Experimental Models of Diabetes: 1st Edition (Hardback) book cover

Experimental Models of Diabetes

1st Edition

Edited by John H. McNeill

CRC Press

424 pages | 3 B/W Illus.

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Hardback: 9780849316678
pub: 1999-01-27
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An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models.

Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models.

Table of Contents

The STZ-Induced Diabetic Rat

STZ-Induced Diabetes: Induction, Mechanism(s), and Dose-Dependency, B. Rodrigues, P. Poucheret, M. Battell, and J.H. McNeill

Alternations in Myocardial Energy Metabolism in Streptozotocin Diabetes, W. C. Stanley, G.D. Lopaschuk, and K.M. Kivilo

Structural and Functional Consequences of Streptozotocin-Induced Diabetes on the Kidney, K. Sharma, D.C. Han, A. Mogyorosi, and F.N. Ziyadeh

Physiological and Pathological Consequences of STZ-Diabetes on the Heart, B. Rodrigues and J.H. McNeill

The Effects of STZ-Induced Diabetes on the Cytochrome P450 System and Other Metabolic Pathways, C. Ionnides, P.R. Flatt, and C.R. Barnett

Nerve and Retinal Changes in Experimental Diabetes, S. Chakrabarti

Vascular Reactivity in Streptozotocin-Induced Diabetes, R. Subramanian and K.M. MacLeod

Cardiovascular Function in the Intact, STZ-Treated Rat, R. A. Hebden

Treatment and Pharmacological Interventions in STZ -Diabetes, M.L. Battell, B. Rodrigues, V.G. Yuen, and J.H. McNeill

Other Experimental Models of Diabetes

Other Models of Type I Diabetes, M.L. Battell, V.G. Yuen, S. Verman, and J.H. McNeill

Spontaneous Insulin Dependent Diabetes Mellitus (IDDM) in Nonobese Diabetic (NOD) Mice: Comparisons with Experimentally Induced IDDM, E.H. Leiter, I.C. Gerling, and J.C. Flynn

The Neonatal-STZ Model of Diabetes, S.W. Schaffer and M. Mozaffari

The BB Rat: A Unique Model of Human Type 1 Diabetes, C.J. Field and S. Butler

Non-Insulin Dependent Animal Models of Diabetes Mellitus, C.H.S. McIntosh and R.A. Pederson

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Endocrinology & Metabolism
MEDICAL / Pharmacology
MEDICAL / Research