This timely volume highlights current knowledge concerning the role of fibronectin in human biology and medicine. It is intended to stimulate further investigation in this area. Emphasized are the importance of fibronectin in the interaction between the cell and its environment; and the role of the fibronectin in the determination of cell behavior in normal physiologic processes, in malignant behavior of cells, and in inflammatory disease. This book is valuable to those in the biomedical community interested in fibronectin, the microenvironment and extracellular matrix. It is also important to those interested in the pathobiochemistry of malignant disease and inflammatory disorders.
Table of Contents
1. The Structure and Function of Fibronectins 2. Fibronectin in Development 3. Fibronectin and Aging 4. Fibronectin- Role in Phagocytic Host Defense and Lung Vascular Integrity 5. Fibronectin Interactions with Complement Proteins-Characteristics of the Binding Interactions and Potential Biologic Significance 6. Interactions Between Fibronectin and Bacteria 7. Fibronectin and Polymorphonuclear Neutrophil Function 8. Fibronectin and Monocyte Receptor Function 9. Fibronectin and Platelet Function 10. Fibronectin and Blood Coagulation 11. Fibronectin and Cancer- Implications of Cell Adhesion to Fibronectin for Tumor Metastasis 12. Fibronectin in the Skin 13. Fibronectin in the Lung 14. Fibronectin in Liver Disease 15. Fibronectin in Cartilage 16. Fibronectin and Rheumatic Disease 17. Fibronectin in Animal Models of Inflammation and Autoimmune Diseases