Electrochemical DNA Biosensors: 1st Edition (Hardback) book cover

Electrochemical DNA Biosensors

1st Edition

Edited by Mehmet Sengun Ozsoz

Jenny Stanford Publishing

400 pages | 35 Color Illus. | 130 B/W Illus.

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Hardback: 9789814241779
pub: 2012-04-23
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Description

This book focuses on the basic electrochemical applications of DNA in various areas, from basic principles to the most recent discoveries. The book comprises theoretical and experimental analysis of various properties of nucleic acids, research methods, and some promising applications. The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticle and nanotubes; nanomaterial-based electrochemical DNA detection; electrochemical detection of microorganism-based DNA biosensors; gold nanoparticle-based electrochemical DNA biosensors; electrochemical detection of the aptamer-target interaction; nanoparticle-induced catalysis for DNA biosensing; basic terms regarding electrochemical DNA (nucleic acids) biosensors; screen-printed electrodes for electrochemical DNA detection; application of field-effect transistors to label free electrical DNA biosensor arrays; and electrochemical detection of nucleic acids using branched DNA amplifiers.

Reviews

"The marriage of natural and synthetic nanotechnology in electrochemical DNA sensors is a fascinating object of research. The reader gets an easy access to the complex matter by the well-written introductory chapter. This volume builds a bridge from molecular biology to the applications in medical diagnostics and microbiology."

—Prof. Frieder Scheller - Universität Potsdam, Germany

"This book is a very welcome contribution to the literature of electrochemical DNA biosensors. It offers extremely useful insights into this exciting and important field."

—Dr. Joseph Wang - University of California, San Diego, USA

Table of Contents

Preface

Terminology Related to Electrochemical DNA-Based Biosensors Jan Labuda

Introduction

Detection Features of DNA-Based Biosensors

Detection of Specific DNA Interactions

Conclusions

Electrochemical Aptamer-Based Biosensors S. Centi, S. Tombelli, and M. Mascini

Introduction

Electrochemical Detection Strategies Based on Labeling

Electrochemical Aptasensors Based on a Sandwich Assay

Electrochemical Aptasensors Based on a Competitive Assay

Electrochemical Aptasensors Based on a Direct Assay 37

Electrochemical Metal Nanoparticle-Labeled Aptasensors 392.7 Electrochemical Aptasensors Based on Noncovalent Redox Species Label

Electrochemical Aptasensors Based on the Aptamer Conformational Changes

Electrochemical Aptasensors Based on Target-Induced Aptamer Displacement

Conclusions

Carbon-Polymer Bio-Nano-Composite Electrodes for Electrochemical Genosensing Mar´ıa Isabel Pividori and Salvador Alegret

Introduction

Composites Materials: Main Features and Classification

Carbon Composites

Electrochemical Genosensing Based on Graphite-Epoxy Composite

Final Remarks

Gold Nanoparticle-Based Electrochemical DNA Biosensors Mar´ıa Pedrero, Paloma Y´a ˜ nez-Sede ˜ no,

and Jos´e M. Pingarr´on

Introduction

Configurations Used for DNA Immobilization

Signal Transduction and Amplification Strategies

Conclusions and Outlook

Nanoparticle-Induced Catalysis for Electrochemical DNA Biosensors Marisa Maltez-da Costa, Alfredo de la Escosura-Mu˜ niz, and Arben Merkoc¸i

Introduction

Catalysis Induced by Gold Nanoparticles 1455.2.1 Electrocatalytic Activity of Gold Nanoparticle Labels on Silver Deposition

Catalysis Induced by Platinum and Palladium Nanoparticles

Catalysis Induced by Other Nanoparticles

Conclusions

Application of Field-Effect Transistors to Label-Free Electrical DNA Biosensor Arrays Peng Li, Piero Migliorato, and Pedro Estrela

Introduction

Field-Effect Transistors

Field-Effect DNA Sensing

Electrochemical Impedance Spectroscopy

Application of FETs on Biosensor Arrays

Conclusions

Electrochemical Detection of Basepair Mismatches in DNA Films Piotr Michal Diakowski, Mohtashim Shamsi,

and Heinz-Bernhard Kraatz

Introduction

Surface Immobilization

Detection Strategies

Conclusion

Electrochemical Detection of DNA Hybridization: Use of Latex to Construct Metal-Nanoparticle Labels Mithran Somasundrum andWerasak Surareungchai

Introduction

Synthesis of Metal Nanoparticles

Use of Metal Nanoparticles as Electrochemical Labels

Voltammetric Detection of Metal-Nanoparticle Labels

Latex as a Label Support

DNA Measurement

Areas for Further Research

Screen-Printed Electrodes for Electrochemical DNA Detection Graciela Mart´ınez-Paredes, Mar´ıa Bego ˜ na Gonz´ alez-Garc´ıa, and Agust´ın Costa-Garc´ıa

Introduction

Fabrication of Screen-Printed Electrodes

Genosensors on Screen-Printed Electrodes

Applications

Conclusion

Synthetic Polymers for Electrochemical DNA Biosensors Adriana Ferancov ´a and Katar´ına Ben´ıkov ´a

Introduction

Modification of Electrode Surface with Polymers

Polymer-Assisted DNA Immobilization

Application of Synthetic Polymers in DNA Biosensors

Conclusions

Electrochemical Transducer for Oligonucleotide Biosensor Based on the Elimination and Adsorptive Transfer Techniques Libuse Trnkova, Frantisek Jelen, and Mehmet Ozsoz

Introduction

Theoretical Fundamentals of Elimination Voltammetry with Linear Scan (EVLS)

EVLS Increasing the Transducer Potential Range

EVLS in Connection with Adsorptive Stripping Technique

EVLS of Nucleobases and Oligonucleotides in the Presence of Copper Ions

Conclusions

Electrochemical DNA Biosensors for Detection of Compound-DNA Interactions D. Ozkan-Ariksoysal, P. Kara, and M. Ozsoz

Introduction

The Structure of DNA

Natural Electronalytical Characterictics of DNA

Types of DNA Immobilization Methodologies onto Sensor Surfaces

DNA-Compound Interactions

Calculations About Compound-DNA Interactions

Conclusions

Electrochemical Nucleic Acid Biosensors Based on Hybridization Detection for Clinical Analysis P. Kara, D. Ariksoysal, and M. Ozsoz

Introduction

Biosensors

Electrochemical Nucleic Acid Biosensors

Conclusion

Nanomaterial-Based Electrochemical DNA Detection Ronen Polsky, Jason C. Harper, and Susan M. Brozik

Introduction

Nanoparticle-Based Electrochemical DNA Detection

Nanowires, Nanorods, and Nanofibers

DNA Detection Using Carbon Nanotubes

Conclusion

Electrochemical Genosensor Assay for the Detection of Bacteria on Screen-Printed Chips Chan Yean Yean, Lee Su Yin, and Manickam Ravichandran

Introduction

Methods for the Detection and Identification of Microorganism Utilizing Enzyme-Based Genosensors on Screen-Printed Chips

Advantages of the Enzyme-Based Electrochemical Genosensors in Detecting Bacteria on Screen-Printed Carbon Chips

Conclusions

Introduction to Molecular Biology Related to Electrochemical DNA-Based Biosensors Yalcin Erzurumlu and Petek Ballar

Introduction

Nucleic Acids

Deoxyribonucleic Acid

DNA in Electrochemical DNA-Based Biosensors

Nucleic Acid Variants Used in Electrochemical DNA-Based Biosensors

Index

Subject Categories

BISAC Subject Codes/Headings:
SCI013060
SCIENCE / Chemistry / Industrial & Technical
TEC021000
TECHNOLOGY & ENGINEERING / Material Science
TEC064000
TECHNOLOGY & ENGINEERING / Sensors