Fundamentals of Asymmetric Synthesis: 1st Edition (Hardback) book cover

Fundamentals of Asymmetric Synthesis

1st Edition

By G. L. David Krupadanam

CRC Press

468 pages

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Hardback: 9781482260618
pub: 2014-08-25
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Description

    Asymmetric synthesis is an integral part of synthetic organic chemistry. Some of the reactions in this book were known prior to 1980, while several new ones, particularly catalytic asymmetric reactions, have been discovered in the recent years. The impact of this new class of reactions has been impressively extensive—both on organic and medicinal chemistry. These reactions have been accepted whole-heartedly by synthetic organic chemists in developing shorter routes for complex natural targets as well as in the manufacture of a wide range of drug intermediates.

Table of Contents

Introduction

Terms, Definitions and Concepts in Asymmetric Synthesis

Achiral and Chiral Molecules and Their Properties

Prochirality

Enantioselective and Diastereoselective Synthesis

Methods for Monitoring Enantioselective and Diastereoselective Synthesis

Methods for Inducing Asymmetry

Chiral Substrate Controlled Asymmetric Reactions: Diastereoselection in acyclic systems

Chiral auxiliary controlled asymmetric reactions—Asymmetric α-alkylations

Chiral Stoichiometric Reagent Controlled Asymmetric Synthesis: Chiral Boron Reagents

Chiral Catalyst Mediated Asymmetric Reactions: Enzymes

Chiral Organometallic Catalysed Asymmetric Reactions: Sharpless Asymmetric Epoxidations, Dihydroxylations and Aminohydroxylations

Chiral Organometallic Catalysed Asymmetric Reactions

Organocatalysts in Asymmetric Synthesis—Chiral Additive Mediated Reactions

Asymmetric Aldol Reaction

Asymmetric Diels–Alder reactions

Stereoselective Synthesis and Stereospecific Synthesis

Index

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI013000
SCIENCE / Chemistry / General
SCI013040
SCIENCE / Chemistry / Organic