1st Edition

Emerging Protein Biotherapeutics

Edited By

Iqbal S. Grewal

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ISBN 9781420063202
Published June 26, 2009 by CRC Press
368 Pages 39 B/W Illustrations

USD $240.00

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Book Description

A Readily Applicable Framework for Novel Drug Design

It is only 20 years since the reach of genetic knowledge has allowed for the development of protein biotherapeutics, but in that time the pace has been fast. While the literature abounds, the field has lacked a comprehensive accounting of this progress. Emerging Protein Biotherapeutics consolidates current knowledge of key protein targets important in autoimmunity and cancers, exploring basic aspects and diverse clinical application.

Presents Strategies to Exploit Therapeutic Uses

In this volume, leading researchers cover many aspects of biology related to protein targets, ranging from the in vivo role in the disease process, to various strategies exploiting development of these targets for therapeutic use. Each chapter includes background, a discussion of clinical implications, an account of preclinical and clinical testing of various candidates, and a listing of key references.

This volume makes the study of protein biotherapeutics accessible at all levels of expertise. It offers an efficient and rational way to grasp the theoretical and experimental knowledge currently available while also providing a deeper understanding of disease processes. Most importantly, it presents a framework that can be readily employed by those looking to develop their own strategies in pursuit of new clinical applications.

Table of Contents


Overview of Antibody-Based Therapeutics: Present and Future Promise, I.S. Grewal


Biologic Therapies for Multiple Sclerosis, P. Fontoura and H. Garren

Biologic Therapies in Rheumatoid Arthritis, M.J. Houseman and J.D. Isaacs

Biologic Therapies in Systemic Lupus Erythematosus, R. Eisenberg

Biologic Therapies for Inflammatory Bowel Disease, M.H. Holtmann and M.F. Neurath

Biologic Therapies for Psoriasis, R. Saraceno and S. Chimenti

TNFa Inhibitors: Emerging Biologic Therapies for the Treatment of Asthma, S. Natarajan, L.J. Vaickus, J. Kim, and D.G. Remick

Protein-Based Therapies in Experimental and Clinical Transplantation, G. Benichou, S. de Haseth, A.B. Cosimi, and A. Alessandrini

Biologic Therapies for Type 1 Diabetes, T.L. Van Belle and M.G. von Herrath


Biologic Therapies for Acute Myeloid Leukemia/Myelodysplastic Syndrome, J. Pinilla-Ibarz and C. Bello

Biologic Therapies for Non-Hodgkin Lymphoma and Hodgkin Disease, S.M. Ansell

Biologic Therapies for Chronic Lymphocytic Leukemia, M.A. Kharfan-Dabaja and E.S. Santos

Biologic Therapies for Multiple Myeloma and Plasma Cell Disorders, S. Ozaki


Antibody-Based Therapies for Carcinomas, D. Schrama and J.C. Becker

Role of Vascular Targeting Agents in the Treatment of Solid Tumors: Current and Future Developments, H.-P. Gerber, I.S. Grewal, and E. Oflazoglu

Recent Advancements in the Use of Antibody–Drug Conjugates for Cancer Therapy, P.D. Senter and D.R. Benjamin


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Iqbal S. Grewal, Ph.D., is a well-established scientist and biotechnologist with many years of research in immunology and oncology. He has extensive experience in the discovery and development of innovative protein-based biotherapeutics in many disease areas. Some of Dr. Grewal’s findings have already helped to translate research into key drug candidates for the treatment of autoimmune diseases and cancers. Currently, he is serving as Vice President of Preclinical Therapeutics at Seattle Genetics and leading preclinical research for the development of monoclonal antibodies and antibody-drug conjugates as therapeutics in the areas of autoimmunity and oncology.