention With Blood Pressure Control P. Bath 14. Antioxidants, Vitamins D. Spence 15. Estrogen Replacement L. Brass 16. Healthcare Issues, Benefits and Costs G. Hankey Gorelick, Centre for Stroke Research, USA, Babette Weksler, Cornell University, USA, Geoffrey Donnan, National Stroke Research Institute, Australia, H. Barnett, Robarts Research Institute, Canada, Martin Brown, University of London, UK, Pierre Amarenco, Hospital Lariboisere, France, Phillipe Bath, Nottingham City Hospital, UK, J. David Spence, Robarts Research Institute, Canada, Graeme Hankey, Royal Perth Hospital, Australia, H. Diener, Neurologische Uniklinik, Germany, Lawrence Brass, Yale University School of Medicine, USA, Thierry Moulin, Hospital Regional de Bescancon, Maurizio Paciaroni, University of Perugia, Italy, Antonio Culebras, VA Medical Centre, USA, Phillipe de Moerloose, HUG, Geneva.