1st Edition

Experimental Models of Diabetes

Edited By

John H. McNeill




ISBN 9780849316678
Published January 27, 1999 by CRC Press
424 Pages 3 B/W Illustrations

USD $210.00

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Book Description

An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models.
Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models.

Table of Contents

The STZ-Induced Diabetic Rat
STZ-Induced Diabetes: Induction, Mechanism(s), and Dose-Dependency, B. Rodrigues, P. Poucheret, M. Battell, and J.H. McNeill
Alternations in Myocardial Energy Metabolism in Streptozotocin Diabetes, W. C. Stanley, G.D. Lopaschuk, and K.M. Kivilo
Structural and Functional Consequences of Streptozotocin-Induced Diabetes on the Kidney, K. Sharma, D.C. Han, A. Mogyorosi, and F.N. Ziyadeh
Physiological and Pathological Consequences of STZ-Diabetes on the Heart, B. Rodrigues and J.H. McNeill
The Effects of STZ-Induced Diabetes on the Cytochrome P450 System and Other Metabolic Pathways, C. Ionnides, P.R. Flatt, and C.R. Barnett
Nerve and Retinal Changes in Experimental Diabetes, S. Chakrabarti
Vascular Reactivity in Streptozotocin-Induced Diabetes, R. Subramanian and K.M. MacLeod
Cardiovascular Function in the Intact, STZ-Treated Rat, R. A. Hebden
Treatment and Pharmacological Interventions in STZ -Diabetes, M.L. Battell, B. Rodrigues, V.G. Yuen, and J.H. McNeill
Other Experimental Models of Diabetes
Other Models of Type I Diabetes, M.L. Battell, V.G. Yuen, S. Verman, and J.H. McNeill
Spontaneous Insulin Dependent Diabetes Mellitus (IDDM) in Nonobese Diabetic (NOD) Mice: Comparisons with Experimentally Induced IDDM, E.H. Leiter, I.C. Gerling, and J.C. Flynn
The Neonatal-STZ Model of Diabetes, S.W. Schaffer and M. Mozaffari
The BB Rat: A Unique Model of Human Type 1 Diabetes, C.J. Field and S. Butler
Non-Insulin Dependent Animal Models of Diabetes Mellitus, C.H.S. McIntosh and R.A. Pederson

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