Flexible Imputation of Missing Data, Second Edition: 2nd Edition (Hardback) book cover

Flexible Imputation of Missing Data, Second Edition

2nd Edition

By Stef van Buuren

Chapman and Hall/CRC

416 pages | 76 Color Illus.

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Hardback: 9781138588318
pub: 2018-07-16
eBook (VitalSource) : 9780429492259
pub: 2018-07-17
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Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem.

This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field.

This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.


Praise for the first edition:

"As an applied biostatistician, the introductory chapter spoke directly to me. It began motivating the issues in multiple imputation from the perspective of applied data problems and problematic approaches to them…Foundational examples start with simple scenarios that are gradually and clearly expanded upon. At each step, R code is shown and illustrations visually show the effects of different approaches. For every major concept there is a half-page "Algorithm Box", a short summary in pseudo-code of the algorithm being discussed. These, in conjunction with the explanatory text, made things extremely clear and easy to grasp… Overall, this book does an excellent job of bringing one from no knowledge of multiple imputation to a working knowledge of multiple imputation."

—ISCB News, July 2016

"The opening chapters of this book will be useful to the newcomer to missing data, including the nonstatistician. Many of the recommendations in the ‘Do’s and don’ts’ section will be useful to the researcher who encounters missing data and wishes to deal with it responsibly. Finally, the code examples provide a reassuring companion to the user of the mice software package."

—Biometrical Journal, 2014

"This book would be well suited as a textbook, especially at the graduate level, possibly for biostatisticians, epidemiologists, or applied scientists and users of statistical methodology. …a very enjoyable read, and—at least in my opinion—it is a book that belongs on everyone’s shelf as it does open one’s eyes to a problem that has surrounded us (and that many of us have ignored!) for a very long time."

—Wolfgang S. Jank, Journal of the American Statistical Association, June 2013

"From the first lines of Chapter 1 throughout the entire monograph, the author presents numerous R language codes, so the book also serves as a good introduction to R. Each chapter is complete with various examples and exercises. The book is very useful to graduate students and researchers for solving practical problems with real data."

—Technometrics, February 2013

"It’s excellent and I highly recommend it. … van Buuren’s book is great even if you don’t end up using the algorithm described in the book … he supplies lots of intuition, examples, and graphs."

—Andrew Gelman, Columbia University

"… a beautiful book that is so full of guidance for statisticians … exceptionally up to date and has more useful wisdom about dealing with common missing data problems than any other source I've seen."

—Frank Harrell, Vanderbilt University

"I’m delighted to see this new book on multiple imputation by Stef van Buuren …This book represents a 'no nonsense' straightforward approach to the application of multiple imputation. I particularly like Stef’s use of graphical displays … It’s great to have Stef’s book on multiple imputation, and I look forward to seeing more editions as this rapidly developing methodology continues to become even more effective at handling missing data problems in practice."

—From the Foreword by Donald B. Rubin

Table of Contents


Multiple imputation

Univariate missing data

Multivariate missing data

Analysis of imputed data

Imputation in practice

Multilevel multiple imputation

Individual Causal Effects

Measurement issues

Selection issues

Longitudinal data


About the Author

Stef van Buuren is a statistical consultant at the Netherlands Organisation for Applied Scientific Research TNO in Leiden with a broad knowledge of quantitative issues in public health. Since 2015, Van Buuren holds is the world's first Professor of Missing Data at the department of Methodology & Statistics, FSS, University of Utrecht. He is the originator of various new statistical tools.

About the Series

Chapman & Hall/CRC Interdisciplinary Statistics

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Subject Categories

BISAC Subject Codes/Headings:
MATHEMATICS / Probability & Statistics / General