4th Edition

Encyclopedia of Pharmaceutical Science and Technology, Six Volume Set (Print)

Edited By James Swarbrick
    4296 Pages
    by CRC Press

    Pharmaceutical science deals with the whole spectrum of drug development from start to finish. There are many different facets to the pharmaceutical industry, from initial research to the finished product, including the equipment used, trials performed, and regulations that must be followed. Presenting an overview of all of these different aspects, the Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition is a must-have reference guide for all laboratories and libraries in the pharmaceutical field. Bringing together leaders from every specialty related to pharmaceutical science and technology, this is the single-source reference at the forefront of pharmaceutical R&D.

    The strength of this work is not only its breadth but also the caliber of contributing writers, all experts in their field, writing on all aspects of pharmaceutical science and technology. The fourth edition offers 29 new chapters ranging from biomarkers, computational chemistry, and contamination control to high-throughput screening, orally disintegrating tablets, and quality by design. The encyclopedia details best practices of equipment used, methods for manufacturing, options for packaging, and routes for drug delivery. The volumes also provide a thorough understanding of the choices behind each method. In addition, the regulations, safety aspects, patent guidance, and methods of analysis are presented.

    Key Areas Covered:

    • Analytics
    • Biomarkers
    • Dosage forms
    • Drug delivery
    • Formulation
    • Informatics
    • Manufacturing
    • Packaging
    • Processing
    • Regulatory affairs
    • Systems validation

    This is an authoritative reference source for those practicing in any area of pharmaceutical science and technology, enabling the pharmaceutical specialist and novice alike to keep abreast of developments in this constantly evolving and highly competitive field.

    29 New Chapter Topics:

    Automated Dissolution Testing

    Biomarkers in Drug Discovery and Development

    Computational Chemistry

    Contamination Control: Cleanrooms and Clean Air Devices

    Control of genotoxic impurities in pharmaceutical products

    Crystal Form Analysis of Active Pharmaceutical Ingredients (APIs)

    Drug Delivery using Electrophoresis

    Drug Delivery: Inner Ear

    Drug Transporters in ADME

    Evolutionary Computing and Formulation Optimization

    Freeze Drying of Biologicals

    Good Publication Practice

    High-Throughput Screening (HTS) in Drug Discovery

    Impurity Identification in Pharmaceuticals

    Injection Molding and its Drug Delivery Applications

    Microcalorimetry in Pharmaceutical Development

    Multivariate Statistical Analysis

    Nano-Needle Systems for Vaccine Delivery

    Oral Lipid-Based Formulations

    Orally Disintegrating Tablets

    Parenteral Formulation: Local Injection Site Reaction and Muscle Tolerance

    Particle Shape Analysis

    Proteins and Peptides: Physical and Chemical Stability

    Quality by Design (QbD) and Analytical Method Development

    Quality Target Product Profile (QTPP) for Pharmaceutical Packaging and Delivery Systems

    Quality by Design (QbD) in Freeze Drying

    Scale-Up of Solid Dispersions

    Single-Use Processing in the Pharmaceutical Industry

    Statistical Outliers: Methods and Applications


    James Swarbrick, D.Sc., Ph.D., is the president of PharmaceuTech, Inc., Pinehurst, North Carolina, USA. He has served in a number of industrial and academic positions, including director of product development at Sterling-Winthrop Research Institute, Rensselaer, New York, and vice president for research and development and vice president for scientific affairs at AAIPharma, Wilmington, North Carolina, USA. Prior to joining AAIPharma, he was a professor and chairman of the Division of Pharmaceutics at the University of North Carolina at Chapel Hill School of Pharmacy.

    Dr. Swarbrick is a Fellow of the American Association of Pharmaceutical Sciences, the Royal Society of Chemistry, and the Royal Pharmaceutical Society of Great Britain. He has also served as a member and chairman of the FDA’s Generic Drugs Advisory Committee, as chairman of the PhRMA Foundation’s Pharmaceutics Advisory Committee, as well as a member of the PhRMA Foundation’s Scientific Advisory Committee.

    "…sets the standard in the field and creates the ultimate go-to-guide on all aspects of this ever-evolving area of concentration….this [set] is like having a pharmaceutical library at your fingertips, notable for providing answers to the latest questions in a fascinating field of study."

    -Electric Review

    "…a valuable resource… a good reference for people who work in the pharmaceutical sciences… includes in-depth articles, which are all referenced."
    -Doody's Review Service

    "indispensable for scientists and experts active in various stages of drug development, manufacture, marketing, and regulation."
    -Reaction Kinetics and Catalysis Letters (for previous edition)

    "…The depth and breadth of coverage…make it an excellent source for academic and special libraries supporting research programs in the health sciences, pharmacology, and chemical engineering."
    -American Reference Books Annual (for previous edition)

    "…a valuable, well presented…addition to the literature."
    -The Pharmaceutical Journal (for previous edition)

    "…praiseworthy….The editors and the authors are to be congratulated."
    -Pharmaceutical Technology (for previous edition)

    "…a valuable resource for one who wishes to quickly become familiar with specific topics in pharmaceutics….an up-to-date, expertly written convenience."
    -ARBAonline (for previous edition)

    "…the value of the encyclopedia is in its tremendous breadth….highly recommended…should be in the library of any company or institution involved in pharmaceuticals."
    -Organic Process Research and Development (for previous edition)

    "…a highly recommended set to academic health science libraries….I am not familiar with any other book that offers the same coverage."
    -E-Streams (for previous edition)

    "…Many of the issues addressed are complex, and the editors have succeeded in their efforts to provide up-to-date, concise, and well-written reviews from experts in their respective fields….The quality of this publication justifies its expense in any college of pharmacy, health sciences library or bookstore, or pharmaceutical industry library."
    -Doody's Reviews (for previous edition)