1st Edition

Functional Lipid Nanosystems in Cancer

    712 Pages 44 Color & 21 B/W Illustrations
    by Jenny Stanford Publishing

    712 Pages 44 Color & 21 B/W Illustrations
    by Jenny Stanford Publishing

    Cancer remains one of the most challenging issues in modern medicine, being responsible for a high number of deaths every year. Recent important developments in cancer diagnosis and therapy based on the versatility of nanosystems have made it possible to incorporate multifunctional synergistic actions into a single delivery system.

    This book compiles the research on the use of functional lipid nanosystems that combine different strategies in one single nanosystem to enhance overall cancer treatment. Besides providing an overview of the current functional nanosystem strategies, it also offers researchers essential theoretical background on cancer, the physiological barriers to its treatment, aspects related to the design and optimization of nanocarriers for cancer treatment, and clinical developments, including promises, safety issues, and the expected future. The editors bring together a group of scientists from all over the world to discuss the most relevant issues and to provide updates on functional lipid nanosystems and cancer.

    Part 1: General Aspects of Cancer Pathology and Treament Options 
    1. Physiological Barriers in Cancer: A Challenge to Be Overcome 
    Livia P. Mendes, Can Sarisozen, and Vladimir P. Torchilin 
    2. Cancer Chemotherapy, Bioactive Compounds, and Immunotherapy 
    Eva Fischer-Fodor, Alina Andreea Zimta, Mihail Buse et al. 
    Part 2: General Aspects of Functional Lipid Nanotherapy 
    3. General Aspects of a Multifunctional Nanosystem 
    Marlene Lúcio, Maria Elisabete C. D. Real Oliveira, and Carla M. Lopes 
    Part 3: Multifunctional Lipid Nanosystems for Cancer: Research Highlights 
    4. Co-delivery of Anticancer Therapeutics via Lipid-Based Nanoscale Delivery Systems 
    Yao Fu 
    5. Lipid-Based Nanocarriers for Co-delivery of Anticancer Drugs and Natural Compounds 
    Eduarda Fernandes, Telma Soares, Carla M. Lopes et al. 
    6. Co-delivery of Anticancer Drug and Adjuvant Agents 
    Luciana B. Lopes, Vanessa C. Dartora, Julia S. Passos et al. 
    7. Hybrid Nanosystems Composed by Lipid and Polymer Materials 
    Maria Mendes, Jessica Silva, João Basso et al. 
    8. Lipid Nanosystems: Targeted Nano-delivery of Therapeutic Agents in Treatment of Cancer 
    Azmat Ali Khan, Mumtaz Jabeen, Iftekhar Hassan et al. 
    9. Monoclonal Antibody Ligands for Liposomes Functionalization: Immunoliposomes Formulation and Clinical Status 
    Sara Zalba, Maria Merino, and Maria J. Garrido 
    10. Active Targeting for Tumor Microenvironment: Integrin Binding Peptides 
    Mohammad Mashreghi and Mahmoud Reza Jaafari 
    11. Targeting Liposomes to Metastatic Tumors with Antibodies Specific for VCAM-1 
    Melvin E. Klegerman 
    12. Active Targeting: Mitochondria-Targeting Signal Peptides 
    Li Li 
    13. Recent Developments of Light: Triggered Liposome Nanosystems for Cancer Treatments 
    Wenjie Chen, Wei Deng, and Ewa M. Goldys 
    14. Ultrasound-Responsive Nanosystems 
    Kartick Chandra Majhi, Shrabani De, and Rashmi Madhuri 
    15. Lipid-Based Nanosystems for Gene and Drug Co-delivery in Cancer Therapy 
    Christian Wölk and Richard D. Harvey 
    16. The Therapeutical Window of Light: Modulating Receptor Proteins and Metabolic Pathways with Light and Its Importance for Disease Control 
    Odete Sofia Lopes Gonçalves, Andreia C. Gomes, and Maria Teresa Neves-Petersen 
    17. Magnetic Lipid-Based Nanosystems for Combined Therapy of Cancer 
    Ana Rita O. Rodrigues, Paulo J. G. Coutinho, and Elisabete M. S. Castanheira 


    Marlene Lúcio, PharmD, PhD in Pharmaceutical Chemistry, is a researcher at the University of Minho, Portugal. She is recepient of the European Young Chemist Award for her outstanding contribution to research in life sciences. Since then, she has been developing lipid-based and hybrid nanosystems for several therapeutic applications.
    Carla M. Lopes, PharmD, PhD in Pharmaceutical Technology, is an assistant professor at Fernando Pessoa University, Portugal. She has done scientific consulting for health companies and has more than 10 years of experience in the development of lipid-based nanocarriers for targeting the delivery of bioactive compounds.
    M. Elisabete C. D. Real Oliveira, PhD in Physics, is an associate professor with habilitation at the Physics Department of the University of Minho. She has over 10 years of experience in the development of liposomal nanosystems for biological applications, namely cancer cell transfection, and siRNA silencing therapy in cancer.