Environmental Damage to DNA and the Protective Effects of Phytochemicals provides information on the toxicity of natural as well as synthetic chemicals in the living systems. These can lead to DNA damage and the emergence of serious consequences or manifestations causing varied health hazards. In addition, the ten chapters of the book reflect on the possible applications of plants or plant extracts to impart protection for living cells from the xenobiotics-mediated DNA damage.
The book offers comprehensive coverage of the many essential topics in the subject including:
- Environmental factors and DNA damage
- Molecular mechanisms associated with DNA damage by various environmental (Physical, Chemical and Biological) factors
- Synergistic effects of environmental factors
- Phytochemicals acting both as DNA protectants and genotoxicants
- Experimental models for the study of the genotoxic potential of environmental factors and protection by phytochemicals
This book connects readers who possess a life sciences background to the current understanding, concept and mechanisms involved in environmental-factors-mediated DNA damage. Scientific terms are introduced, defined, described and placed appropriately in the text. The protective effect of some plant extracts/phytochemicals has also been included.
Environmental Damage to DNA and the Protective Effects of Phytochemicals is intended to cater the need of BSc, MSc and research students who are striving to discover the mechanism(s) associated with protection of DNA by plant-based chemicals. This is the first edition of our book and the valuable suggestions and comments from the readers are solicited.
1 Introduction to the environmental factors and DNA damage 1
2 Molecular mechanisms of physical environmental factors as DNA-damage agents with special reference to (A) Radiations and (B) Temperature 13
3 Effects of chemical environmental factors (both natural and anthropogenic) on DNA and their modes of action. A. Organic factors (pesticides, dyes) B. Inorganic Factors (Heavy metals) 25
4 Biological factors causing DNA damage. A. Plant-based molecules. B. Animal-based molecules
5 Synergistic effects of environmental factors on DNA damage. A. Introduction to Synergism B. Synergistic effects C. Mechanism of actions
6 Introduction to phytochemicals and their actions on DNA. A. DNA-damaging action. B. DNA-protective function
7 Phytochemicals as DNA protectants and genotoxicants A. Phytochemicals as genotoxicants. B. Plant extract as DNA protectants. C. Isolated compounds as DNA protectants
8 Role of phytochemicals in protection of DNA from damage by different environmental factors. A. Physical factors (Thermal and radiation). B. Chemical factors (Organic and inorganic). C. Biological factors (Plants and animals)
9 DNA protective and genotoxic potential of environmental factors: Experimental models for the study
10 DNA damage: Overview, conclusion, and future perspective