What agents should be measured?
How should measurement be performed and what averaging time should be used for the measurement?
What sampling strategy should be employed to characterize exposures across individuals, locations, and time?
What durations of exposure should be characterized?
What statistical descriptors should be used to relate exposure to effect?
Exposure Assessment for Epidemiology and Hazard Control examines various approaches to answering these and other important questions. Other topics discussed include the measurement of current exposures (e.g., vapors, gases, aerosols, and complex mixtures); the application of toxicological relationships, including biological markers and sample models; an epidemiological evaluation of exposure-effect relationships, including new methods for effect evaluation and models for population exposure estimates; and strategies for exposure assessment, such as biological sampling interpretation through toxicokinetic processes. This important new volume contains essential information for industrial hygienists, epidemiologists, occupational health physicians, toxicologists, and immunologists.
SECTION I: MEASUREMENT of CURRENT EXPOSURES. Alternative Ways of Monitoring Occupational Exposure. Measurement of Vapors and Gases. The Measurement of Aerosols in Relation to Risk Assessment. The Use of Markers to Measure Exposures to Complex Mixtures. Rapporteur's Summary: Measurement of Current Exposures. SECTION II: APPLICATION of TOXICOLOGICAL RELATIONSHIPS. Assessing Relevant Exposures to Airborne Irritants. Exposure-Dose Relationships. Development of Biological Monitoring as a Tool for Exposure Assessment. The Use of Models to Investigate the Toxicokinetic Behavior of Organic Solvents. Rapporteur's Summary: Application of Toxicological Relationships. SECTION III: EPIDEMIOLOGIC EVALUATION of EXPOSURE-EFFECT RELATIONSHIPS. Issues in the Epidemiologic Evaluation of Exposure-Effect Relationships. New Methods for Evaluating Health Effect. Retrospective Exposure Assessment-A Review of Approaches and Directions for the Future. Exposure Assessment Challenges Presented by Investigations of Reproductive Effects in the Semiconductor Industry. Rapporteur's Summary: Epidemiologic Evaluation of Exposure-Effect Relationships. SECTION IV: EXPOSURE ASSESSMENT STRATEGIES. Exposure Assessment Strategies. Biological Monitoring Strategies. Sampling Strategies for Epidemiological Studies. Individual Versus Group Differences in Exposure Risk. Rapporteur's Summary: Exposure Assessment Strategies. Index.