Endogenous and Exogenous Regulation and Control of Physiological Systems: 1st Edition (Hardback) book cover

Endogenous and Exogenous Regulation and Control of Physiological Systems

1st Edition

By Robert B. Northrop

CRC Press

472 pages

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Hardback: 9780849396946
pub: 1999-10-27
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Description

From a biomedical engineering perspective, this book takes an analytic, quantitative approach to describing the basic components of physiological regulators and control systems (PRCs). In Endogenous and Exogenous Regulation and Control of Physiological Systems, the author provides grounding in the classical methods of designing linear and nonlinear systems. He also offers state-of-the-art material on the potential of PRCs to treat immune system ailments, most notably AIDS and cancer.

The book focuses on certain "wet" physiological regulators, such as those using endocrine hormones as parametric control substances. Endogenous and Exogenous Regulation and Control of Physiological Systems includes simulations that illustrate model validations and the putative control of cancer and HIV proliferation. It explores novel, untried immunotherapies on the cutting-edge of PRC treatment and explores the latest technologies.

Table of Contents

INTRODUCTION TO PHYSIOLOGICAL REGULATORS AND CONTROL SYSTEMS

Introduction

Physiology and Physiological Regulation Defined

The Purposes of Modeling

Some General Properties of PRCs

Some General Properties of Linear, Time-Varying, and Nonlinear Systems

Parametric Control

Chapter Summary

PHYSICAL AND CHEMICAL FACTORS GOVERNING THE BEHAVIOR OF PRCS

Introduction

Behavior of Fluidic Systems Under Laminar Flow Conditions

Diffusion Dynamics and Fick's First Law

Mass-Action Kinetics in Chemical Systems

Chapter Summary

Introduction to SISO Control Systems and Systems with Delays

Introduction

Conventional Controllers for Linear Plants with Real Poles

The Use of Root Locus in Linear Control System Design

Some Tests for Stability in Linear and Certain Classes of Nonlinear Systems

Linear Closed-Loop Systems with Delay; Stability Problems

Chapter Summary

INTRODUCTION TO COMPARTMENTAL MODELING AND PHARMACOKINETIC SYSTEMS

Introduction

Basic Compartmental Analysis

The Use of Washout Curves and Bolus Inputs to Identify the Parameters of Simple CPK Systems

Overview of Drug Input controllers

Chapter Summary

SPECIAL TYPES OF CLOSED-LOOP DRUG INPUT CONTROLLERS

Introduction

Design of ON/OFF, Limit-Cycling Controllers for

CPK/P Systems

Nonlinear Decoupling Controllers for Two Input/Two-Output CPK Systems

Integral Pulse Frequency Modulation (IPFM) Bolus Controllers

Introduction to Nonlinear, Parameter Switching Controllers

Chapter Summary

Hormonal Regulation of Sodium, Potassium, and Calcium Ions

Introduction

Implicit Summing Points in Hormonal Regulation

Introduction to the Physiology of the Kidneys

The Regulation of Plasma Sodium Ion Concentration and Osmolarity

Regulation of Plasma Potassium Ions by the Aldosterone System

Calcium Ion Regulation

Magnesium Ion Regulation Chapter Summary

REGULATION OF BLOOD GLUCOSE

Introduction

Molecules Important in Normoglycemic Regulation

The Normal Blood Glucose Regulation System

A Model for Normal Blood Glucose Regulation

The Cobelli and Mari Model for Glucoregulation

Diabetes Mellitus

Exogenous Glucoregulation: The Artificial Beta Cell

Chapter Summary

CONTROL OF MEAN ARTERIAL PRESSURE BY SODIUM NITROPRUSSIDE INJECTION

Introduction

The Pharmacology and Pharmacokinetics of Sodium Nitroprusside

MAP/SNP Controllers Using PI Processing and Smith Delay Compensation

Adaptive and Self-Tuning Controllers for MAP

Chapter Summary

CONTROL OF POST-OPERATIVE PAIN BY SELF-ADMINISTERED OPIOIDS

Introduction

The Neurophysiological and Pharmacological Basis for Pain

The PCA System of Reasbeck and Jacobs

The PCA Model of Liu and Northrop

Chapter Summary

THE HUMAN IMMUNE SYSTEM SEEN FROM A BIOMEDICAL ENGINEERING VIEWPOINT

Introduction

Immune System Cells

Antigen Presentation

Immunocytokines, Their Sources, Effects, and Targets

Apoptosis in the Immune System

The Art of Mathematically Modeling Scenarios in the Immune System

Chapter Summary

SOME SIMULATION PACKAGES SUITABLE FOR MODELING NONLINEAR SYSTEMS

About the Series

Biomedical Engineering

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
TEC059000
TECHNOLOGY & ENGINEERING / Biomedical