1st Edition

Experimental Liver Transplantation

By Naoshi Kamada Copyright 1988

    First Published in 1988, Experimental Liver Transplantation is a helpful guide through the process of Liver Transplantation and how the surgical techniques have evolved over the years. Filled with references to the history of Liver transplantation, to the experimental procedures performed on rats. This is an essential guide to any students of surgery or professionals in their respective fields.

    1. Historical Background to experimental Liver Transplantation.  2. Surgical Techniques for Rat Liver Transplantation.  3. Surgical Techniques for Rat Heart and Kidney Transplantation.  4. Transplantation Antigens in Rat Liver Grafting.  5. The Processes of Rejection and Nonrejection – Histology and Functional Competence of Rat Livers after Transplantation.  6. Genetics of Liver Graft Rejection in the Rat.  7. Systemic Tolerance Induced by Liver Transplantation.  8. Immunosuppression by Liver Transplantation.  9. Sensitization by Auxiliary Liver Grafting or Liver Cell Suspensions.  10. Serology of Liver Transplantation in the Rat.  11. Immunosuppressive Properties of Serum and Lymph from Liver Grafted Rats.  References.  Index.


    Naoshi Kamada, M.D., Ph.D. (Cantab) is Director of Experimental Surgery at the National Children’s Medical Research Center, Tokyo, Professor of Kobe University School of Medicine, Japan, and Visiting Professor of Surgery, University of Cordoba, Spain. After reading Medical sciences in Japan, Professor Kamada was a research and clinical fellow in transplantation under Sir Roy Y. Calne in the Department of Surgery, University of Cambridge, England, Starting in 1977. He was then a research student at Trinity Hall, Cambridge, receiving his Ph.D. in 1982 for a dissertation on the subject of tolerance induced by liver transplantation in the rat. Since then, most of his research career has been spent in the Department of Surgery, University of Cambridge, England. In 1986 he assumed his present appointments in Japan. Most of Professor Kamada’s research has been spent in the area of liver transplantation using rats. In 1979 he developed a technique using cuffs for orthotopic rat liver transplantation (OLT). Since then he has performed these operations in over 1300 cases. Using this rat model, he reported that liver transplants did not obey the normal rules of transplantation. His recent work has been concerned with mechanisms of tolerance and antigen-specific immunosuppression induced by OLT. He has published over 50 papers in immunology and surgical techniques. He was awarded with the Jean Morelle Prize from the La Fondation Jean Morelle, Brussels, Belgium, in 1982, and the Darlington Prize, Darlington, England, in 1987.