1st Edition

Enzymology of Complex Alpha-Glucans

Edited By Felix Nitschke Copyright 2022
    298 Pages 15 Color & 43 B/W Illustrations
    by CRC Press

    298 Pages 15 Color & 43 B/W Illustrations
    by CRC Press

    298 Pages 15 Color & 43 B/W Illustrations
    by CRC Press

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    Glycogen and Starch: So Similar, yet so Different. Both carbohydrates are central to the primary metabolism of a large part of the living kingdom. Generally, animals, fungi, and bacteria store glycogen, while plants largely rely on starch. This book provides a broad and current view on both glycogen and starch, in lower and higher organisms. Beside biochemistry, physiology and regulation of glycogen and starch metabolism, the reader can expect an insight into glycogen storage diseases, select methods and relevant techniques. While significant progress has been made in both fields, this volume emphasizes an opportunity of collaboration for researchers working on a major intersection of the living world.

    Morphological and Structural Aspects of a -Glucan Particles from Electron Microscopy Observations

    Jean-Luc Putaux

    Polarimetric Nonlinear Microscopy of Starch Granules: Visualization of the Structural Order of α-Glucan Chains within a Native Starch Particle

    Danielle Tokarz, Richard Cisek and Virginijus Barzda

    Analyses of Covalent Modifications in α-Glucans

    Felix Nitschke and Peter Schmieder

    Storage Polysaccharide Metabolism in Micro-Organisms

    Christophe Colleoni

    Mammalian Glycogen Metabolism: Enzymology, Regulation, and Animal Models of Dysregulated Glycogen Metabolism

    Bartholomew A. Pederson

    The Pathologies of a Dysfunctional Glycogen Metabolism

    Mitchell A. Sullivan, Berge A. Minassian and Felix Nitschke

    Reversible Phosphorylation in Glycogen and Starch

    Katherine J. Donohue, Andrea Kuchtova, Craig W. Vander Kooi and Matthew S. Gentry

    Starch Granules and their Glucan Components

    Eric Bertoft

    Regulation of Assimilatory Starch Metabolism by Cellular Carbohydrate Status

    Maria Grazia Annunziata and John Edward Lunn

    Reserve Starch Metabolism

    Yasunori Nakamura

    Heteromeric Protein Interactions in Starch Synthesis

    Michael J. Emes, Gregory J. MacNeill and Ian J. Tetlow


    Felix Nitschke received his Ph.D. from the University of Potsdam, Germany (2013), under Dr. Martin Steup, an accomplished expert in starch metabolism. Early on Dr. Nitschke’s work focused on particular glycogen storage diseases where pathological insoluble "starch-like" glycogen particles are accumulating, and for instance, drive the progressive childhood-onset epilepsy Lafora disease. After a post-doc under Dr. Berge Minassian at The Hospital for Sick Children, Toronto, Canada, Dr. Nitschke was recruited as Assistant Professor at UT Southwestern Medical Center.