1st Edition

Experimental Models of Diabetes

Edited By John H. McNeill Copyright 1999
    424 Pages 3 B/W Illustrations
    by CRC Press

    An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models.
    Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models.

    The STZ-Induced Diabetic Rat
    STZ-Induced Diabetes: Induction, Mechanism(s), and Dose-Dependency, B. Rodrigues, P. Poucheret, M. Battell, and J.H. McNeill
    Alternations in Myocardial Energy Metabolism in Streptozotocin Diabetes, W. C. Stanley, G.D. Lopaschuk, and K.M. Kivilo
    Structural and Functional Consequences of Streptozotocin-Induced Diabetes on the Kidney, K. Sharma, D.C. Han, A. Mogyorosi, and F.N. Ziyadeh
    Physiological and Pathological Consequences of STZ-Diabetes on the Heart, B. Rodrigues and J.H. McNeill
    The Effects of STZ-Induced Diabetes on the Cytochrome P450 System and Other Metabolic Pathways, C. Ionnides, P.R. Flatt, and C.R. Barnett
    Nerve and Retinal Changes in Experimental Diabetes, S. Chakrabarti
    Vascular Reactivity in Streptozotocin-Induced Diabetes, R. Subramanian and K.M. MacLeod
    Cardiovascular Function in the Intact, STZ-Treated Rat, R. A. Hebden
    Treatment and Pharmacological Interventions in STZ -Diabetes, M.L. Battell, B. Rodrigues, V.G. Yuen, and J.H. McNeill
    Other Experimental Models of Diabetes
    Other Models of Type I Diabetes, M.L. Battell, V.G. Yuen, S. Verman, and J.H. McNeill
    Spontaneous Insulin Dependent Diabetes Mellitus (IDDM) in Nonobese Diabetic (NOD) Mice: Comparisons with Experimentally Induced IDDM, E.H. Leiter, I.C. Gerling, and J.C. Flynn
    The Neonatal-STZ Model of Diabetes, S.W. Schaffer and M. Mozaffari
    The BB Rat: A Unique Model of Human Type 1 Diabetes, C.J. Field and S. Butler
    Non-Insulin Dependent Animal Models of Diabetes Mellitus, C.H.S. McIntosh and R.A. Pederson


    John H. McNeill