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Understanding the nature and role of endothelium-derived hyperpolarizing factor appears to be crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion and other vascular disorders.
EDHF 2002 contains the proceedings of the Fourth International Symposium on endothelium-dependent hyperpolarizations and will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.
Table of Contents
1. Potassium Channels and Member Potential in Vascular Endothelial and Smooth Muscle Cells 2. Possible Contribution to CLCA1 to Calcium-Activated Chloride Channels in Murine Smooth Muscle Cells 3. Trafficking and Transduction Functions of the NA Pump in Vascular Smooth Muscle Cells 4. Isoforms of NA, K-Atpase 5. Calcium Sparks and Membrane Potential 6. Proteinase-Activated Receptor-2: Release of an Endothelium-Derived Hyperpolarizing Factor Distinct from that Released by Acetylcholine 7. Mechanical Stimulation Increases the Activity and Expression of Cytochrome P450 2C in Porcine Coronary Artery Endothelial Cells 8. Important Role of Hydrogen Peroxide as an Endothelium-Derived Hyperpolarizing Factor in Animals and Humans 9. Altered Calcium Dynamics do not Account for the Attenuation of EDHF-Mediated Dilatations in the Middle Cerebral Artery of Female Rats 10. Connexin-Mimetic Peptides: Influence of Nitric Oxide Synthase and Cyclooxygenase-Independent Renal Vasodilatation, Basal Renal Blood Flow and Blood Pressure in the Rat 11. Urocortin-Induced Relaxations of the Rat Coronary Artery 12. Nitric Oxide is the Only EDHF Released by the Endothelium in Lymphatic Vessels of the Guinea-Pig Mesentery 13. Role of EDHF in Vascular Tone in vivo 15. Improvement of Age-Related Impairment of Endothelium-Derived Hyperpolarization by Renin-Angiotensin System Blockade 16. Characterization of Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation of Small Mesenteric Arteries from Diabetic (DB/DB -/-) Mice 17. Endothelium-Dependant Responses in Small Arteries Isolated from Normal and Pre-Eclamptic Pregnant Women 18. Free Radical Species and Endothelium Dysfunction During Deoxycorticosterone-Salt Induced Hypertension 19. EDHF Involvement in Skin Pressure-Induced Vasodilation 20. N-Acetylcysteine and Immobilization Stress Attenuate the Dysregulation of Endthelium-Dependent Coronary Vascular Tone Induced by Acute Hemorrhage 21. Red Wine Polyphenolic Compounds Induce EDHF-Mediated Relaxation and Hyperpolarization in the Porcine Coronary Artery: Involvement of Redox-Sensitive Mechanisms 22. Estrogen Substitution Restores the Basal Influence of Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor on Vascular Tone in Isolated Mesenteric Arteries from Ovariectomized Rats 23. Ascorbate Inhibits EDHF in the Bovine Eye but not in the Porcine Coronary artery 24. Gabexate Mesilate Inhibits Endothelium-Dependent Relaxation, But Causes Endothelium-Independent Relaxation of Rat Blood Vessels 25. Mechanisms Underlying Basal Vascular Tone in the Guinea-Pig Mesenteric Aterioles 26. Endothelium-Dependent Depolarization and its Implications for Endothelium-Derived Hyperpolarizing Factor 27. Role of Gap Junctions in EDHF-Mediated Relaxation Response in Human Subcutaneous Resistance Arteries 28. Permissive Role of Camp in the Mediation of Relaxations Initiated by Endothelial Hyperpolarization 29. Myoendethelial Gap Junctions