A Readily Applicable Framework for Novel Drug Design
It is only 20 years since the reach of genetic knowledge has allowed for the development of protein biotherapeutics, but in that time the pace has been fast. While the literature abounds, the field has lacked a comprehensive accounting of this progress. Emerging Protein Biotherapeutics consolidates current knowledge of key protein targets important in autoimmunity and cancers, exploring basic aspects and diverse clinical application.
Presents Strategies to Exploit Therapeutic Uses
In this volume, leading researchers cover many aspects of biology related to protein targets, ranging from the in vivo role in the disease process, to various strategies exploiting development of these targets for therapeutic use. Each chapter includes background, a discussion of clinical implications, an account of preclinical and clinical testing of various candidates, and a listing of key references.
This volume makes the study of protein biotherapeutics accessible at all levels of expertise. It offers an efficient and rational way to grasp the theoretical and experimental knowledge currently available while also providing a deeper understanding of disease processes. Most importantly, it presents a framework that can be readily employed by those looking to develop their own strategies in pursuit of new clinical applications.
Table of Contents
Overview of Antibody-Based Therapeutics: Present and Future Promise, I.S. Grewal
BIOLOGICS FOR AUTOIMMUNITY AND INFLAMMATION
Biologic Therapies for Multiple Sclerosis, P. Fontoura and H. Garren
Biologic Therapies in Rheumatoid Arthritis, M.J. Houseman and J.D. Isaacs
Biologic Therapies in Systemic Lupus Erythematosus, R. Eisenberg
Biologic Therapies for Inflammatory Bowel Disease, M.H. Holtmann and M.F. Neurath
Biologic Therapies for Psoriasis, R. Saraceno and S. Chimenti
TNFa Inhibitors: Emerging Biologic Therapies for the Treatment of Asthma, S. Natarajan, L.J. Vaickus, J. Kim, and D.G. Remick
Protein-Based Therapies in Experimental and Clinical Transplantation, G. Benichou, S. de Haseth, A.B. Cosimi, and A. Alessandrini
Biologic Therapies for Type 1 Diabetes, T.L. Van Belle and M.G. von Herrath
BIOLOGICS FOR HEMATOLOGICAL MALIGNANCIES
Biologic Therapies for Acute Myeloid Leukemia/Myelodysplastic Syndrome, J. Pinilla-Ibarz and C. Bello
Biologic Therapies for Non-Hodgkin Lymphoma and Hodgkin Disease, S.M. Ansell
Biologic Therapies for Chronic Lymphocytic Leukemia, M.A. Kharfan-Dabaja and E.S. Santos
Biologic Therapies for Multiple Myeloma and Plasma Cell Disorders, S. Ozaki
DEVELOPMENT OF BIOTHERAPIES FOR SOLID TUMORS
Antibody-Based Therapies for Carcinomas, D. Schrama and J.C. Becker
Role of Vascular Targeting Agents in the Treatment of Solid Tumors: Current and Future Developments, H.-P. Gerber, I.S. Grewal, and E. Oflazoglu
Recent Advancements in the Use of Antibody–Drug Conjugates for Cancer Therapy, P.D. Senter and D.R. Benjamin
Iqbal S. Grewal, Ph.D., is a well-established scientist and biotechnologist with many years of research in immunology and oncology. He has extensive experience in the discovery and development of innovative protein-based biotherapeutics in many disease areas. Some of Dr. Grewal’s findings have already helped to translate research into key drug candidates for the treatment of autoimmune diseases and cancers. Currently, he is serving as Vice President of Preclinical Therapeutics at Seattle Genetics and leading preclinical research for the development of monoclonal antibodies and antibody-drug conjugates as therapeutics in the areas of autoimmunity and oncology.