1st Edition

Electrochemical DNA Biosensors

Edited By Mehmet Sengun Ozsoz Copyright 2012
    566 Pages 35 Color & 130 B/W Illustrations
    by Jenny Stanford Publishing

    Continue Shopping

    This book focuses on the basic electrochemical applications of DNA in various areas, from basic principles to the most recent discoveries. The book comprises theoretical and experimental analysis of various properties of nucleic acids, research methods, and some promising applications. The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticle and nanotube; nanomaterial-based electrochemical DNA detection; electrochemical detection of microorganism-based DNA biosensor; gold nanoparticle-based electrochemical DNA biosensors; electrochemical detection of the aptamer-target interaction: nanoparticle-induced catalysis for DNA biosensing; basic terms regarding electrochemical DNA (nucleic acids) biosensors; screen-printed electrodes for electrochemical DNA detection: application of field-effect transistors to label free electrical DNA biosensor arrays; and electrochemical detection of nucleic acids using branched DNA amplifiers.

    Terminology Related to Electrochemical DNA-Based Biosensors Jan Labuda
    Detection Features of DNA-Based Biosensors
    Detection of Specific DNA Interactions
    Electrochemical Aptamer-Based Biosensors S. Centi, S. Tombelli, and M. Mascini
    Electrochemical Detection Strategies Based on Labeling
    Electrochemical Aptasensors Based on a Sandwich Assay
    Electrochemical Aptasensors Based on a Competitive Assay
    Electrochemical Aptasensors Based on a Direct Assay 37
    Electrochemical Metal Nanoparticle-Labeled Aptasensors 392.7 Electrochemical Aptasensors Based on Noncovalent Redox Species Label
    Electrochemical Aptasensors Based on the Aptamer Conformational Changes
    Electrochemical Aptasensors Based on Target-Induced Aptamer Displacement
    Carbon-Polymer Bio-Nano-Composite Electrodes for Electrochemical Genosensing Mar´ıa Isabel Pividori and Salvador Alegret
    Composites Materials: Main Features and Classification
    Carbon Composites
    Electrochemical Genosensing Based on Graphite-Epoxy Composite
    Final Remarks
    Gold Nanoparticle-Based Electrochemical DNA Biosensors Mar´ıa Pedrero, Paloma Y´a ˜ nez-Sede ˜ no,
    and Jos´e M. Pingarr´on
    Configurations Used for DNA Immobilization
    Signal Transduction and Amplification Strategies
    Conclusions and Outlook
    Nanoparticle-Induced Catalysis for Electrochemical DNA Biosensors Marisa Maltez-da Costa, Alfredo de la Escosura-Mu˜ niz, and Arben Merkoc¸i
    Catalysis Induced by Gold Nanoparticles 1455.2.1 Electrocatalytic Activity of Gold Nanoparticle Labels on Silver Deposition
    Catalysis Induced by Platinum and Palladium Nanoparticles
    Catalysis Induced by Other Nanoparticles
    Application of Field-Effect Transistors to Label-Free Electrical DNA Biosensor Arrays Peng Li, Piero Migliorato, and Pedro Estrela
    Field-Effect Transistors
    Field-Effect DNA Sensing
    Electrochemical Impedance Spectroscopy
    Application of FETs on Biosensor Arrays
    Electrochemical Detection of Basepair Mismatches in DNA Films Piotr Michal Diakowski, Mohtashim Shamsi,
    and Heinz-Bernhard Kraatz
    Surface Immobilization
    Detection Strategies
    Electrochemical Detection of DNA Hybridization: Use of Latex to Construct Metal-Nanoparticle Labels Mithran Somasundrum andWerasak Surareungchai
    Synthesis of Metal Nanoparticles
    Use of Metal Nanoparticles as Electrochemical Labels
    Voltammetric Detection of Metal-Nanoparticle Labels
    Latex as a Label Support
    DNA Measurement
    Areas for Further Research
    Screen-Printed Electrodes for Electrochemical DNA Detection Graciela Mart´ınez-Paredes, Mar´ıa Bego ˜ na Gonz´ alez-Garc´ıa, and Agust´ın Costa-Garc´ıa
    Fabrication of Screen-Printed Electrodes
    Genosensors on Screen-Printed Electrodes
    Synthetic Polymers for Electrochemical DNA Biosensors Adriana Ferancov ´a and Katar´ına Ben´ıkov ´a
    Modification of Electrode Surface with Polymers
    Polymer-Assisted DNA Immobilization
    Application of Synthetic Polymers in DNA Biosensors
    Electrochemical Transducer for Oligonucleotide Biosensor Based on the Elimination and Adsorptive Transfer Techniques Libuse Trnkova, Frantisek Jelen, and Mehmet Ozsoz
    Theoretical Fundamentals of Elimination Voltammetry with Linear Scan (EVLS)
    EVLS Increasing the Transducer Potential Range
    EVLS in Connection with Adsorptive Stripping Technique
    EVLS of Nucleobases and Oligonucleotides in the Presence of Copper Ions
    Electrochemical DNA Biosensors for Detection of Compound-DNA Interactions D. Ozkan-Ariksoysal, P. Kara, and M. Ozsoz
    The Structure of DNA
    Natural Electronalytical Characterictics of DNA
    Types of DNA Immobilization Methodologies onto Sensor Surfaces
    DNA-Compound Interactions
    Calculations About Compound-DNA Interactions
    Electrochemical Nucleic Acid Biosensors Based on Hybridization Detection for Clinical Analysis P. Kara, D. Ariksoysal, and M. Ozsoz
    Electrochemical Nucleic Acid Biosensors
    Nanomaterial-Based Electrochemical DNA Detection Ronen Polsky, Jason C. Harper, and Susan M. Brozik
    Nanoparticle-Based Electrochemical DNA Detection
    Nanowires, Nanorods, and Nanofibers
    DNA Detection Using Carbon Nanotubes
    Electrochemical Genosensor Assay for the Detection of Bacteria on Screen-Printed Chips Chan Yean Yean, Lee Su Yin, and Manickam Ravichandran
    Methods for the Detection and Identification of Microorganism Utilizing Enzyme-Based Genosensors on Screen-Printed Chips
    Advantages of the Enzyme-Based Electrochemical Genosensors in Detecting Bacteria on Screen-Printed Carbon Chips
    Introduction to Molecular Biology Related to Electrochemical DNA-Based Biosensors Yalcin Erzurumlu and Petek Ballar
    Nucleic Acids
    Deoxyribonucleic Acid
    DNA in Electrochemical DNA-Based Biosensors
    Nucleic Acid Variants Used in Electrochemical DNA-Based Biosensors

    "The marriage of natural and synthetic nanotechnology in electrochemical DNA sensors is a fascinating object of research. The reader gets an easy access to the complex matter by the well-written introductory chapter. This volume builds a bridge from molecular biology to the applications in medical diagnostics and microbiology."
    —Prof. Frieder Scheller - Universität Potsdam, Germany

    "This book is a very welcome contribution to the literature of electrochemical DNA biosensors. It offers extremely useful insights into this exciting and important field."
    —Dr. Joseph Wang - University of California, San Diego, USA