Electrochemical DNA Biosensors  book cover
1st Edition

Electrochemical DNA Biosensors

ISBN 9789814241779
Published April 23, 2012 by Jenny Stanford Publishing
566 Pages 35 Color & 130 B/W Illustrations

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Book Description

This book focuses on the basic electrochemical applications of DNA in various areas, from basic principles to the most recent discoveries. The book comprises theoretical and experimental analysis of various properties of nucleic acids, research methods, and some promising applications. The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticle and nanotubes; nanomaterial-based electrochemical DNA detection; electrochemical detection of microorganism-based DNA biosensors; gold nanoparticle-based electrochemical DNA biosensors; electrochemical detection of the aptamer-target interaction; nanoparticle-induced catalysis for DNA biosensing; basic terms regarding electrochemical DNA (nucleic acids) biosensors; screen-printed electrodes for electrochemical DNA detection; application of field-effect transistors to label free electrical DNA biosensor arrays; and electrochemical detection of nucleic acids using branched DNA amplifiers.

Table of Contents

Terminology Related to Electrochemical DNA-Based Biosensors Jan Labuda
Detection Features of DNA-Based Biosensors
Detection of Specific DNA Interactions
Electrochemical Aptamer-Based Biosensors S. Centi, S. Tombelli, and M. Mascini
Electrochemical Detection Strategies Based on Labeling
Electrochemical Aptasensors Based on a Sandwich Assay
Electrochemical Aptasensors Based on a Competitive Assay
Electrochemical Aptasensors Based on a Direct Assay 37
Electrochemical Metal Nanoparticle-Labeled Aptasensors 392.7 Electrochemical Aptasensors Based on Noncovalent Redox Species Label
Electrochemical Aptasensors Based on the Aptamer Conformational Changes
Electrochemical Aptasensors Based on Target-Induced Aptamer Displacement
Carbon-Polymer Bio-Nano-Composite Electrodes for Electrochemical Genosensing Mar´ıa Isabel Pividori and Salvador Alegret
Composites Materials: Main Features and Classification
Carbon Composites
Electrochemical Genosensing Based on Graphite-Epoxy Composite
Final Remarks
Gold Nanoparticle-Based Electrochemical DNA Biosensors Mar´ıa Pedrero, Paloma Y´a ˜ nez-Sede ˜ no,
and Jos´e M. Pingarr´on
Configurations Used for DNA Immobilization
Signal Transduction and Amplification Strategies
Conclusions and Outlook
Nanoparticle-Induced Catalysis for Electrochemical DNA Biosensors Marisa Maltez-da Costa, Alfredo de la Escosura-Mu˜ niz, and Arben Merkoc¸i
Catalysis Induced by Gold Nanoparticles 1455.2.1 Electrocatalytic Activity of Gold Nanoparticle Labels on Silver Deposition
Catalysis Induced by Platinum and Palladium Nanoparticles
Catalysis Induced by Other Nanoparticles
Application of Field-Effect Transistors to Label-Free Electrical DNA Biosensor Arrays Peng Li, Piero Migliorato, and Pedro Estrela
Field-Effect Transistors
Field-Effect DNA Sensing
Electrochemical Impedance Spectroscopy
Application of FETs on Biosensor Arrays
Electrochemical Detection of Basepair Mismatches in DNA Films Piotr Michal Diakowski, Mohtashim Shamsi,
and Heinz-Bernhard Kraatz
Surface Immobilization
Detection Strategies
Electrochemical Detection of DNA Hybridization: Use of Latex to Construct Metal-Nanoparticle Labels Mithran Somasundrum andWerasak Surareungchai
Synthesis of Metal Nanoparticles
Use of Metal Nanoparticles as Electrochemical Labels
Voltammetric Detection of Metal-Nanoparticle Labels
Latex as a Label Support
DNA Measurement
Areas for Further Research
Screen-Printed Electrodes for Electrochemical DNA Detection Graciela Mart´ınez-Paredes, Mar´ıa Bego ˜ na Gonz´ alez-Garc´ıa, and Agust´ın Costa-Garc´ıa
Fabrication of Screen-Printed Electrodes
Genosensors on Screen-Printed Electrodes
Synthetic Polymers for Electrochemical DNA Biosensors Adriana Ferancov ´a and Katar´ına Ben´ıkov ´a
Modification of Electrode Surface with Polymers
Polymer-Assisted DNA Immobilization
Application of Synthetic Polymers in DNA Biosensors
Electrochemical Transducer for Oligonucleotide Biosensor Based on the Elimination and Adsorptive Transfer Techniques Libuse Trnkova, Frantisek Jelen, and Mehmet Ozsoz
Theoretical Fundamentals of Elimination Voltammetry with Linear Scan (EVLS)
EVLS Increasing the Transducer Potential Range
EVLS in Connection with Adsorptive Stripping Technique
EVLS of Nucleobases and Oligonucleotides in the Presence of Copper Ions
Electrochemical DNA Biosensors for Detection of Compound-DNA Interactions D. Ozkan-Ariksoysal, P. Kara, and M. Ozsoz
The Structure of DNA
Natural Electronalytical Characterictics of DNA
Types of DNA Immobilization Methodologies onto Sensor Surfaces
DNA-Compound Interactions
Calculations About Compound-DNA Interactions
Electrochemical Nucleic Acid Biosensors Based on Hybridization Detection for Clinical Analysis P. Kara, D. Ariksoysal, and M. Ozsoz
Electrochemical Nucleic Acid Biosensors
Nanomaterial-Based Electrochemical DNA Detection Ronen Polsky, Jason C. Harper, and Susan M. Brozik
Nanoparticle-Based Electrochemical DNA Detection
Nanowires, Nanorods, and Nanofibers
DNA Detection Using Carbon Nanotubes
Electrochemical Genosensor Assay for the Detection of Bacteria on Screen-Printed Chips Chan Yean Yean, Lee Su Yin, and Manickam Ravichandran
Methods for the Detection and Identification of Microorganism Utilizing Enzyme-Based Genosensors on Screen-Printed Chips
Advantages of the Enzyme-Based Electrochemical Genosensors in Detecting Bacteria on Screen-Printed Carbon Chips
Introduction to Molecular Biology Related to Electrochemical DNA-Based Biosensors Yalcin Erzurumlu and Petek Ballar
Nucleic Acids
Deoxyribonucleic Acid
DNA in Electrochemical DNA-Based Biosensors
Nucleic Acid Variants Used in Electrochemical DNA-Based Biosensors

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"The marriage of natural and synthetic nanotechnology in electrochemical DNA sensors is a fascinating object of research. The reader gets an easy access to the complex matter by the well-written introductory chapter. This volume builds a bridge from molecular biology to the applications in medical diagnostics and microbiology."
—Prof. Frieder Scheller - Universität Potsdam, Germany

"This book is a very welcome contribution to the literature of electrochemical DNA biosensors. It offers extremely useful insights into this exciting and important field."
—Dr. Joseph Wang - University of California, San Diego, USA