1st Edition

Fertility, Reproduction, and Treatment From Basics to Precision Medicine

538 Pages
by CRC Press

This book provides a comprehensive primer on human reproduction, beginning with normal pre-implantation embryo development. It starts with gametogenesis, followed by fertilization, embryo development, and implantation, with each section describing the molecular aspects of each phase. The focus then moves to highlight putative factors that influence fertility, such as environment and lifestyle,... Read more

Introduction

George Anifandis, Stephen A. Krawetz and Peter Sutovsky

 

Section I: BIOLOGY OF REPRODUCTION

1. A concise overview of mammalian spermatogenesis

Tasrin Sultana and Peter Sutovsky

 

2. Molecular mechanisms of folliculogenesis and oogenesis

Mohamed Aboul Ezz and Ahmed Zaky Balboula

 

3. Fertilization and oocyte activation: overview, updates, and novel hypotheses from a molecular perspective

Valentina Di Nisio, Peter Sutovsky, Sevastiani Antonouli, Christina Messini, Katerina Chatzimeletiou, Georgia Kokkali and George Anifandis

 

4. Early embryo development: the current perspective in molecular evaluation and clinical status

Sevastiani Antonouli, Dimitrios Ioannou, Valentina Di Nisio, Christina Messini, Georgia Kokkali, Katerina Chatzimeletiou, Peter Sutovsky, Alexandos Daponte and George Anifandis

 

5. Human placentation: foundations and implications for reproductive endocrinology and infertility

Elakkiya Prabaharan, D. Randall Armant and Sascha Drewlo

 

6. Regulation of the brain-placental axis, and its relevance to the health and disease of the offspring

Susanta K. Behura

 

Section II: BIOLOGY OF INFERTILITY

 

7. Overview of Infertility

Awoniyi O. Awonuga, Olivia G. Camp, Mia M. Biernat and Husam M. Abu-Soud

 

8. Male infertility

Opeyemi Dhikhirullahi and Zhibing Zhang

    

9. Insight into the complexity of male infertility: a multi-omics review

Rebeka Podgrajsek, Alenka Hodzic, Martin Stimpfel, Tanja Kunej and Borut Peterlin

 

10. The biology and clinical aspects of female infertility

Mitko Madjunkov, Svetlana Madjunkova and Clifford Librach

 

11. Reproductive microbiota in humans: characterization and role in infertility

Rebecca Poole, Dallas Soffa, Kyle Hickman, Olivia Ognibene and Matthew Stuehr

 

12. The genetic basis of male and female infertility

Dimitrios Ioannou and Helen G. Tempest

 

Section III: ASSISTED REPRODUCTION

 

13. Ovarian stimulation protocols in fresh cycles and in elective freeze-all cycles

Ioannis E Messinis, Christina I. Messini and George Anifandis

 

14. In vitro fertilization, intracytoplasmic sperm injection, in vitro maturation, and embryo culture

Leah Cooper, Emma Manuel, Min Xu and Samantha B. Schon

 

15. In vitro maturation of oocytes (IVM): historical landmarks, current status and future perspectives

Katerina Chatzimeletiou, Konstantina Pappa, Nikos Petrogiannis, George Anifandis, Kalliopi Chatzovoulou, Elias Tsakos, Efstratios Kolibianakis, Grigoris Grimbizis and Antonia Sioga

 

16. Cryopreservation in human reproductive medicine

Yuksel Agca and Levent Keskintepe

 

Section IV: ADVANCED ISSUES IN ASSISTED REPRODUCTION

 

17. Navigating male infertility through testicular biopsy: outcomes, predictive parameters, and surgical innovation

Maria Filiponi and Athanasios Zachariou

 

18. Viruses and assisted reproductive technologies (ART)

Marina Leiva, Maria Lopez-Panades, Di Wang, Mar Domingo-Lopez, Judit Castillo, Ignasi Roig, Rafael Oliva and Meritxell Jodar

 

19. Bioethics in assisted reproduction and embryology

George Anifandis, Helen G. Tempest, Dimitrios Ioannou, Peter Sutovsky, Christina Messini, Katerina Chatzimeletiou, Eleni Zagelidou and Georgia Kokkali

 

20. Navigating the practical challenges and ethical dilemmas of surplus cryopreserved human embryos

George Anifandis, Dimitrios Ioannou, Georgia Kokkali, Katerina Chatzimeletiou, Christina Messini, Sevastiani Antonouli and Helen G. Tempest

 

21. Future directions in infertility research: the role of generative AI and large language models

Hasan M. Jamil

 

Multiple-Choice Questions: Answer Key and Explanations

Biography

George Anifandis is a Professor of Embryology in the Faculty of Medicine at the University of Thessaly in Greece. He is the Director of the Histology and Embryology Department, Laboratory Director of the IVF Unit of the Obstetrics and Gynaecology Department of the University Hospital of Larisa in Greece. He has published more than ninety papers in high-impact factor journals related to sperm and embryo quality and serves as an Associate Editor in more than three international journals, along with his position on the Editorial Board of Systems Biology in Reproductive Medicine.

Stephen A. Krawetz is the Charlotte B. Failing Professor of Fetal Therapy and Diagnosis, C.S. Mott Center for Human Growth and Development, Wayne State University. He is a Fellow of the American Association for the Advancement of Science  and the founding Editor-in-Chief of Systems Biology in Reproductive Medicine. His group established that the fitness of the paternal contribution reflects the relative diversity of sperm RNAs as they respond to the environment. They provide a personalized timestamp of the physical and reproductive health of the male.

Peter Sutovsky is Professor of Animal Science at the University of Missouri College of Agriculture, Food and Natural Resources and Professor of Obstetrics, Gynecology and Women's Health at the University of Missouri School of Medicine. His research focuses on mammalian gametogenesis, fertilization, and embryonic development, with emphasis on the ubiquitin-proteasome system. He is a Founding Associate Editor of Systems Biology in Reproductive Medicine, a Fellow of the American Association for the Advancement of Science and a Distinguished Fellow of The Society for the Study of Reproduction.