This book is devoted to the effects of food and of nutrient intake on the disposition of foreign compounds, and discusses effects of drugs on nutrition. It is intended for nutritionists and clinical investigators concerned with interpretation of aberrant effects of therapeutic drugs.
Part I: Nutritional Effects on Drug and Foreign Compound Activities 1. Methodologies Used for the Determination of Chemical Body Burdens 2. Plasma Binding, Distribution, and Elimination 3. Dietary Lipids and Foreign Compound (Carcinogen) Metabolism 4. Retinoids and Drug–Metabolizing Enzymes 5. Availability of Cosubstrates as a Rate–Limiting Factor 6. Glutathione Conjugation Systems and Drug Disposition 7. Ascorbic Acid in Drug Metabolism Part II: Effects of Drugs on Nutrition 8. Drug—Nutrient Interactions in Teratogenesis 9. Human Milk: A Portal of Drugs from Mother to Infant 10. Drugs, Appetite, and Body Weight 11. Anticonvulsant-Drug-Indueed Mineral Disorders 12. Vitamin K and Vitamin K Antagonists 13. Drug-Induced Maldigestion and Malabsorption 14. Toxic Pancreatitis 15. Risk Factors in Drug-Induced Nutritional Deficiencies