Flavonoids for Neurological Disorders Advances and Future Prospects

Preface

Foreword by Dr. Prabhat Kumar Singh

1. Source, Chemistry, and Extraction Methods of Flavonoids

Innocent Mary Ifedibaluchukwu Ejiofor, Christabel Chikodi Ekeomodi, and Mary Ololade Akinlade

2. Introduction and Classification of Flavonoids

Sharda Sambhakar, Bishambar Singh, Samriti Faujdar, and Bhawana Sati

3. Extraction Methods for Flavonoids Using Advanced Techniques

Rosa Isela Guzmán-Gerónimo, Isela Santiago-Roque, Micloth López Del Castillo Lozano, Carmen Bulbarela-Sampieri, and Rafael Fernández-Demeneghi

4. Health Benefits of Flavonoids: A Review

Athira. E, Shinta Davis, Sofia Rachel, and Vijisha. K. Rajan

5. Potential Role of Flavonoids Against Dementia and Alzheimer’s Disease

Salkiæ Adna, Badnjeviæ Meliha, Koriæ Emina, And Gušiæ Irma

6. Flavonoids and Synaptic Plasticity in the Central Nervous System: Mechanisms and Therapeutic Implications

Sijina K. P. and Rajanikant G. K.

7. Flavonoids and the Aging Brain: Insights into Mechanisms and Therapeutic Potential

Navami Krishna and Rajanikant G. K.

8. Flavonoids as a Natural Approach to Alleviate Neuroinflammation and Improve Neurological Health

Lubna M. A. and Rajanikant G. K.

9. Interaction of Flavonoid with Neural Signaling Pathways for Neural Protection

Anmol Saxena, Rishabha Malviya, and Vinod Kumar Tiwari

10. Potential Role of Flavonoids Against Parkinson’s and Huntington’s Disease

Suraj Kumar, Rishabha Malviya, and Vinod Kumar Tiwari

11. Curcumin as a Neuroprotective Agent

Naureen Rizvi, Mohd Muazzam Khan, and Usama Ahmad

12. Cyanidin as a Potential Flavonoid for Curing Oxidative Stress in Biological Systems

Shinta Davis, Vijisha. K. Rajan, Athira E., and K. Muraleedharan

13.Naringenin as a Potential Flavonoid for Neurological Disorders

Neenu Krishna P.U and Muraleedharan K.

14. Methods for Extraction and Analysis of Flavonoids in Common (Fagopyrum esculentum Moench) and Tartary (Fagopyrum tataricum L.) Buckwheat and Their Products

Amela Džafiæ, Enisa Omanoviæ-Miklièanin, and Sanja Oruèeviæ Žuljeviæ

15. Kaempferol as a Neuroprotective Agent

Harsh Yadav, Rishabha Malviya, and Niranjan Kaushik

16. Exploring the Properties of Curcumin as a Multifunctional Neuroprotective Agent: A Therapeutic Insights with Mechanism of Action

M. A. Jaseela and K. Muraleedharan

Index

Biography

Rishabha Malviya, PhD, has 11 years of research experience and is presently working as Associate Professor in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, India. His areas of interest include formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients. He has authored more than 150 research/review papers for national/international journals of repute. He has over 50 patents to his name and many publications in reputed national and international journals (with a total of 91 cumulative impact factor). He received an Outstanding Reviewer Award from Elsevier. He has edited books (Wiley, Springer Nature, CRC Press/Taylor and Francis, Apple Academic Press, River Publisher, Lambert, etc.) and authored 15 book chapters. His name has been included in the Stanford University’s World’s Top 2% Scientists, 2020 by Elsevier BV and Stanford University. He is reviewer, editor, and editorial board member of more than 50 national and international journals. He was an invited author for the magazine Atlas of Science as well as a pharma magazine dealing with the B2B industry, Ingredients South Asia.

Kamla Pathak, PhD, is Dean and Professor, Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah, India. With teaching and research experience of more than 30 years, she is actively engaged in research on oral controlled, modulated, and targeted and topical drug delivery systems, and has received many awards for her work. She has over 270 publications in journals of international and national repute. She also holds three patents and has authored four books and more than 20 book chapters. She has also written many abstracts in various scientific forums and has been a reviewer for national and international journals in pharmaceutics. Professor Pathak has served as a member of the editorial advisory board of AAPS PharmSciTech and is also a member of various professional bodies. She has guided more than 120 PhD and postgraduate students. She is also associated with the Indian pharmaceutical industry in the capacity of a scientific consultant. She is credited as a reviewer of several scientific projects including Knowledge Foundation, Sweden, and Israel Science Foundation. She has participated at national and international seminars and conferences as organizer, invited speaker, and chairperson of scientific sessions. She has been listed in the top 2% Indian scientists in the subsection Pharmacology and Pharmacy, in the World’s Top 2% Scientists list released by Stanford University in 2020 and 2021. She graduated (Pharmaceutics) from the University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India, earning her doctorate in Pharmacy in 1991 from the same institute.

Shraddha Dwivedi, PhD, is currently employed as Head and Assistant Professor in the Department of Zoology, Government Degree College, Haripur, Nihastha, Raebareli, Uttar Pradesh, India. The topic of her research work was “Anti-oxidative and suppressive potential of certain flavonoid plant extracts against As (lll induced genotoxic stress in the fish Channa punctatus (Bloch).” She has a strong academic background with 10 years of research experience. She has authored several research articles published in high impact journals and has presented research papers in seminars and conferences. She has also received a best poster award at the Indian Science Congress held in Mumbai. She has edited one book and authored three book chapters with national and international publisher (Apple Academic Press). She has also received a Congress of Zoology Medal for outstanding research and academic contribution in the field of fish and fisheries by the Zoological Society of India.

Sonali Sundram, MPharm, is Assistant Professor in the School of Medical & Allied Sciences at Galgotias University, Greater Noida, Uttar Pradesh, India. Previously, she worked as a research scientist on a project of the Indian Council of Medical Research at King George’s Medical University, Lucknow, India. After that, she joined BBDNIIT (Babu Banarasi Das Northern India Institute of Technology), Lucknow. Her PhD (Pharmacy) work is in neurodegeneration and nanoformulation. Her areas of interest include neurodegeneration, clinical research, and artificial intelligence. She has edited four books (Wiley, CRC Press/Taylor and Francis, River Publisher) and has organized more than 15 national and international seminars, conferences, and workshops. She has more than eight patents, both national and international, to her credit.

“A thorough compilation painstakingly put together by editors Dr. Rishabha Malviya and Dr. Kamla Pathak. This book provides an important source of understanding about an expanse of prospective remedies in which neurological illnesses pose more complicated obstacles to human health and well-being. . . . Brings readers through the complex world of flavonoids. The introductory chapters of the book explore the underlying chemistry, sources, and biological functions of flavonoids. The subsequent subsequent explores sophisticated extraction methods, categorization, and possible health advantages. As the book progresses, it delves deep into neurological illnesses, revealing how flavonoids may be crucial in the fight against neurodegenerative diseases.”

—From the Foreword by Dr. Prabhat Kumar Singh, Vice Chancellor, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India