The concept of epigenetics has been known about since the 1940s, but it is only in the last 10 years that research has shown just how wide ranging its effects are. It is now a very widely-used term, but there is still a lot of confusion surrounding what it actually is and does.
Epigenetics is a new textbook that brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It is a valuable source of information about all aspects of the subject for undergraduate students, graduate students, and professionals.
Table of Contents
Chapter 1. Introduction to the Study of Epigenetics
Chapter 2. The Basis of the Transcription Process
Chapter 3. DNA Packaging and Chromatin Architecture
Chapter 4. Modifying the Structure of Chromatin
Chapter 5. DNA Methylation
Chapter 6. Post-Translational Modification of Histones
Chapter 7. Histone Modification Machinery
Chapter 8. Locus-Specific Control of Histone-Modifying Enzyme Action
Chapter 9. Epigenetic Control of Cell-Specific Gene Expression
Chapter 10. Epigenetic Control of the Mitotic Cell Cycle
Chapter 11. The Epigenetic Basis of Gene Imprinting
Chapter 12. Epigenetic Control of Cellular Differentiation
Chapter 13. Reversibility of Epigenetic Modification Patterns
Chapter 14. Epigenetic Predisposition to Disease and Imprinting-Based Disorders
Chapter 15. Epigenetics of Memory, Neurodegeneration, and Mental Health
Chapter 16. Epigenetics of Cancer
"Armstrong’s Epigenetics textbook is not only timely but also important for introducing scientists, new and seasoned, to the ever-evolving world of epigenetics."
- The Quarterly Review of Biology, 2016, Vol. 91, No. 2
"The author has made a very thorough presentation of several areas within the field of epigenetics. The material has been presented in a comprehensive, well-organized and understandable manner. He allows the reader to gain a strong foundation of each subject area by including detailed introductory sections. The coverage of the topics will allow the reader to obtain both general knowledge and also more detailed understanding of the regulating mechanisms involved in epigenetic changes and the consequences of those changes.The content is also relevant to current trends in the field of epigenetics and includes reviews of disease states related to epigenetics, such as cancer, which are actively being researched."
"In summary, Epigenetics provides a convincing overview of epigenetic mechanisms at the molecular and cellular levels. Clearly, such mechanisms are likely to be relevant to many complex human diseases, but the details remain to be elucidated. The enduring impression taken away from this book is of a spectacularly complex and dynamic interplay among different epigenetic factors in the regulation of gene expression and cellular differentiation. Any researcher interested in these phenomena should find this textbook an excellent resource."
- International Journal of Epidemiology, 2015, Vol. 44, No. 4