Elongate Mineral Particles Characterization, Classification, and Risk Analysis

Introduction. 1. Definition of a mineral fiber: How the science and regulations approach asbestiform fibers and non-asbestiform fragments. 2. Measurements of EMPs: Analytical approaches and the development of the dimensional database. 3. Fractional characteristics of elongate mineral particles and their relationship with cancer potency factors. 4. Mesothelial toxicity of elongate mineral particles: The mode of action and quantitative interpretation. 5. Cell responses to Elongated Mineral Fibers: Multiple roles of shape and dimension. 6. Elongate mineral particles in tissue: physical and mineralogical characteristics of retained EMPs. 7. Mechanical properties as a predictor of mesotheliomagenicity. 8. Characteristics of elongate mineral particles relevant for carcinogenic risk assessment. 9. Classification of elongate mineral particles by their habit. 10. Toxicological assessment for a mixture of fibrous dusts: The case of the Boulder City Bypass Project. 11. The soil contamination by asbestos in Armley, Leeds (U.K.): Dimensional characteristics as a “footprint” of exposure. 12. Peritoneal mesothelioma hazard rate in rats as a function of mineralogical parameters: Revisiting the results of the experimental study. 13. Asbestos terminology: How to combine mineralogical, toxicological, and analytical information for the purpose of standardization. 14. Regulatory priorities for elongate mineral particles in the new era. 

Biography

Dr. Andrey Korchevskiy, PhD, DABT, CIH, is a diplomate of the American Board of Toxicology (DABT) and a certified industrial hygienist (CIH), USA. He is the Director of Research and Development at Chemistry & Industrial Hygiene, Inc. (C&IH) (Lakewood, Colorado). Dr. Korchevskiy holds separate PhD degrees in Applied Mathematics and Biology. He has over 150 publications in various peer-reviewed journals and was a leading editor and author of a monograph on risk assessment for asbestos and other fibrous minerals. He has also published works in the area of the theory of numbers, his favorite area of mathematics.

Dr. Ann Wylie, PhD, holds a BA from Wellesley College and a PhD from Columbia University, USA. She joined the faculty at the University of Maryland in 1972, where she has taught courses in optical mineralogy, mineralogy, economic geology, X-ray diffraction, and ore microscopy. She currently holds the rank of Emerita Professor and Distinguished Scholar Teacher in the Department of Geology. She is an elected fellow of the Geological Society of America and the American Association for the Advancement of Science. She is also a senior scientific advisor for Chemistry & Industrial Hygiene, Inc. Her work has been published in both the mineralogical and toxicological literature. She has served as a consultant to both government and industry.

‘Elongate Mineral Particles: Characterization, Classification, and Risk Analysis is the definitive text that our profession has needed for decades. It will fundamentally shape our understanding and approach to one of the most critical challenges in occupational and environmental health.

 

This is not just an academic exercise but also a foundation of rational risk assessment and public policy. It is certain to become the standard reference in the field."

 

• Shu-Chun Su, Ph.D., Independent Researcher

 

‘This outstanding text is a must read for anyone who is interested in the potential for elongate mineral particles in disease causation. The authors, who are well-recognized experts in the field, provide a thorough and mathematically rigorous analysis of the factors that are related to pathogenesis and carcinogenesis as a consequence of fiber exposures. ‘

 

• Victor Roggli, M.D., Professor of Pathology, Duke University